A Raman Lidar with a Deep Ultraviolet Laser for Continuous Water Vapor Profiling in the Atmospheric Boundary Layer

A Raman lidar with a deep ultraviolet laser was constructed to continuously monitor water vapor distributions in the atmospheric boundary layer for twenty-four hours. We employ a laser at a wavelength of 266 nm and detects the light separated into an elastic backscatter signal and vibrational Raman signals of oxygen, nitrogen, and water vapor. The lidar was encased in a temperature-controlled and vibration-isolated compact container, resistant to a variety of environmental conditions. Water vapor profile observations were made for twelve months from November 24, 2017, to November 29, 2018. These observations were compared with collocated radiosonde measurements for daytime and nighttime conditions

Effect of Lubrication and Forging Load on Surface Roughness, Residual Stress, and Deformation of Cold Forging Tools

Cold forging is a metal forming that which uses localized compressive force at room temperature. During the cold forging process, the tool is subjected to extremely high loads and abrasive wear. Lubrication plays an important role in cold forging to improve product quality and tool life by preventing direct metallic contact. Surface roughness and residual stress also greatly affects the service life of a tool. In this study, variations in surface roughness, residual stress, and specimen deformation with the number of cold forging cycles were investigated under different forging conditions. Specimens that were made of heat-treated SKH51 (59-61 HRC), a high-speed tool steel with a polished working surface, were used. The specimens were subjected to an upsetting process. Compressive residual stress, surface roughness, and specimen deformation showed a positive relationship with the number of forging cycles up to a certain limit and became almost constant in most of the forging conditions. A larger change in residual stress and surface roughness was observed at the center of the specimens in all the forging conditions. The effect of the magnitude of the forging load on the above discussed parameters is large when compared to the effect of the lubrication conditions

Lck inhibition attenuate lung fibrosis by suppressing Treg activity

Background Lymphocyte-specific protein tyrosine kinase (Lck) is a member of the Src family of tyrosine kinases. The significance of Lck inhibition in lung fibrosis has not yet been fully elucidated, even though lung fibrosis is commonly preceded by inflammation caused by infiltration of Tcells expressing Lck. In this study, we examined the effect of Lck inhibition in an experimental mouse model of lung fibrosis. We also evaluated the effect of Lck inhibition on the expression of TGF-β1, an inhibitory cytokine regulating the immune function, in regulatory T-cells (Tregs). Methods Lung fibrosis was induced in mice by intratracheal administration of bleomycin. A-770041, a Lck-specific inhibitor, was administrated daily by gavage. Tregs were isolated from the lung using a CD4+CD25+ Regulatory T-cell Isolation Kit. The expression of Tgfb on Tregs was examined by flow cytometry and quantitative polymerase chain reaction. The concentration of TGF-β in bronchoalveolar lavage fluid (BALF) and cell culture supernatant from Tregs was quantified by an enzyme-linked immunosorbent assay. Results A-770041 inhibited the phosphorylation of Lck in murine lymphocytes to the same degree as nintedanib. A-770041 attenuated lung fibrosis in bleomycin-treated mice and reduced the concentration of TGF-β in BALF. A flow-cytometry analysis showed that A-770041 reduced the number of Tregs producing TGF-β1 in the lung. In isolated Tregs, Lck inhibition by A-770041 decreased the Tgfb mRNA level as well as the concentration of TGF-β in the supernatant. Conclusions These results suggest that Lck inhibition attenuated lung fibrosis by suppressing TGF-β production in Tregs and support the role of Tregs in the pathogenesis of lung fibrosis

Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis

Background The widespread administration of the Haemophilus influenzae type b vaccine has led to the predominance of non-typable H. influenzae (NTHi). However, the occurrence of invasive NTHi infection based on gynecologic diseases is still rare. Case presentation A 51-year-old Japanese woman with a history of adenomyoma presented with fever. Blood cultures and a vaginal discharge culture were positive with NTHi. With the high uptake in the uterus with 67Ga scintigraphy, she was diagnosed with invasive NTHi infection. In addition to antibiotic administrations, a total hysterectomy was performed. The pathological analysis found microabscess formations in adenomyosis. Conclusions Although NTHi bacteremia consequent to a microabscess in adenomyosis is rare, this case emphasizes the need to consider the uterus as a potential source of infection in patients with underlying gynecological diseases, including an invasive NTHi infection with no known primary focus.

A case of interstitial pneumonia associated with anti-PL-7 antibody in a patient with rheumatoid arthritis

A 65-year-old female had been treated rheumatoid arthritis (RA), interstitial pneumonia (IP) and nephrotic syndrome with prednisolone and cyclosporine. She was emergently admitted to our hospital due to the worsening exertional dyspnea and severe hypoxemia. Chest computed tomography (CT) showed new diffuse ground-glass opacities (GGOs) with slight consolidations along with bronchovascular bundle were observed in addition to pre-existing reticular shadows in both lungs with lower lobe-predominance. An acute exacerbation (AE) of pre-existing IP triggered by an infection was suspected, and the treatment with antibiotics and corticosteroid pulse therapy improved her general condition and chest radiological findings. Because some auto-antibodies associated with acute/subacute onset IP have recently become available in clinic, we examined those including anti-aminoacyl tRNA synthetase (ARS) antibodies, and found that she was positive for anti-PL-7 antibody. We diagnosed her anti-synthetase syndrome (ASS) without symptom of myositis, and her IP was considered to be ASS-related. The careful consideration is necessary to precisely diagnose and treat the patients with RA-associated interstitial lung diseases as the several etiologies may be overlapped in the same patient

Recent Progress in Development of Carbon-Nanotube-Based Photo-Thermoelectric Sensors and Their Applications in Ubiquitous Non-Destructive Inspections

The photo-thermoelectric (PTE) effect in electronic materials effectively combines photo-absorption-induced local heating and associated thermoelectric conversion for uncooled and broadband photo-detection. In particular, this work comprehensively summarizes the operating mechanism of carbon nanotube (CNT)-film-based PTE sensors and ubiquitous non-destructive inspections realized by exploiting the material properties of CNT films. Formation of heterogeneous material junctions across the CNT-film-based PTE sensors, namely photo-detection interfaces, triggers the Seebeck effect with photo-absorption-induced local heating. Typical photo-detection interfaces include a channel–electrode boundary and a junction between P-type CNTs and N-type CNTs (PN junctions). While the original CNT film channel exhibits positive Seebeck coefficient values, the material selections of the counterpart freely govern the intensity and polarity of the PTE response signals. Based on these operating mechanisms, CNT film PTE sensors demonstrate a variety of physical and chemical non-destructive inspections. The device aggregates broad multi-spectral optical information regarding the targets and reconstructs their inner composite or layered structures. Arbitrary deformations of the device are attributed to the macroscopic flexibility of the CNT films to further monitor targets from omni-directional viewing angles without blind spots. Detection of blackbody radiation from targets using the device also visualizes their behaviors and associated changes

Surface integrity of machined surface in simultaneous cutting of CFRP

Carbon fiber-reinforced plastic (CFRP), a carbon fiber composite material, has high specific strength and stiffness, and has attracted attention as a structural material for transport machines from the viewpoint of improving fuel efficiency through weight reduction. However, the exiting CFRP processing methods have several disadvantages such as high cost, tool wear due to formation of hard chips during cutting, and occurrence of delamination that degrades machining accuracy. These limitations impede the practical application of CFRP. The purpose of this study is to propose a low cost and high precision drilling method “simultaneous cutting” by stacking the different materials with CFRP. Until now, high precision hole drilling has been studied by stacking titanium on CFRP. Because CFRP and titanium parts are joined by bolts in aircraft and so on. However, in this study, an inexpensive and easy to obtain acrylic resin plate was selected as a stacking material to focus on CFRP hole drilling. On the other hand, acrylic resin plate was used for CFRP hole drilling as a waste material. As a result, it was found that the thrust force was reduced by drilling the hole with stacking CFRP between two acrylic resin plates. Furthermore, the occurrence of delamination was suppressed at both the entry and exit sides of the hole

A Raman Lidar with a Deep Ultraviolet Laser for Continuous Water Vapor Profiling in the Atmospheric Boundary Layer

A Raman lidar with a deep ultraviolet laser was constructed to continuously monitor water vapor distributions in the atmospheric boundary layer for twenty-four hours. We employ a laser at a wavelength of 266 nm and detects the light separated into an elastic backscatter signal and vibrational Raman signals of oxygen, nitrogen, and water vapor. The lidar was encased in a temperature-controlled and vibration-isolated compact container, resistant to a variety of environmental conditions. Water vapor profile observations were made for twelve months from November 24, 2017, to November 29, 2018. These observations were compared with collocated radiosonde measurements for daytime and nighttime conditions