1,459 research outputs found

    A Trade-Off Proposal for Funding Long-Term Care

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    Long-term care can be a depressing subject. Most of us tend not to think about it. However, we cannot long avoid it as the 76 million baby boomers begin reaching older ages in a few short years. According to projections, in 40 years, those aged 65 to 84 (numbering 31.6 million in 2005) will more than double, and those 85 plus (about 5.1 million in 2005), who are more at risk of dependency, will more than triple (U.S. Census Bureau, 2004 and 2006). Heavy reliance on Medicaid, already the second largest budget item in most states, would not appear viable. If we could design better ways of paying for it, perhaps more of us would be inclined to plan. And plan we should

    Employee Preferences as a Factor in Pension Participation by Minority Workers

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    This project was designed to shed light on the widening gap between white and minority pension coverage during recent years. The hypothesis under investigation is that the divergence in white/minority coverage may be due in part to differences in the rates at which white and minority workers are choosing to participate in voluntary salary reduction plans. The availability of such plans has increased explosively in the past decade or so

    Implications of Changing Social Norms for Social Security Benefits: Results of Pilot Research

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    Problem. The U.S. Social Security program is designed to protect the American family structure that existed when the program was introduced in the 1930s. Both family structure and social norms regarding family life have changed substantially in the interim. Major changes in family structure invite proposals to modify Social Security benefits to accommodate contemporary conditions. To remain politically viable, the program must make adjustments to reflect contemporary public opinion regarding family life. We asked to what extent contemporary public opinion is supportive of the current benefit structure and the extent to which public opinion points to possible changes in benefits? Methods. We explored the feasibility of using factorial survey designs to determine public opinion about Social Security benefits. In this method, respondents are asked to make judgments about vignettes that describe specific situations. Specific vignettes are generated randomly from a vignette structure that includes both a set of dimensions and specific conditions within each dimension. Each respondent is asked to judge a set of vignettes. Through multivariate statistical analysis, the effects of vignette structure on judgments are determined. The project was concerned with the feasibility of applying this method in studying the normative underpinnings of Social Security benefits. Results of two pilot studies are reported. One study was concerned with survivor benefits; the second was concerned with pensions at normal retirement age. Respondents were undergraduate students. Findings. Overall, the research showed that the factorial survey is a promising method of measuring public opinion regarding Social Security benefits. In the study of survivor benefits, the research found public support, for example, for current policy regarding the presence of 2 minor children in the home for the eligibility of surviving widows or widowers for benefits. However, respondents were less likely to recommend benefits for surviving spouses with undesirable social characteristics. Under current policy, the “worthiness” of survivors is not taken into consideration in determination of benefits. In the study of retirement benefits, the findings show support for the policy of basing pensions heavily on numbers of years of contributions to the system. However, the findings point to possible reform by showing support for providing Social Security credits to full-time unpaid providers of elder care. Further research with more representative samples is needed both to determine whether the current findings can be generalized and to examine other issues concerning Social Security benefits

    Bronchioloalveolar carcinoma

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    AbstractBronchioloalveolar carcinoma is a subtype of adenocarcinoma of the lung with a relatively better prognosis. We reviewed the cases of 50 consecutive patients with bronchioloalveolar carcinoma treated during a 10-year period and attempted to analyze factors related to prognosis. During the 10-year study period, the prevalence of bronchioloalveolar carcinoma relative to adenocarcinoma of the lung remained steady. The subjects included 32 male and 18 female patients with mean ages of 64.7 years and 55.1 years, respectively (p = 0.0030). The preoperative radiographic findings included 40 cases of localized and 10 cases of diffuse bronchioloalveolar carcinoma. The clinicopathologic TNM staging included 20 patients with stage I cancer, 4 with stage II cancer, 11 with stage IIIa cancer, 3 with stage IIIb cancer, and 12 with stage IV cancer. Forty patients with clinical stage I, II, or III disease underwent operation (operability 80%). The resectability rate was 90% (36 of 40). Thirty-four procedures were considered as curative. The overall cumulative survival at 5 years was 22.2% (46.4% for stage I). Different TNM stages showed significant differences in survival time (p = 0.0001). The median survival times were 64.6 months for stage I, 48.0 months for stage II, 24.7 months for stage IIIa, 9.0 months for stage IIIb, and 4.5 months for stage IV disease. The median survival time for localized bronchioloalveolar carcinoma was 27.5 months, and the median survival time for diffuse bronchioloalveolar carcinoma was 4.3 months (p = 0.0002). The median survival time for the curative resection group was 30.6 months, and the median survival time for the noncurative resection or nonresection group was 5.8 months (p = 0.0001). On the basis of this study we conclude that (1) the prevalence of bronchioloalveolar carcinoma is quite steady, (2) bronchioloalveolar carcinoma presents at an earlier age in women, (3) bronchioloalveolar carcinoma frequently presents with lymphatic spread or systemic metastasis at diagnosis, (4) most localized bronchioloalveolar carcinomas are resectable and the prognosis with this type is better than that of the diffuse type, and (5) long-term survival correlates closely with initial roentgenographic appearance, TNM stage, and completeness of surgical resection. (J THORAC CARDIOVASC SURG 1995;110:374-81

    Effects of Planting Density on Visually Graded Lumber and Mechanical Properties of Taiwania

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    The purpose of this study was to investigate the effects of planting density on the quality of visually graded lumber, and the strength properties of 35-year-old Taiwania (Taiwania cryptomerioides Hay). The results are summarized as follows.(1) Lumber obtained from the site with type S planting density (6940 trees/ha) were mostly of better grade (84.6% including first and second grades), followed by type Q (2500 trees/ha) (69.1%), type R (3300 trees/ha) (62.5%), whereas poorer lumber was found mostly from trees with type P planting density (1000 trees/ha) (41.6%).(2) Specimens cut from trees of type S planting density site had the largest average values of ultrasonic velocity (Vu), dynamic modulus of elasticity obtained from transversal vibration (Edt), dynamic modulus of elasticity obtained from ultrasonic velocity (Edu), modulus of elasticity at bending (MOE), and modulus of rupture at bending (MOR), followed in decreasing order by those of type P, type R, and type Q sites.(3) Interrelations between Vu, Edu, Edt, MOE, and MOR can be represented by positive linear regression formulas. The differences were highly significant

    Integrin-mediated membrane blebbing is dependent on the NHE1 and NCX1 activities.

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    Integrin-mediated signal transduction and membrane blebbing have been well studied to modulate cell adhesion, spreading and migration^1-6^. However, the relationship between membrane blebbing and integrin signaling has not been explored. Here we show that integrin-ligand interaction induces membrane blebbing and membrane permeability change. We found that sodium-proton exchanger 1 (NHE1) and sodium-calcium exchanger 1 (NCX1) are located in the membrane blebbing sites and inhibition of NHE1 disrupts membrane blebbing and decreases membrane permeability change. However, inhibition of NCX1 enhances cell blebbing to cause cell swelling which is correlated with an intracellular sodium accumulation induced by NHE17. These data suggest that sodium influx induced by NHE1 is a driving force for membrane blebbing growth, while sodium efflux induced by NCX1 in a reverse mode causes membrane blebbing retraction. Together, these data reveal a novel function of NHE1 and NCX1 in membrane permeability change and blebbing and provide the link for integrin signaling and membrane blebbing

    The complete primary structure of abrin-a B chain

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    AbstractThe complete 267 amino acid sequence of abrin-a B chain was determined by analysis of peptides obtained by digestion with trypsin, chymotrypsin, lysyl endopeptidase, Staphylacaccus aureus V8 protease and thermolysin. The sequence is not identical with that predicted previously by nucleotide sequencing, indicating the presence of isoforms of abrin. Comparison of the amino acid sequence of abrin-a B chain with that of ricin-D B chain reveals a high degree of sequence identity (59%). Abrin-a B chain appears to consist of two domains, each domain with subdomains (α, β, γ) of about 40 amino acid residues

    Simulation of Riding a Full Suspension Bicycle for Analyzing Comfort and Pedaling Force

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    AbstractRecently, there is an increasing interest on bicycle riding for recreation or fitness purpose. Bicycles are also accepted as urban transportation due to the consciousness of environmental protection. For a more comfortable riding experience, many bicycles are equipped with a suspension system including a front suspension fork and/or rear suspension. However, when a suspension system is added to a bicycle, it makes riding a little heavier since suspension dissipates some pedalling energy. This paper discusses front and rear suspensions corresponding to rider comfort and pedalling effort when riding on a rough road and smooth road. A human body computer model LifeMOD® is employed to model the cyclist. Dynamic analysis software ADAMS® is employed to analyze human body vibration and leg muscle forces of bicycle riding. Human body acceleration vs. vibration frequencies are used as the comfort criteria. The results show that a suspension system may effectively reduce high frequency vibration of the human body when riding on a rough road. Pedalling forces are mostly contributed by the biceps femoris and semitendinosus. The suspension system would increase the pedaling forces of femoris and semitendinosus. Other leg muscles have a minor effect on pedaling forces. Results obtained from this research are useful for the design of bicycle suspension systems with better comfort and less loss of pedalling efficiency
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