Polarizations of Gravitational Waves in Horndeski Theory

We analyze the polarization content of gravitational waves in Horndeski theory. Besides the familiar plus and cross polarizations in Einstein's General Relativity, there is one more polarization state which is the mixture of the transverse breathing and longitudinal polarizations.The additional mode is excited by the massive scalar field. In the massless limit, the longitudinal polarization disappears, while the breathing one persists. The upper bound on the graviton mass severely constrains the amplitude of the longitudinal polarization, which makes its detection highly unlikely by the ground-based or space-borne interferometers in the near future. However, pulsar timing arrays might be able to detect the polarization excited by the massive scalar field. Since additional polarization states appear in alternative theories of gravity, the measurement of the polarizations of gravitational waves can be used to probe the nature of gravity. In addition to the plus and cross states, the detection of the breathing polarization means that gravitation is mediated by massless spin 2 and spin 0 fields, and the detection of both the breathing and longitudinal states means that gravitation is propagated by the massless spin 2 and massive spin 0 fields.Comment: 15 two column pages, 6 captioned figures, EPJC in pres

Enhancing regulatory T-cell function via inhibition of high mobility group box 1 protein signaling in immune thrombocytopenia

Primary immune thrombocytopenia (ITP) is the most common acquired autoimmune bleeding disorder. Abnormally increased levels of High Mobility Group Box 1 (HMGB1) protein associate with thrombocytopenia and therapeutic outcome in ITP. Previous studies proposed that a natural inhibitor of HMGB1, 18β-glycyrrhetinic acid (18β-GA), could be used for its anti-inflammatory and immune-modulatory effects, although its ability to correct immune balance in ITP is unclear. In this study, we showed that plasma HMGB1 correlated negatively with platelet counts in ITP patients, and confirmed that 18β-GA stimulated the production of regulatory T cells (Treg), restored the balance of CD4+ T-cell subsets and enhanced the suppressive function of Treg through blocking the effect on HMGB1 in patients with ITP. HMGB1 short hairpin RNA interference masked the effect of 18β-GA in Treg of ITP patients. Furthermore, we found that 18β-GA alleviated thrombocytopenia in mice with ITP. Briefly, anti-CD61 immune-sensitized splenocytes were transferred into severe combined immunodeficient mice to induce a murine model of severe ITP. The proportion of circulating Treg increased significantly, while the level of plasma HMGB1 and serum antiplatelet antibodies decreased significantly in ITP mice along 18β-GA treatment. In addition, 18β-GA reduced phagocytic activity of macrophages towards platelets both in ITP patients and ITP mice. These results indicate that 18β-GA has the potential to restore immune balance in ITP via inhibition of HMGB1 signaling. In short, this study reveals the role of HMGB1 in ITP, which may serve as a potential target for thrombocytopenia therapy

Study of the Law of Hydraulically Punched Boreholes on Effective Gas Extraction Radius under Different Coal Outputs

Hydraulic punching technology has recently developed into an effective pressure relief measure and permeability enhancement method for soft and low permeability coalbeds. Different coal outputs directly affect the shape and size of boreholes as well as the effective extraction radius. Taking the Zhongmacun mine as an example, the influence of different coal outputs and different extraction periods on effective extraction radius was analyzed and studied through field tests and numerical simulation. The results show that the increase in coal outputs from hydraulic punching can improve the effective extraction radius of the boreholes. For example, when the gas extraction reaches 90 days, with a coal output of 0.5 t/m, 1.0 t/m, and 1.5 t/m, the effective extraction radius is 3.08 m, 3.46 m, and 3.83 m, respectively. The difference in gas extraction effect of different coal output boreholes increases significantly with the extension of the extraction time, but the speed of growth gradually decreases, which is consistent with the conclusions obtained on-site. This result has important practical significance for optimizing the technical parameters of hydraulic punching, guiding the accurate layout of extraction and drilling, and enhancing the effect of gas control in mines

miR-126 Functions as a Tumor Suppressor in Osteosarcoma by Targeting Sox2

Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults, the early symptoms and signs of which are non-specific. The discovery of microRNAs (miRNAs) provides a new avenue for the early diagnosis and treatment of OS. miR-126 has been reported to be highly expressed in vascularized tissues, and is recently widely studied in cancers. Herein, we explored the expression and significance of miR-126 in OS. Using TaqMan RT-PCR analysis, we analyzed the expression of miR-126 in 32 paired OS tumor tissues and 4 OS cell lines and found that miR-126 was consistently under-expressed in OS tissues and cell lines compared with normal bone tissues and normal osteoblast cells (NHOst), respectively. As miR-126 is significantly decreased in OS tissues and cell lines, we sought to compensate for its loss through exogenous transfection into MG-63 cells with a miR-126 mimic. Ectopic expression of miR-126 inhibited cell proliferation, migration and invasion, and induced apoptosis of MG-63 cells. Moreover, bioinformatic prediction suggested that the sex-determining region Y-box 2 (Sox2) is a target gene of miR-126. Using mRNA and protein expression analysis, luciferase assays and rescue assays, we demonstrate that restored expression of Sox2 dampened miR-126-mediated suppression of tumor progression, which suggests the important role of miR-126/Sox2 interaction in tumor progression. Taken together, our data indicate that miR-126 functions as a tumor suppressor in OS, which exerts its activity by suppressing the expression of Sox2

Interfacial passivation engineering for highly efficient quantum dot light-emitting diodes via aromatic amine-functionalized dipole molecules

Blue quantum dot (QD) light-emitting diodes (QLEDs) exhibit unsatisfactory operational stability and electroluminescence (EL) properties due to severe nonradiative recombination induced by large numbers of dangling bond defects and charge imbalance in QD. Herein, dipolar aromatic amine-functionalized molecules with different molecular polarities are employed to regulate charge transport and passivate interfacial defects between QD and the electron transfer layer (ETL). The results show that the stronger the molecular polarity, especially with the −CF3 groups possessing a strong electron-withdrawing capacity, the more effective the defect passivation of S and Zn dangling bonds at the QD surface. Moreover, the dipole interlayer can effectively reduce electron injection into QD at high current density, enhancing charge balance and mitigating Joule heat. Finally, blue QLEDs exhibit a peak external quantum efficiency (EQE) of 21.02% with an operational lifetime (T50 at 100 cd m–2) exceeding 4000 h

Retraction: Yang, C., et al. miR-126 Functions as a Tumor Suppressor in Osteosarcoma by Targeting Sox2. <i>Int. J. Mol. Sci.</i> 2014, <i>15</i>, 423–437, doi:10.3390/ijms15010423

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