Strain budget of the Ecuador–Colombia subduction zone: A stochastic view

The 2016 Pedernales earthquake (M_W=7.8) ruptured a portion of the Colombia–Ecuador subduction interface where several large historical earthquakes have been documented since the great 1906 earthquake (M=8.6). Considering all significant ruptures that occurred in the region, it has been suggested that the cumulative moment generated co-seismically along this part of the subduction over the last century exceeds the moment deficit accumulated inter-seismically since 1906. Such an excess challenges simple models with earthquakes resetting the elastic strain accumulated inter-seismically in locked asperities. These inferences are however associated with large uncertainties that are generally unknown. The impact of spatial smoothing constraints on co-seismic and inter-seismic models also prevents any robust assessment of the strain budget. We propose a Bayesian kinematic slip model of the 2016 Pedernales earthquake using the most comprehensive dataset to date including InSAR and GPS offsets, tsunami waveforms, and kinematic records from high-rate GPS and strong-motions. In addition, we use inter-seismic geodetic velocities to produce a probabilistic inter-seismic coupling model of the subduction interface. Our stochastic co-seismic and inter-seismic solutions include the ensemble of all plausible models consistent with our prior information and that fit the observations within uncertainties. The analysis of these model ensembles indicates that an excess of co-seismic moment during the 1906–2016 period is likely in Central Ecuador only if we assume that 1942 and 2016 earthquakes are colocated. If this assumption is relaxed, we show that this conclusion no longer holds given uncertainties in co- and inter-seismic processes. The comparison of 1942 and 2016 teleseismic records reveals large uncertainties in the location of the 1942 event, hampering our ability to draw strong conclusions on the unbalanced moment budget in the region. Our results also show a heterogeneous coupling of the subduction interface that coincides with two slip asperities in our co-seismic model for the 2016 Pedernales earthquake and with the location of historical ruptures in 1958, 1979 and 1998. The spatial variability in coupling and complexity in earthquake history suggest strong heterogeneities in frictional properties of the subduction megathrust

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis

Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of chronic inflammatory diseases such as psoriasis. Lipopolysaccharide (LPS) or peptidoglycan (PGN) induced tolerance, a phenomenon of transient unresponsiveness of cells to repeated or prolonged stimulation, proved valuable model for the study of chronic inflammation. Thus, the aim of this study was the identification of the transcriptional diversity of primary human immature dendritic cells (iDCs) upon PGN induced tolerance. Using SAGESeq approach, a tag-based transcriptome sequencing method, we investigated gene expression changes of primary human iDCs upon stimulation or restimulation with Staphylococcus aureus derived PGN, a widely used TLR2 ligand. Based on the expression pattern of the altered genes, we identified non-tolerizeable and tolerizeable genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (Kegg) analysis showed marked enrichment of immune-, cell cycle- and apoptosis related genes. In parallel to the marked induction of proinflammatory mediators, negative feedback regulators of innate immunity, such as TNFAIP3, TNFAIP8, Tyro3 and Mer are markedly downregulated in tolerant cells. We also demonstrate, that the expression pattern of TNFAIP3 and TNFAIP8 is altered in both lesional, and non-lesional skin of psoriatic patients. Finally, we show that pretreatment of immature dendritic cells with anti-TNF-α inhibits the expression of IL-6 and CCL1 in tolerant iDCs and partially releases the suppression of TNFAIP8. Our findings suggest that after PGN stimulation/restimulation the host cell utilizes different mechanisms in order to maintain critical balance between inflammation and tolerance. Importantly, the transcriptome sequencing of stimulated/restimulated iDCs identified numerous genes with altered expression to date not associated with role in chronic inflammation, underlying the relevance of our in vitro model for further characterization of IFNprimed iDCs

Lithography-Free Fabrication of Large Area Subwavelength Antireflection Structures Using Thermally Dewetted Pt/Pd Alloy Etch Mask

We have demonstrated lithography-free, simple, and large area fabrication method for subwavelength antireflection structures (SAS) to achieve low reflectance of silicon (Si) surface. Thin film of Pt/Pd alloy on a Si substrate is melted and agglomerated into hemispheric nanodots by thermal dewetting process, and the array of the nanodots is used as etch mask for reactive ion etching (RIE) to form SAS on the Si surface. Two critical parameters, the temperature of thermal dewetting processes and the duration of RIE, have been experimentally studied to achieve very low reflectance from SAS. All the SAS have well-tapered shapes that the refractive index may be changed continuously and monotonously in the direction of incident light. In the wavelength range from 350 to 1800 nm, the measured reflectance of the fabricated SAS averages out to 5%. Especially in the wavelength range from 550 to 650 nm, which falls within visible light, the measured reflectance is under 0.01%

Preliminary study on the utilization of Ca2+ and HCO3 − in karst water by different sources of Chlorella vulgaris

This article aims to present a picture of how a university discipline has been created in Lithuania, given the background of changes caused by the Lithuania’s emancipation from the Soviet Union. The theoretical frame of reference is provided by a modified model of Bronfenbrenners developmental ecology. Data collection has primarily been in the form of interviews with university staff from Lithuanian institutions for higher education. In addition to the interviews, literature lists, course schedules and other key documents have been collected and analysed. The analysis focuses on individual’s conceptualisation of three main areas. The study demonstrates how the creation of management and economics as a university discipline in Lithuania has been formed by a combination of political/ideological, economic, institutional and individual factors. One of the study’s main contributions is to highlight the significance of the concept of academic freedom and to focus on the paradox, where constraint under the old system is replaced by another form of constraint. In this case, where the rigidity of the old Soviet doctrine is replaced by a new freedom; but instead of being given greater opportunities to influence and change the subject, the academic staff are forced into a position where, once again they are subjugated to the influences of international sources

Alcohol Facilitates CD1d Loading, Subsequent Activation of NKT Cells, and Reduces the Incidence of Diabetes in NOD Mice

Background: Ethanol ('alcohol') is a partly hydrophobic detergent that may affect the accessibility of glycolipids thereby influencing immunological effects of these molecules. Methods: The study included cellular in vitro tests using α-galactosylceramide (αGalCer), and in vivo NOD mice experiments detecting diabetes incidence and performing behavioural and bacterial analyses. Results: Alcohol in concentrations from 0.6% to 2.5% increased IL-2 production from NKT cells stimulated with αGalCer by 60% (p<0.05). CD1d expressed on HeLa cells contained significantly increasing amounts of αGalCer with increasing concentrations of alcohol, suggesting that alcohol facilitated the passive loading of αGalCer to CD1d. NOD mice were found to tolerate 5% ethanol in their drinking water without signs of impairment in liver function. Giving this treatment, the diabetes incidence declined significantly. Higher numbers of CD3+CD49b+ NKT cells were found in spleen and liver of the alcohol treated compared to the control mice (p<0.05), whereas the amount of CD4+Foxp3+ regulator T cells did not differ. Increased concentrations of IFN-γ were detected in 24-hour blood samples of alcohol treated mice. Behavioural studies showed no change in attitude of the ethanol-consuming mice, and bacterial composition of caecum samples was not affected by alcohol, disqualifying these as protective mechanisms. Conclusion: Alcohol facilitates the uptake of glycolipids and the stimulation of NKT cells, which are known to counteract Type 1 diabetes development. We propose that this is the acting mechanism by which treatment with alcohol reduces the incidence of diabetes in NOD mice. This is corroborated by epidemiology showing beneficial effect of alcohol to reduce the severity of atherosclerosis and related diseases

Revisiting the 1992 Landers earthquake: a Bayesian exploration of co-seismic slip and off-fault damage

International audienc

Volatilization of alpha activity during heating of radioactive ashes

Thermal treatment of mixed wastes is one option that has the potential to significantly reduce final disposal volume and increase the durability of the waste form in one operation. One potential concern in evaluation and design of such a system, however, is the volatilization of contaminants of concern, which may increase secondary waste generation, cause permitting concerns, and complicate design of engineering containment. To evaluate the potential for significant contaminant losses, ash from mixed waste incineration was stabilized by melting at 1300{degrees}C while offgases and evolved particulate were captured for analysis. Losses of gamma emitting radionuclides were up to 20% and dominated by cesium, but losses of plutonium and uranium were less then 0.1%