腰部脊柱管狭窄症における肥厚した黄色靭帯の病態解析

Tohoku University井樋栄二課

Efficacy and Safety of Endoscopic Ultrasound-guided Ethanol Ablation Therapy for Pancreatic Neuroendocrine Tumors

Recently, endoscopic ultrasonography (EUS)-guided ethanol ablation for small pancreatic neuroendocrine tumors (p-NETs) has been reported. However, the efficacy and safety of the technique remain unclear. We have launched a prospective pilot study of EUS-guided ethanol ablation for p-NETs. The major eligibility criteria are the presence of a pathologically diagnosed grade (G) 1 or G2 p-NET, a tumor size of 2cm, and being a poor candidate for surgery. A total of 5 patients will be treated. The primary endpoint will be the complete ablation rate at 1 month after treatment

EMPRESS. II. Highly Fe-Enriched Metal-poor Galaxies with ∼1.0\sim 1.0 (Fe/O)⊙_\odot and 0.020.02 (O/H)⊙_\odot : Possible Traces of Super Massive (>300M⊙>300 M_{\odot}) Stars in Early Galaxies

We present element abundance ratios and ionizing radiation of local young low-mass (~$10^{6}$ M_sun) extremely metal poor galaxies (EMPGs) with a 2% solar oxygen abundance (O/H)_sun and a high specific star-formation rate (sSFR~300 Gyr$^{-1}$), and other (extremely) metal poor galaxies, which are compiled from Extremely Metal-Poor Representatives Explored by the Subaru Survey (EMPRESS) and the literature. Weak emission lines such as [FeIII]4658 and HeII4686 are detected in very deep optical spectra of the EMPGs taken with 8m-class telescopes including Keck and Subaru (Kojima et al. 2019, Izotov et al. 2018), enabling us to derive element abundance ratios with photoionization models. We find that neon- and argon-to-oxygen ratios are comparable to those of known local dwarf galaxies, and that the nitrogen-to-oxygen abundance ratios (N/O) are lower than 20% (N/O)_sun consistent with the low oxygen abundance. However, the iron-to-oxygen abundance ratios (Fe/O) of the EMPGs are generally high; the EMPGs with the 2%-solar oxygen abundance show high Fe/O ratios of ~90-140% (Fe/O)_sun, which are unlikely explained by suggested scenarios of Type Ia supernova iron productions, iron's dust depletion, and metal-poor gas inflow onto previously metal-riched galaxies with solar abundances. Moreover, these EMPGs have very high HeII4686/H$\beta$ ratios of ~1/40, which are not reproduced by existing models of high-mass X-ray binaries whose progenitor stellar masses are less than 120 M_sun. Comparing stellar-nucleosynthesis and photoionization models with a comprehensive sample of EMPGs identified by this and previous EMPG studies, we propose that both the high Fe/O ratios and the high HeII4686/H$\beta$ ratios are explained by the past existence of super massive ($>$300 M_sun) stars, which may evolve into intermediate-mass black holes ($\gtrsim$100 M_sun).Comment: ApJ in press. 23 pages, 7 Figures, 6 Table

Extremely Metal-Poor Representatives Explored by the Subaru Survey (EMPRESS). I. A Successful Machine Learning Selection of Metal-Poor Galaxies and the Discovery of a Galaxy with M*<10^6 M_sun and 0.016 Z_sun

We have initiated a new survey for local extremely metal-poor galaxies (EMPGs) with Subaru/Hyper Suprime-Cam (HSC) large-area (~500 deg^2) optical images reaching a 5 sigma limit of ~26 magnitude, about 100 times deeper than the Sloan Digital Sky Survey (SDSS). To select Z/Z_sun<0.1 EMPGs from ~40 million sources detected in the Subaru images, we first develop a machine-learning (ML) classifier based on a deep neural network algorithm with a training data set consisting of optical photometry of galaxy, star, and QSO models. We test our ML classifier with SDSS objects having spectroscopic metallicity measurements, and confirm that our ML classifier accomplishes 86%-completeness and 46%-purity EMPG classifications with photometric data. Applying our ML classifier to the photometric data of the Subaru sources as well as faint SDSS objects with no spectroscopic data, we obtain 27 and 86 EMPG candidates from the Subaru and SDSS photometric data, respectively. We conduct optical follow-up spectroscopy for 10 out of our EMPG candidates with Magellan/LDSS-3+MagE, Keck/DEIMOS, and Subaru/FOCAS, and find that the 10 EMPG candidates are star-forming galaxies at z=0.007-0.03 with large H_beta equivalent widths of 104-265 A, stellar masses of log(M*/M_sun)=5.0-7.1, and high specific star-formation rates of ~300 Gyr^{-1}, which are similar to those of early galaxies at z>6 reported recently. We spectroscopically confirm that 3 out of 10 candidates are truly EMPGs with Z/Z_sun<0.1, one of which is HSC J1631+4426, the most metal-poor galaxy with Z/Z_sun=0.016 reported ever.Comment: 30 pages, 26 figures, and 8 tables; (Revision: metallicities changed due to the use of a more pricise dust correction method, but conclusion does not change, Minor: a table, some figures, and sentences are added for a clear explanation.

EMPRESS. IX. Extremely Metal-Poor Galaxies are Very Gas-Rich Dispersion-Dominated Systems: Will JWST Witness Gaseous Turbulent High-z Primordial Galaxies?

We present kinematics of 6 local extremely metal-poor galaxies (EMPGs) with low metallicities ($0.016-0.098\ Z_{\odot}$) and low stellar masses ($10^{4.7}-10^{7.6} M_{\odot}$). Taking deep medium-high resolution ($R\sim7500$) integral-field spectra with 8.2-m Subaru, we resolve the small inner velocity gradients and dispersions of the EMPGs with H$\alpha$ emission. Carefully masking out sub-structures originated by inflow and/or outflow, we fit 3-dimensional disk models to the observed H$\alpha$ flux, velocity, and velocity-dispersion maps. All the EMPGs show rotational velocities ($v_{\rm rot}$) of 5--23 km s$^{-1}$ smaller than the velocity dispersions ($\sigma_{0}$) of 17--31 km s$^{-1}$, indicating dispersion-dominated ($v_{\rm rot}/\sigma_{0}=0.29-0.80<1$) systems affected by inflow and/or outflow. Except for two EMPGs with large uncertainties, we find that the EMPGs have very large gas-mass fractions of $f_{\rm gas}\simeq 0.9-1.0$. Comparing our results with other H$\alpha$ kinematics studies, we find that $v_{\rm rot}/\sigma_{0}$ decreases and $f_{\rm gas}$ increases with decreasing metallicity, decreasing stellar mass, and increasing specific star-formation rate. We also find that simulated high-$z$ ($z\sim 7$) forming galaxies have gas fractions and dynamics similar to the observed EMPGs. Our EMPG observations and the simulations suggest that primordial galaxies are gas-rich dispersion-dominated systems, which would be identified by the forthcoming James Webb Space Telescope (JWST) observations at $z\sim 7$.Comment: Submitted to ApJ; After revisio