The role of islamic lifestyle on social security in Russia

Despite the historical realm of security, this concept has been proposed as a social issue only in the modern era and has been tried to be studied empirically. In fact, Islam has considered social security as an important principle in human life and has made other issues dependent on social security. Therefore, the most important issue of urbanisation is social security. Those who commit social offences often do not have a positive view of their society and sometimes of the whole creation and regard social systems and sometimes the universe unhealthy and deviating. In addition, they think that they cannot obtain their true right in an acceptable and natural routine. Islam, along with warning and fear, which can eliminate the root and origin of sin and deviation, has emphasised and encouraged the heavenly reward and worldly happiness. Therefore, the present study aimed to determine the role of Islamic lifestyle in social security in Volga Region in Russia. Hence, 10 000 citizens were selected as the statistical population by simple random sampling method. The data have been analysed by Linear Structural Relations (LISREL) software. The participants’ opinions indicated that the Islamic lifestyle plays a significant role in improving social security (P = 0.756; T = 12.453). Therefore, by implementing Islamic teachings in their lives, one will not only have a balanced and meaningful personal life but also security, order and participation will establish social life and society. Contribution: This article contributes to the role of Islamic lifestyle in social security in Volga Region in Russia

P53 long noncoding RNA regulatory network in cancer development

The protein p53 as a transcription factor with strong tumor-suppressive activities is known to trigger apoptosis via multiple pathways and is directly involved in the recognition of DNA damage and DNA repair processes. P53 alteration is now recognized as a common event in the pathogenesis of many types of human malignancies. Deregulation of tumor suppressor p53 pathways plays an important role in the activation of cell proliferation or inactivation of apoptotic cell death during carcinogenesis and tumor progression. Mounting evidence indicates that the p53 status of tumors and also the regulatory functions of p53 may be relevant to the long noncoding RNAs (lncRNA)-dependent gene regulation programs. Besides coding genes, lncRNAs that do not encode for proteins are induced or suppressed by p53 transcriptional response and thus control cancer progression. LncRNAs also have emerged as key regulators that impinge on the p53 signaling network orchestrating global gene-expression profile. Studies have suggested that aberrant expression of lncRNAs as a molecular-genomic signature may play important roles in cancer biology. Accordingly, it is important to elucidate the mechanisms by which the crosstalk between lncRNAs and p53 occurs in the development of numerous cancers. Here, we review how several classes of lncRNAs and p53 pathways are linked together in controlling the cell cycle and apoptosis in various cancer cells in both human and mouse model systems