Effect of Lactobacillus casei on the production of pro-inflammatory markers in streptozotocin-induced diabetic rats.

It has been demonstrated that probiotic supplementation has positive effects in several murine models of disease through influences on host immune responses. This study examined the effect of Lactobacillus casei strain Shirota (L. casei Shirota) on the blood glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-4 (IL-4), and body weight among STZ-induced diabetic rats. Diabetes mellitus was induced by streptozotocin (STZ, 50 mg/kg BW) in male Sprague–Dawley rats. Streptozotocin caused a significant increase in the blood glucose levels, CRP, and IL-6. L. casei Shirota supplementation lowered the CRP and IL-6 levels but had no significant effect on the blood glucose levels, body weight, or IL-4. Inflammation was determined histologically. The presence of the innate immune cells was not detectable in the liver of L. casei Shirota-treated hyperglycemic rats. The probiotic L. casei Shirota significantly lowered blood levels of pro-inflammatory cytokines (IL-6, CRP) and neutrophils in diabetic rats, showing a lower risk of diabetes mellitus and its complications

Rosacea

Rosacea is an inflammatory, chronic-recurring dermatitis of the face. It is common in adult females with I\u2013II phototype. It is characterized clinically by the presence of one or more of the following features: flushing, erythema, telangiectasia, papules, pustules, and nodules. Ocular involvement can also occur. Etiopathogenetic role of Demodex folliculorum and Helicobacter pylori has not been confirmed. The National Rosacea Society Expert Committee divided the disease into four clinical varieties (rosacea characterized by flushing and erythema, with or without telangiectasia, papulopustular rosacea, phymatous rosacea, and ocular rosacea). According to Cochrane, topical metronidazole and azelaic acid as well as oral tetracyclines and metronidazole are effective in the treatment of rosacea. Literature data about the use of peelings are very poor. In some patients, salicylic acid, azelaic acid, and mandelic acid were used