Die Gesellschaft der frühen „Dunklen Jahrhunderte“ auf Kreta. Eine Untersuchung der archäologischen Hinterlassenschaften der Bevölkerung Kretas während der Spätminoisch IIIC und Subminoischen Zeit im Bezug auf ihre soziale Aussagekraft und Bedeutung (Daidalos 2)

Im Rahmen der hier vorgelegten Arbeit „Die Gesellschaft der frühen ‚Dunklen Jahrhunderte’ auf Kreta“ soll der Versuch unternommen werden, ein Bild der gesellschaftlichen Strukturen auf Kreta zu dieser Zeit zu erstellen. Dabei steht die Untersuchung der archäologischen Quellen und Hinterlassenschaften der kretischen Bevölkerung im Mittelpunkt, um Fragen nach der Stratifizierung der Gesellschaft nachzugehen und die politische Situation auf der Insel zu klären. Auch werden Aspekte der Wirtschaft und des Handels, sowie der Religion und des Kultes als Bestandteile des alltäglichen Lebens betrachtet, soweit sie archäologisch fassbar sind. Die chronologische Spanne der bearbeiteten Epoche umfasst die Phase Spätminoisch IIIC und die Subminoische Zeit, also den Abschnitt der kretischen Prähistorie nach dem endgültigen Zusammenbruch der mykenischen Palastkultur um 1200 v. Chr., die nach der Zerstörung der minoischen Paläste um 1490 v. Chr, auch die Kontrolle über die Insel Kreta innehatte. Die Ergebnisse dieser Untersuchungen spiegeln gleichermaßen ein Bild von Kontinuität und Wandel wider, welches alle Bereiche des täglichen Lebens betrifft. Der Hauptteil der Arbeit enthält einen umfassenden Katalog aller chronologisch relevanten Fundorte der Insel und die Auswertung der archäologischen Quellen in Bezug zu ihrer sozio-politischen Aussagekraft und Bedeutung während einer noch immer spärlich untersuchten Epoche der kretischen Frühgeschichte

Comment on “Potential short‐term earthquake forecasting by farm animal monitoring” by Wikelski, Mueller, Scocco, Catorci, Desinov, Belyaev, Keim, Pohlmeier, Fechteler, and Mai

Based on an analysis of continuous monitoring of farm animal behavior in the region of the 2016 M6.6 Norcia earthquake in Italy, Wikelski et al., 2020; (Seismol Res Lett, 89, 2020, 1238) conclude that animal activity can be anticipated with subsequent seismic activity and that this finding might help to design a "short-term earthquake forecasting method." We show that this result is based on an incomplete analysis and misleading interpretations. Applying state-of-the-art methods of statistics, we demonstrate that the proposed anticipatory patterns cannot be distinguished from random patterns, and consequently, the observed anomalies in animal activity do not have any forecasting power

Kontextbasierte Eventerkennung in der Logistik mit drahtloser Sensornetztechnologie

Eine lückenlose Echtzeitüberwachung von Logistikprozessen erlaubt es Events frühzeitig zu erkennen und auf diese angemessen zu reagieren und eröffnet das Potential Haftungsfragen leichter zu klären und Versicherungsprämien zu senken. Mittels drahtloser Sensornetz-technologie wird eine entsprechende Echtzeiterkennung von und -benachrichtigung über Events in Logistikprozessen möglich. Diese muss aber sowohl kosten- und energieeffizient als auch kundenorientiert realisiert werden. Im vorliegenden Beitrag wird hierzu das Konzept der „übertragungsrelevanten Events“ vorgestellt und zur konkreten Umsetzung ein Scoresheet-basiertes Verfahren entwickelt. Die Effizienz und Vorteilhaftigkeit dieses Verfahrens im Vergleich zu anderen Verfahren zur Eventerkennung und -benachrichtigung im Rahmen einer Echtzeitüberwachung von Logistikprozessen wird mittels Simulations-experimenten gezeigt

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

SummaryThe Roquin-1 protein binds to messenger RNAs (mRNAs) and regulates gene expression posttranscriptionally. A single point mutation in Roquin-1, but not gene ablation, increases follicular helper T (Tfh) cell numbers and causes lupus-like autoimmune disease in mice. In T cells, we did not identify a unique role for the much lower expressed paralog Roquin-2. However, combined ablation of both genes induced accumulation of T cells with an effector and follicular helper phenotype. We showed that Roquin-1 and Roquin-2 proteins redundantly repressed the mRNA of inducible costimulator (Icos) and identified the Ox40 costimulatory receptor as another shared mRNA target. Combined acute deletion increased Ox40 signaling, as well as Irf4 expression, and imposed Tfh differentiation on CD4+ T cells. These data imply that both proteins maintain tolerance by preventing inappropriate T cell activation and Tfh cell differentiation, and that Roquin-2 compensates in the absence of Roquin-1, but not in the presence of its mutated form

Evaluation of Concomitant Systemic Treatment in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Radiotherapy

IMPORTANCE The number of older adults with head and neck squamous cell carcinoma (HNSCC) is increasing, and these patients are underrepresented in clinical trials. It is unclear whether the addition of chemotherapy or cetuximab to radiotherapy is associated with improved survival in older adults with HNSCC. OBJECTIVE To examine whether the addition of chemotherapy or cetuximab to definitive radiotherapy is associated with improved survival in patients with locoregionally advanced (LA) HNSCC. DESIGN, SETTING, AND PARTICIPANTS The Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy (SENIOR) study is an international, multicenter cohort study including older adults (≥65 years) with LA-HNSCCs of the oral cavity, oropharynx/hypopharynx, or larynx treated with definitive radiotherapy, either alone or with concomitant systemic treatment, between January 2005 and December 2019 at 12 academic centers in the US and Europe. Data analysis was conducted from June 4 to August 10, 2022. INTERVENTIONS All patients underwent definitive radiotherapy alone or with concomitant systemic treatment. MAIN OUTCOMES AND MEASURES The primary outcome was overall survival. Secondary outcomes included progression-free survival and locoregional failure rate. RESULTS Among the 1044 patients (734 men [70.3%]; median [IQR] age, 73 [69-78] years) included in this study, 234 patients (22.4%) were treated with radiotherapy alone and 810 patients (77.6%) received concomitant systemic treatment with chemotherapy (677 [64.8%]) or cetuximab (133 [12.7%]). Using inverse probability weighting to attribute for selection bias, chemoradiation was associated with longer overall survival than radiotherapy alone (hazard ratio [HR], 0.61; 95% CI, 0.48-0.77; P < .001), whereas cetuximab-based bioradiotherapy was not (HR, 0.94; 95% CI, 0.70-1.27; P = .70). Progression-free survival was also longer after the addition of chemotherapy (HR, 0.65; 95% CI, 0.52-0.81; P < .001), while the locoregional failure rate was not significantly different (subhazard ratio, 0.62; 95% CI, 0.30-1.26; P = .19). The survival benefit of the chemoradiation group was present in patients up to age 80 years (65-69 years: HR, 0.52; 95% CI, 0.33-0.82; 70-79 years: HR, 0.60; 95% CI, 0.43-0.85), but was absent in patients aged 80 years or older (HR, 0.89; 95% CI, 0.56-1.41). CONCLUSIONS AND RELEVANCE In this cohort study of older adults with LA- HNSCC, chemoradiation, but not cetuximab-based bioradiotherapy, was associated with longer survival compared with radiotherapy alone

A Multicenter Evaluation of Different Chemotherapy Regimens in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiation

PURPOSE: The number of older adults with head-and-neck squamous cell carcinoma (HNSCC) is increasing, and treatment of these patients is challenging. Although cisplatin-based chemotherapy concomitantly with radiotherapy is considered standard regimen for patients with locoregionally advanced HNSCC, there is substantial real-world heterogeneity regarding concomitant chemotherapy in older HNSCC patients. METHODS: The XXX study is an international multicenter cohort study including older (≥65 years) HNSCC patients treated with definitive radiotherapy at 13 academic centers in the United States and Europe. Here, patients with concomitant chemoradiation were analyzed regarding overall survival (OS) and progression-free survival (PFS) using Kaplan-Meier analyses, while Fine-Gray competing risks regressions were performed regarding the incidence of locoregional failures (LRFs) and distant metastases (DMs). RESULTS: Six hundred ninety-seven patients with a median age of 71 years were included in this analysis. Single-agent cisplatin was the most common chemotherapy regimen (n=310; 44%), followed by cisplatin plus 5-fluorouracil (n=137; 20%), carboplatin (n=73; 10%), and mitomycin c plus 5-fluorouracil (n=64; 9%). Carboplatin-based regimens were associated with diminished PFS (HR=1.39 [1.03-1.89], p.05). Median cumulative dose of cisplatin was 180 mg/m2 (IQR, 120-200 mg/m2). Cumulative cisplatin doses ≥200 mg/m2 were associated with increased OS (HR=0.71 [0.53-0.95], p=.02), PFS (HR=0.66 [0.51-0.87], p=.003), and lower incidence of LRFs (SHR=0.50 [0.31-0.80], p=.004). Higher cumulative cisplatin doses remained an independent prognostic variable in the multivariate regression analysis for OS (HR=0.996 [0.993-0.999], p=.009). CONCLUSIONS: Single-agent cisplatin can be considered as the standard chemotherapy regimen for older HNSCC patients who can tolerate cisplatin. Cumulative cisplatin doses are prognostically relevant also in older HNSCC patients