Early Results of a Wildfire Monitoring Microsatellite UNIFORM-1

UNIFORM (UNiversity International FORmation Mission) is a capacity building program in microsatellite field including satellites, ground stations, and data platform. The program, sponsored by the Ministry of Education, Culture, Sports and Technology (MEXT) of Japan, aims to increase the number of players in the small satellite community through education of both domestic and international young engineers, by providing them with an opportunity to study, build, and operate microsatellites. The first satellite of the program, UNIFORM-1 was launched on May 24th 2014. UNIFORM-1 is a 50-kg earth observation satellite whose mission is wildfiremonitoring using a microbolometer. Since then it has been in operation, successfully capturing several events on the ground including wildfires and volcanic activities. This paper presents in-orbit results of UNIFORM-1 mission, critical bus subsystems including EPS and AOCS, and lessons learned from its operations

Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer.

金沢大学新学術創成研究機構ナノ生命科学研究所Embargo Period 12 month

Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases.

A Darwinian evolutionary shift occurs early in the neutral evolution of advanced colorectal carcinoma (CRC), and copy number aberrations (CNA) are essential in the transition from adenoma to carcinoma. In light of this primary evolution, we investigated the evolutionary principles of the genome that foster postoperative recurrence of CRC. CNA and neoantigens (NAG) were compared between early primary tumors with recurrence (CRCR) and early primary tumors without recurrence (precancerous and early; PCRC). We compared CNA, single nucleotide variance (SNV), RNA sequences, and T-cell receptor (TCR) repertoire between 9 primary and 10 metastatic sites from 10 CRCR cases. We found that NAG in primary sites were fewer in CRCR than in PCRC, while the arm level CNA were significantly higher in primary sites in CRCR than in PCRC. Further, a comparison of genomic aberrations of primary and metastatic conditions revealed no significant differences in CNA. The driver mutations in recurrence were the trunk of the evolutionary phylogenic tree from primary sites to recurrence sites. Notably, PD-1 and TIM3, T cell exhaustion-related molecules of the tumor immune response, were abundantly expressed in metastatic sites compared to primary sites along with the increased number of CD8 expressing cells. The postoperative recurrence-free survival period was only significantly associated with the NAG levels and TCR repertoire diversity in metastatic sites. Therefore, CNA with diminished NAG and diverse TCR repertoire in pre-metastatic sites may determine postoperative recurrence of CRC