Is biomass burning always a dominant contributor of fine aerosols in upper northern Thailand?

Biomass burning (BB) is an important contributor to the air pollution in Southeast Asia (SEA), but the emission sources remain great uncertainty. In this study, PM2.5 samples were collected from an urban (Chiang Mai University, CMU) and a rural (Nong Tao village, NT) site in Chiang Mai, Thailand from February to April (high BB season, HBB) and from June to September (low BB season, LBB) in 2018. Source apportionment of carbonaceous aerosols was carried out by Latin Hypercube Sampling (LHS) method incorporating the radiocarbon (14C) and organic markers (e.g., dehydrated sugars, aromatic acids, etc.). Thereby, carbonaceous aerosols were divided into the fossil-derived elemental carbon (ECf), BB-derived EC (ECbb), fossil-derived primary and secondary organic carbon (POCf, SOCf), BB-derived OC (OCbb) and the remaining OC (OCnf, other). The fractions of ECbb generally prevailed over ECf throughout the year. OCbb was the dominant contributor to total carbon with a clear seasonal trend (65.5 ± 5.8 % at CMU and 79.9 ± 7.6 % at NT in HBB, and 39.1 ± 7.9 % and 42.8 ± 4.6 % in LBB). The distribution of POCf showed a spatial difference with a higher contribution at CMU, while SOCf displayed a temporal variation with a greater fraction in LBB. OCnf, other was originated from biogenic secondary aerosols, cooking emissions and bioaerosols as resolved by the principal component analysis with multiple liner regression model. The OCnf, other contributed within a narrow range of 6.6 %-14.4 %, despite 34.9 ± 7.9 % at NT in LBB. Our results highlight the dominance of BB-derived fractions in carbonaceous aerosols in HBB, and call the attention to the higher production of SOC in LBB

Research progress of natural silk fibroin and the application for drug delivery in chemotherapies

Silk fibroin has been widely used in biological fields due to its biocompatibility, mechanical properties, biodegradability, and safety. Recently, silk fibroin as a drug carrier was developed rapidly and achieved remarkable progress in cancer treatment. The silk fibroin-based delivery system could effectively kill tumor cells without significant side effects and drug resistance. However, few studies have been reported on silk fibroin delivery systems for antitumor therapy. The advancement of silk fibroin-based drug delivery systems research and its applications in cancer therapy are highlighted in this study. The properties, applications, private opinions, and future prospects of silk fibroin carriers are discussed to understand better the development of anti-cancer drug delivery systems, which may also contribute to advancing silk fibroin innovation

Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum

Metarhizium spp. are being used as environmentally friendly alternatives to chemical insecticides, as model systems for studying insect-fungus interactions, and as a resource of genes for biotechnology. We present a comparative analysis of the genome sequences of the broad-spectrum insect pathogen Metarhizium anisopliae and the acridid-specific M. acridum. Whole-genome analyses indicate that the genome structures of these two species are highly syntenic and suggest that the genus Metarhizium evolved from plant endophytes or pathogens. Both M. anisopliae and M. acridum have a strikingly larger proportion of genes encoding secreted proteins than other fungi, while ∼30% of these have no functionally characterized homologs, suggesting hitherto unsuspected interactions between fungal pathogens and insects. The analysis of transposase genes provided evidence of repeat-induced point mutations occurring in M. acridum but not in M. anisopliae. With the help of pathogen-host interaction gene database, ∼16% of Metarhizium genes were identified that are similar to experimentally verified genes involved in pathogenicity in other fungi, particularly plant pathogens. However, relative to M. acridum, M. anisopliae has evolved with many expanded gene families of proteases, chitinases, cytochrome P450s, polyketide synthases, and nonribosomal peptide synthetases for cuticle-degradation, detoxification, and toxin biosynthesis that may facilitate its ability to adapt to heterogenous environments. Transcriptional analysis of both fungi during early infection processes provided further insights into the genes and pathways involved in infectivity and specificity. Of particular note, M. acridum transcribed distinct G-protein coupled receptors on cuticles from locusts (the natural hosts) and cockroaches, whereas M. anisopliae transcribed the same receptor on both hosts. This study will facilitate the identification of virulence genes and the development of improved biocontrol strains with customized properties

Patient-provider relationships in China: A qualitative study on the perspectives of healthcare students and junior professionals.

BackgroundMistrust and conflicts in patient-provider relationships (PPR) have become prevalent in China. The frequency of verbal and physical violence against healthcare workers has been increasing, but few interventions seem to be effective. Limited prior research has focused on the perspectives of healthcare professionals in training. This paper aimed to understand their viewpoints and conceptualize potentially actionable areas for future policy interventions.MethodsWe analyzed de-identified training registration data of a convenience sample of 151 healthcare students and 38 junior professionals from 20 provinces in China. One open-ended question in the registration form asked the participant to comment on PPRs in China. We used qualitative thematic coding to analyze the narrative data. All answers were categorized into three overarching frames: patients, providers, and external agencies/regulations. Frequently mentioned themes in each frame were evaluated to generate an overall theoretical framework.FindingsAlthough fewer than 25% indicated that current PPRs are "good" or acceptable, 98% of respondents were optimistic about the future improvement of these relationships. The leading factors of PPRs mentioned as patient-relevant were eroding trust in the physician, unrealistic expectations, and ineffective communication. The provider-relevant themes highlighted were poor service quality, ineffective communication, and heavy workload. Leading themes relevant to external agencies or regulations were dysfunctional administration system, negative media reports, and disparity in healthcare resource distribution.InterpretationHealthcare professionals in training had a negative view of the current situation but had confidence in future improvement. Patient, provider, and societal factors all contributed to the tension between patients and providers. All aspects of the healthcare sector should be carefully considered when contemplating policy or social interventions to improve the patient-provider relationship

Between Empowerment and Gentrification: A Case Study of Community-Based Tourist Program in Suichang County, China

The phenomenon of hollow villages is a long-lasting obstacle to China’s rural development. With this background, this study examines a for-profit community-based tourist program operated at a rural hollow village in Zhejiang, China and explores how this program facilitates meaningful transformations in the community. The theoretical concept of empowerment was introduced to critically understand and analyse the community transformations, and the data was collected through program-related or village-related media content, participant observation, and focus group interviews. Our findings reveal that varied types of empowerment had been gained by the residents via the program, which has strongly demonstrated the positive and meaningful transformations in the community. Lastly, gentrification, a type of community transformation, was a positive change from the program managerial staff’s view, but it could lead to uncertainties and problems of the economic and political disempowerment to the residents in the long term

Study oncharacteristics of Leaf epidermis of 10 species of Ferns

The leaf epidermal structures of 10 species of ferns (5 genera;3 families) were investigated under light microscope (LM).The results indicated that:(1) Epidermis cells of ferns are mostly irregular,with deep smuate anticlinal walls;(2) The stomatal apparatuses occur in the lower epidermis and most of them are elliptical.In total 9 types of stomatal apparatus are observed in present investigation (Aisocytic type,Polocytic type,Axillocytic type,Anomoteracytic type,Actinocytic type,Copolocytic type,Diacytic type,Desmocytic type,Roundcytic type).Each species possesses 2~6 different types of stomatal apparatus;(3) According to the characters of leaf epidermis,we support that Hypolepidaceae and Dennstaedtiaceae should be combined as one family,but Pteridaceae and Adiantaceae should be separated.The results provide evidences for phylogeny and classification of Hypolepidaceae,Pteridaceae,Adiantaceae

Topological quantum transitions in a two-band Chern insulator with n = 2

Based on a two-band Chern insulator with Chern number n = 2, we study the transport properties and the topological phase transition induced by either an external magnetic field or disorder. In this paper, a characteristic topological phase transition from n = 2 to n = 0, which is in sharp contrast to the plateau-plateau transition in the integer quantum Hall effect, is observed. This unique feature of the phase transition should be ascribed to the minimal two-band feature of this high Chern insulator. We prove this result by studying the transport properties of many different geometrical structures and the evolution of the Chern number in the presence of magnetic fields and strong disorder.Physics, Condensed MatterSCI(E)[email protected]