Confirmation of PSMA expression measured on [68Ga]Ga-PSMA PET/CT by immunohistochemistry in prostate adenocarcinoma

Background: Our aim is to determine the accuracy of [68Ga]Ga-PSMA PET/CT in showing PSMA expression in primary prostate cancer and to investigate the relationship between SUVmax and immunohistochemical PSMA expression, Gleason score, and PSA value. Material and methods: We retrospectively analyzed 66 male patients who were diagnosed with primary prostate adenocarcinoma, underwent pre-treatment [68Ga]Ga-PSMA PET/CT examination for staging, and performed radical prostatectomy between March 2018–August 2020. Immunohistochemical staining was applied to the radical prostatectomy specimens of all patients to detect PSMA expression. The results were evaluated as an immunoreactive score (IRS) and a modified IRS was obtained. Gleason score groups and prostate-specific antigen (PSA) serum values of the patients were obtained from the patient files. Results: The high SUVmax of primary prostate tumors was significantly correlated with a high modified IRS score (score 2; 3), high PSA value, high Gleason score, and metastasis. In correlation analysis, a positive correlation was found between SUVmax and PSA value and modified IRS score (r = 0.69, p = 0.001; r = 0.39, p = 0.001). In addition, there was a statistically significant weak correlation between PSA serum concentration and modified IRS scores (r = 0.267; p = 0.03). In regression analysis, the percentage of positive cells had a statistically significant and increasing effect on SUVmax (p = 0.031; std beta = 0.268; 95% CI = 0.231–4.596). Conclusions: In prostate adenocarcinoma, SUVmax of the primary tumor in [68Ga]Ga-PSMA PET/CT correlates with immunohistochemical PSMA expression. In addition, high SUVmax is associated with markers of poor prognoses, such as high PSMA expression, PSA value, and Gleason score

Efficacy of perineal electrical stimulation in men with urinary incontinence after radical prostatectomy. A prospective randomized controlled trial

Objective To evaluate the efficacy of perineal electrical stimulation (ES) on anxiety, depression, incontinence-related quality of life (QoL), and clinical parameters in men with urinary incontinence (UI) after radical prostatectomy (RP). Methods Fifty-eight men with UI after RP were randomized into two groups using the random numbers generator as follows: Group 1 received perineal ES (n:29), and Group 2 no treatment (n:29). Perineal ES was performed in lithotomy position via a stimulation device (Enraf Myomed 632) with surface electrodes, 3 days a week, 20 min a day, for a total of 24 sessions for 8 weeks. Men were evaluated in terms of continence rates (primary outcome), incontinence severity (24 h-pad test), incontinence episodes (3-day bladder diary), anxiety-depression (HADS), QoL (IIQ-7), and improvement rates and treatment satisfaction (Likert scale) at the baseline and the end of treatment (8th week). Results A statistically significant improvement was found in all parameters except depression in Group 1, in the severity of incontinence and QoL parameters in Group 2 at the 8th week compared to the baseline values (p 0.05). At the end of treatment; the severity of incontinence, incontinence episodes, QoL, and anxiety were significantly improved in Group 1 compared to Group 2 (p 0.05). No difference was found between the two groups in terms of depression (p > 0.05). The continence and improvement rates and treatment satisfaction were significantly higher in Group 1 than in Group 2 (p 0.05). Conclusion Perineal ES is more effective than no treatment in men with UI after RP as an alternative ES option that is well tolerated and does not produce serious adverse events. Clinical Trial Registration: This study was registered with number, NCT05236140

Radikal sistektomi sonrası ileal konduit ile kontinan diversiyon uygulanan hastalardaki yaşam kalitesi değerlendirilmesi

Amaç: Mesane kanseri sık görülen kanserler arasındadır. Mesane kanseri evresine ve hastanın tercihine göre tedavi seçenekleri bulunmaktadır. Kasa invaze mesane kanserinde altın standart tedavi radikal sistektomidir. Uygulanan tedavi hastaların sağlığını etkilediği kadar, yaşam kalitesini de etkilemektedir. Yaşam kalitesini etkileyen en önemli parametrenin de uygulanan üriner diversiyon olduğu düşünülmektedir. Bizde kliniğimizde takipli hastalarda üriner diversiyonun yaşam kalitesi üzerine etkilerini saptamayı amaçladık. Gereç ve yöntem: Çalışmamıza 2007-2015 yılları arasında radikal sistektomi operasyonu geçiren 107 hastadan, en az 1 yıllık takibi bulunan ve çalışmaya katılmayı kabul eden (Grup 1) 32 ileal loop üriner diversiyon ve (Grup 2) 21 kontinan üriner diversiyon uygulan toplam 53 hasta alındı. Hastaların demografik ve klinik verileri Retrospektif olarak elde edildi. Yaşam kalitesi verileri için yüz yüze anket uygulaması ile Türkçe validasyonları yapılmış Short Form-36 (SF-36), Avrupa Kanser Araştırma ve Tedavi Merkezi tarafından geliştirilen EORTC QLQ-C30 ve Beck Depresyon Ölçeği uygulandı. Bulgular: Çalışmaya katılan hastalara operasyon kararı alırken onkolojik prensiplerden taviz vermeden preoperatif böbrek dilatasyonu olan hastalara daha çok ileal loop üriner diversiyon uygulandığı, vücut kitle indeksi düşük olanlara da kontinan üriner diversiyon uygulandığı saptanmıştır. Gruplar arasında SF-36 ve EORTC QLQ-C30 yaşam analizi değerlendirmesinde fark olmadığı, Beck depresyon ölçeğinin ise Grup 1’de (7,8±6,1) Grup 2’ye (4,7±5,2) (p0,05) göre daha yüksek olarak bulundu. Sonuç: Tedavide hangi diversiyon türü seçilirse seçilsin onkolojik prensiplerden taviz verilmemesi gerektiği esestır. Bu prensip hastaya anlatılmalıdır. Hastanın diversiyon türlerine yönelik bilgilendirilmesi ve özellikle ileal loop seçimi ön planda ise depresyona yatkınlığının preoperatif olarak değerlendirilmesi gerektiği kanaatindeyiz

A short course of antimicrobial therapy for asymptomatic bacteriuria is safe and effective before urologic procedures

Introduction: In the presence of asymptomatic bacteriuria (ASB) before the urological procedure, the duration of antimicrobial treatment is controversial. This study aims to evaluate whether a short course of antimicrobial therapy is safe and effective in cases with ASB before urological procedures. Methodology: We retrospectively reviewed adult patients who had ASB before undergoing several urological procedures between 2011 and 2019. The patients received a single dose of an appropriate parenteral antibiotic, determined by antimicrobial sensitivity testing, 30 to 60 minutes before the urological procedure. If a urinary catheter was placed post-procedure, a second dose was given. Results: A total of 293 patients who had ASB before undergoing several urological procedures were included in the study. The total number of procedures was 328. Female/male ratio was 92 (31.4%)/201 (68.6%). The mean age was 63.7 +/- 14.9 years. The most common isolated microorganisms were Escherichia coli (155 [47%]), Klebsiella pneumoniae (38 [11.6%]), and Pseudomonas aeruginosa (28 [8.5%]). The most common antimicrobial used was ertapenem. A second dose antimicrobial was given for 290 procedures due to a urinary catheter after a urological procedure. The mean hospitalization time was 3.97 +/- 3.42 days. None of the patients developed infectious complications. Conclusions: This study has demonstrated that a single dose of parenteral antimicrobial drug administered 30-60 minutes before the urologic procedures and a second dose in the presence of a post-procedure catheter, was adequate to prevent post-procedure septicemia and urinary tract infection