Entire Peroxidation Reaction System of Myeloperoxidase Correlates with Progressive Low-Density Lipoprotein Modifications via Reactive Aldehydes in Atherosclerotic Patients with Hypertension

Background/Aims: Reactive oxygen species (ROS) contribute to the dysfunction of serum lipoproteins, which triggers lipid metabolism abnormalities in the development of atherosclerosis and hypertension. Myeloperoxidase (MPO) is involved in ROS modifications, triggering lipid peroxidation and aldehyde formation. However, the relationship between the entirety of the MPO reaction system and oxidative modification of serum lipoproteins in atherosclerotic patients with hypertension remains unclear. Methods: We measured MPO activity (peroxidation and chlorination), 4-hydroxynonenal-modified low-density lipoprotein (HNE-LDL), malondialdehyde-modified low-density lipoprotein (MDA-LDL), H2O2, reduced glutathione (GSH), and oxidized glutathione (GSSG) using a corresponding commercial kit in atherosclerotic patients with hypertension and healthy participants. We used Spearman’s correlation analysis to investigate the correlation between MPO activity and the levels of these oxidative and anti-oxidative stress-related indices and performed response surface regression to investigate the relationship between the MPO reaction system and the levels of HNE-LDL, MDA-LDL, and the GSH/GSSG ratio. Results: Our results showed no association between the levels of MPO peroxidation activity, MPO chlorination activity, H2O2, and Cl- and those of HNE-LDL, MDA-LDL, GSH, and GSSG, and the GSH/GSSG ratio in healthy participants. In addition, no effects of the peroxidation reaction system of MPO (PRSM) and the chlorination reaction system of MPO (CRSM) on GSH/GSSG were found in this investigation. However, we found that the PRSM rather than the CRSM correlated with progressive low-density lipoprotein (LDL) modifications by HNE-LDL and MDA-LDL in atherosclerotic patients with hypertension. Conclusion: The PRSM rather than the CRSM correlated with progressive LDL modifications via reactive aldehydes in atherosclerotic patients with hypertension. Further investigation is warranted to evaluate whether the PRSM may serve as a potential index for monitoring LDL function in atherosclerosis and hypertension

A heterozygous moth genome provides insights into herbivory and detoxification

How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants1, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood2. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.Minsheng You … Simon W Baxter … et al

Incorporating suburban cropland into urban green infrastructure: A perspective of nature-based solutions in China

Urban green infrastructure (GI) addresses human social development issues and challenges through urban green space ecosystem services. However, the ecosystem service functions of suburban cropland, especially regulating services and cultural services, have been seriously underestimated. The distribution of green spaces and suburban cropland varies in different regions of China, as well as their potential development methods. This article examines the potential of integrating suburban cropland into urban green infrastructure, offering a perspective on nature-based solutions in China. We divided the suburban cropland in China into three parts: peri‑suburban, mid-suburban, and outer-suburban by the concept of 15-minute living circle based on different travel modes of people. Based on statistical yearbook data, satellite remote sensing images and the fragstats 4.2 programme, a quantitative analysis was conducted on the spatial distribution, landscape pattern and social development of suburban farmland and green space in four cities. Then, the potential for improving the exposure level of suburban cropland after incorporating suburban cropland into urban green infrastructure was quantified and compared. Finally, we explored the potential development of the three kinds of suburban cropland as green infrastructure based on the concept of NbS. We found the spatial pattern of cropland and green space in the mid-suburban is greatly affected by regional geographical conditions, the green exposure level, i.e., green space availability indicators, in Beijing, Shanghai, Guangzhou, and Xi'an increased by 83 %, 300 %, 24 %, and 612 %, respectively, after incorporating suburban cropland into urban green infrastructure. The potential development models for suburban cropland should be based on NbS and China's national conditions: peri‑suburban cropland should be fully utilized for cultural and social functions, the mid-suburban cropland should focus on multifunctional utilization of cropland, and the outer-suburban is prioritized for ecological functions. Our study provides scientific insights for deep exploration of the functions of suburban cropland in China

Dynamic Impacts of Climate and Land-Use Changes on Surface Runoff in the Mountainous Region of the Haihe River Basin, China

The relative contributions of different factors to the variation in surface runoff have been broadly quantified. However, little attention has been paid to how these relative contributions have changed over time. We analyzed the changes in surface runoff during 1980–2010 in six subbasins in the mountainous region of the Haihe River Basin, one of the most serious water shortage regions in China, and identified the changes in the relative contributions of climate (precipitation and temperature) and land-use to surface runoff decrease. There was a decreasing tendency in surface runoff in all subbasins, four of which had an abrupt change point around 1998. Comparing the relative contributions before and after 1998 in the four subbasins, the average influence of climate was found to decline dramatically from 67.1% to 30.5%, while that of land-use increased from 23.9% to 69.5% mainly due to the increase of forest area. Our results revealed that the primary environmental factor responsible for runoff variations was not constant, and an alternation may accentuate the impact and stimulate an abrupt change of runoff in semiarid and semihumid mountainous regions. This will help in taking tracking measures to deal with the complex water resource challenges according to different driving factors

Calibration Method of Array Errors for Wideband MIMO Imaging Radar Based on Multiple Prominent Targets

Wideband multiple-input-multiple-output (MIMO) imaging radar can achieve high-resolution imaging with a specific multi-antenna structure. However, its imaging performance is severely affected by the array errors, including the inter-channel errors and the position errors of all the transmitting and receiving elements (TEs/REs). Conventional calibration methods are suitable for the narrow-band signal model, and cannot separate the element position errors from the array errors. This paper proposes a method for estimating and compensating the array errors of wideband MIMO imaging radar based on multiple prominent targets. Firstly, a high-precision target position estimation method is proposed to acquire the prominent targets’ positions without other equipment. Secondly, the inter-channel amplitude and delay errors are estimated by solving an equation-constrained least square problem. After this, the element position errors are estimated with the genetic algorithm to eliminate the spatial-variant error phase. Finally, the feasibility and correctness of this method are validated with both simulated and experimental datasets

An Improved Multi-Baseline Phase Unwrapping Method for GB-InSAR

Ground-based interferometric synthetic aperture radar (GB-InSAR) technology can be applied to generate a digital elevation model (DEM) with high spatial resolution and high accuracy. Phase unwrapping is a critical procedure, and unwrapping errors cannot be effectively avoided in the interferometric measurements of terrains with discontinuous heights. In this paper, an improved multi-baseline phase unwrapping (MB PU) method for GB-InSAR is proposed. This method combines the advantages of the cluster-analysis-based MB PU algorithm and the minimum cost flow (MCF) method. A cluster-analysis-based MB PU algorithm (CA-based MB PU) is firstly utilized to unwrap the clustered pixels with high phase quality. Under the topological constraints of a triangulation network, the connectivity graph of any non-clustered pixel is established with its adjacent unwrapped cluster pixels. Then, the absolute phase of these non-clustered pixels can be identified using the MCF method. Additionally, a spatial-distribution-based denoising algorithm is utilized to denoise the data in order to further improve the accuracy of the phase unwrapping. The DEM generated by one GB-InSAR is compared with that generated by light detection and ranging (LiDAR). Both simulated and experimental datasets are utilized to verify the effectiveness and robustness of this improved method

An Improved Multi-Baseline Phase Unwrapping Method for GB-InSAR

Ground-based interferometric synthetic aperture radar (GB-InSAR) technology can be applied to generate a digital elevation model (DEM) with high spatial resolution and high accuracy. Phase unwrapping is a critical procedure, and unwrapping errors cannot be effectively avoided in the interferometric measurements of terrains with discontinuous heights. In this paper, an improved multi-baseline phase unwrapping (MB PU) method for GB-InSAR is proposed. This method combines the advantages of the cluster-analysis-based MB PU algorithm and the minimum cost flow (MCF) method. A cluster-analysis-based MB PU algorithm (CA-based MB PU) is firstly utilized to unwrap the clustered pixels with high phase quality. Under the topological constraints of a triangulation network, the connectivity graph of any non-clustered pixel is established with its adjacent unwrapped cluster pixels. Then, the absolute phase of these non-clustered pixels can be identified using the MCF method. Additionally, a spatial-distribution-based denoising algorithm is utilized to denoise the data in order to further improve the accuracy of the phase unwrapping. The DEM generated by one GB-InSAR is compared with that generated by light detection and ranging (LiDAR). Both simulated and experimental datasets are utilized to verify the effectiveness and robustness of this improved method

Research on Strong Clutter Suppression for Gaofen-3 Dual-Channel SAR/GMTI

In spaceborne synthetic aperture radar (SAR), moving targets are almost buried in ground clutter due to the wide clutter Doppler spectrum and the restricted pulse repetition frequency (PRF), which increases the difficulty of moving target detection. Clutter suppression is one of the key issues in the spaceborne SAR moving target indicator operation. In this paper, we describe the clutter suppression principle and analyze the influence of amplitude and phase error on clutter suppression. In the following, a novel dual-channel SAR clutter suppression algorithm is proposed, which is suitable for the Gaofen-3(GF-3) SAR sensor. The proposed algorithm consists of three technique steps, namely adaptive two-dimensional (2D) channel calibration, refined amplitude error correction and refined phase error correction. After channel error is corrected by these procedures, the clutter component, especially a strong clutter component, can be well suppressed. The validity of the proposed algorithm is verified by GF-3 SAR real data which demonstrates the ground moving-target indication (GMTI) capability of GF-3 SAR sensor