On the Limitations of Computational Fuzzy Extractors

We present a negative result of fuzzy extractors with computational security. Specifically, we show that, under a certain computational condition, the existence of a computational fuzzy extractor implies the existence of an information-theoretic fuzzy extractor with slightly weaker parameters. The condition is that the generation procedure of the fuzzy extractor is efficiently invertible by an injective function. Our result implies that to circumvent the limitations of information-theoretic fuzzy extractors, we need to employ computational fuzzy extractors that are not invertible by injective functions

Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion

Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion.BackgroundMidkine, a heparin-binding growth factor, is involved in the migration of inflammatory cells. The inflammatory cell migration to the tubulointerstitium of the kidney after ischemia/reperfusion (I/R) injury is attenuated in midkine gene–deficient mice, resulting in better preservation of the tubulointerstitium compared with wild-type mice. In the present investigation, we planned to evaluate the usefulness of antisense midkine for the therapy of ischemic renal failure.MethodsMidkine antisense phosphorothioate oligodeoxyribonucleotide (ODN) at a dose of 1 mg/kg in saline was intravenously administered to mice 1 day before or after I/R. The kidneys were removed for examination 1, 2, 3, and 7 days after I/R.ResultsIt was rapidly incorporated into proximal tubular epithelial cells, and inhibited midkine synthesis, leading to reduced migration of inflammatory cells to the injured epithelial layer. Consequently, the midkine antisense ODN-treated animals exhibited less severe renal damage than untreated or midkine sense ODN-treated animals 2 days after I/R as assessed by morphologic criteria and blood urea nitrogen (BUN) and serum creatinine levels. Midkine expression, BUN, and serum creatinine levels were not significantly different between injection of midkine antisense ODN before and after ischemic injury.ConclusionThese results indicate that intravenous injection of midkine antisense ODN is a candidate for a novel therapeutic strategy against acute tubulointerstitial injury induced by I/R injury

The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects.ArticleJOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)journal articl

Present status of organ transplantation from DCD donors in Japan

As organ donation under DBD donors has reached a plateau in developed transplantation countries in Europe and the United States, organ donation after DCD donors has been actively promoted. This has led to the introduction of extracorporeal membrane oxygenation (ECMO) after cardiac arrest and withdrawal from life support when the patient is incapable of recovery, enabling the removal and transplantation of multiple organs after cardiac arrest. In Japan, these efforts have not been implemented, and only kidneys have been transplanted from DCD donors after spontaneous cardiac arrest. In addition, the revision of the Organ Transplant Law to allow organ donation under brain death with only family approval has drastically reduced the number of DCD donors. In Japan, efforts are underway to introduce ECMO and to wean patients off life support systems so that multi-organ donation after cardiac arrest will be possible as in Europe and the United States

Repeated Games for Generating Randomness in Encryption

In encryption schemes, the sender may not generate randomness properly if generating randomness is costly, and the sender is not concerned about the security of a message. The problem was studied by the first author (2016), and was formalized in a game-theoretic framework. In this work, we construct an encryption scheme with an optimal round complexity on the basis of the mechanism of repeated games

CD140b and CD73 are markers for human induced pluripotent stem cell‐derived erythropoietin‐producing cells

Renal anemia in chronic kidney disease is treated with recombinant human erythropoietin (rhEPO). However, some patients with anemia do not respond well to rhEPO, emphasizing the need for a more biocompatible EPO. Differentiation protocols for hepatic lineages have been modified to enable production from human induced pluripotent stem cell (hiPSC)‐derived EPO‐producing cells (EPO cells). However, markers for hiPSC‐EPO cells are lacking, making it difficult to purify hiPSC‐EPO cells and therefore to optimize EPO production and cell counts for transplantation. To address these issues, we investigated whether CD140b and CD73 could be used as markers for hiPSC‐EPO cells. We measured the expression of EPO, CD140b, and CD73 in hiPSC‐EPO cells and the EPO concentration in the cell supernatant by immunohistochemistry and enzyme‐linked immunosorbent assays on culture day 13, revealing that expression levels of CD140b and CD73 are correlated with the level of EPO. In addition, rates of CD140b+ CD73+ cells were observed to be correlated with the concentration of EPO. Thus, our results suggest that CD140b and CD73 may be markers for hiPSC‐EPO cells