EFFECT OF TOPICAL HUMIC ACID ON EXCISIONAL PALATAL WOUND HEALING: A HISTOPATHOLOGICAL AND HISTOMORPHOMETRIC STUDY IN RATS

Background: The purpose of the present study was to examine the effects of topical humic acid application on healing in oral mucosa wound in rats. Material and Methods A total of 12-week-old 72 Wistar male rats weighing 280-300 gr were used in the study. The rats were randomly grouped in 4 groups as the Control Group (K) to which no applications were made, Chlorhexidine (0.12%) Group (CHX), 80 mg/kg Humic Acid Group (HA80), and 150 mg/kg Humic Acid Group (HA150). Mucosal defects of 5-mm-diameter were induced with punch in the palatal areas of the rats. These groups were further divided into 3 sub-groups to be sacrificed on days 7, 14 and 21. Epithelization, ülceration, polymorphic nuclear leukocytes (PNL), mononuclear cells (MNL), fibroblast and vascularization were examined in histopathologic evaluations. In addition, photos of the tissue samples were taken and transferred to the computer medium for histo-morphometric examinations. Results As a result of the statistical analyses, no significant differences were detected among the groups in terms of epithelization degree, PNL and MNL cell infiltration on days 7, 14 and 21. The ulcerated areas were low in HA150 Group compared to the other groups, and there was a significant difference in this respect (p<0.05). Vascularization degrees were evaluated, the K Group and HA150 Group showed better results on day 7 (p<0.05). On days 14 and 21, no significant differences were detected among the groups (p>0.05). Wound area measurement scores were lower in HA150 Group compared to the other groups, and this result showed that the healing in HA150 Group was better (p<0.05). Conclusions As a result of the present study, it was found that humic acid increased wound healing in oral cavity

Protetik tedavilerde lazerlerin kullanımı

Bu çalışmanın amacı lazer teknolojilerinin protetik tedavilere nasıl entegre edilebileceğini ve diş hekimliğinde kullanılan materyaller üzerindeki etkilerini tartışmaktır. Bu derleme, protetik tedavide kullanılan lazer çeşitlerini, lazer parametrelerini ve bunların materyaller olan etkileşimlerini inceleyen bilimsel çalışmaları kapsamaktadır

Ana modelin elde edilmesinde vakumlu kabin tekniği

Amaç: Bu çalışmanın amacı farklı karıştırma ve döküm tekniklerinin alçının fiziksel özellikleri üzerine etkisini karşılaştırmaktır. Gereç ve Yöntemler: Çalışma planı iki yönlü olarak düzenlenmiştir; farklı karıştırma tekniklerinin alçının fiziksel özellikleri ve kalitesi üzerine etkisini incelemek. Örnekler karıştırma tekniklerine göre dört gruba ayrıldı: El ile karıştırma (Grup H), vakumlu mikser ile karıştırma (Grup VM), vakumlu kabin ile karıştırma (Grup VK), vakumlu mikser ve sonrasında vakumlu kabin kombinasyonu(Grup VM/VK) . Altmış örnek, üç nokta bükülme testi için hazırlandı. Model kırıklıkları kaydedilerek Kruskal-Wallis istatistik testi ile analiz edildi. Alt çene fantom akrilik dişler (Diş No: 43, 42, 41, 31, 32, 33) shoulder basamaklı metal desteksiz seramik veneer kron preparasyonu yapıldı ve ölçü alındı. Ana model üzerindeki poroziteler x40 büyütmeli mikroskop altında incelendi. Sonuçlar analizi için Tek Yönlü Varyans Analiz (α = 0.05) yöntemi kullanıldı. Bulgular: Sonuçlar göster, VM/VK tekniğinin modeldeki poroziteyi anlamlı ölçüde (p < 0.05) azalttığını ve modelin dayanım derecesini arttırdığını göstermiştir. En yüksek dayanım değeri Grup VM/VK' da (31.8 ± 0.7 MPa) oluşurken en az dayanım değeri Grup H' de (20.8 ± 0.1 MPa) oluştu. Sonuç: Vakumlu kabin ve vakumlu mikser tekniği ile kombinasyonu ana model dayanıklılığını arttırır ve poroziteyi azaltır. Bundan dolayı bu teknik ana modellerin dökülmesi için düzenli olarak kullanılabilir

Breast artery calcification as an opportunistic predictor of cardiovascular disease

Background Atherosclerotic cardiovascular disease is still the leading cause of mortality for women. Breast cancer screening with mammography is recommended in all women aged over 40 years. Aims Whether breast artery calcification (BAC) is associated with cardiovascular disease is not clear. We aimed to evaluate the association between BAC and the presence of coronary atherosclerosis determined by CT. Methods All patients who underwent both mammography and coronary CT angiography between January 2010 and December 2016 were screened, and patients with a duration of less than 12 months between CT and mammography were included. Results A total of 320 women were included and BAC was detected in 47 (14.6%) patients. BAC was correlated with age and CT coronary calcium score. Both the frequency of critical coronary artery stenosis (34% vs 10.6%; p = 0.001) and CT coronary calcium score (5.5 vs 0; p = 0.001) was significantly higher in patients with BAC. The absence of BAC was a strong predictor of the absence of significant coronary artery disease (p = 0.001). BAC was independently associated with all-cause mortality after excluding patients with breast cancer (HR: 5.32; p = 0.013). Conclusion Breast artery calcification is associated with coronary calcium score and significant coronary stenosis. A high BAC score is related to increased mortality