Psychopathology and 5-hydroxyindoleacetic acid excretion

Schizophrenics and nonschizophrenics do not differ in urinary excretion of 5-hydroxyindoleacetic acid on either a concentration or 24 h basis, nor do they differ in variability of excretion. Although a pattern was observed of decreasing psychopathology with increasing 5-hydroxyindoleacetic acid excretion, this pattern may be related to alterations in physical state accompanying psychopathology rather than to psychopathology per se.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31990/1/0000032.pd

Chromatographic study of "Reigelhaupt" chromogens in urine

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32280/1/0000342.pd

Plasma catecholamines and social behavior in male vervet monkeys (Cercopithecus aethiops sabaeus)

Many investigations in humans indicate that epinephrine, norepinephrine and their ratio may correlate with such traits as social competence, academic achievement, and aggression. However, the socioeconomic, dietary, and environmental confounds accompanying most human studies complicate their interpretation. Social status, aggression, and other social behaviors can be reliably assessed in nonhuman primates under conditions controlling for crucial environmental factors. If interpretation of human studies is correct, dominant and subordinate male vervet monkeys should exhibit distinctive patterns of catecholamine secretion. To test this possibility, seventeen adult male monkeys living in six stable social groups were observed for 6 months. Based on their success in agonistic events, subjects were categorized as dominant or subordinate. Alpha scores were calculated from empirically derived factors to provide a noncategorical measure of dominant behavioral style. Plasma epinephrine and norepinephrine samples obtained from anesthetized subjects did not differ between dominant and subordinate males. Alpha scores, however, distinguished high from low norepinephrine/epinephrine ratio groups. These findings are consistent with studies in humans linking high epinephrine, low norepinephrine, and social competence.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30093/1/0000465.pd