Topology and phase transition for EPYM AdS black hole in thermal potential

As we all know the local topological properties of thermodynamical systems can be expressed by the winding numbers as the defects. The topological number that is the sum of all winding numbers can be used to classify the global topological nature of thermodynamical systems. In this paper, we construct a kind of thermal potential and then put the Einstein-power-Yang-Mills AdS black hole in it. Through the analysis of the geometric characteristics of the thermal potential based on the complex analysis we find the topological number is an invariant that is same as shown in the way of the Duan's $\phi$-mapping topological current [Sci. Sin. 9, 1072 (1979)]. Furthermore, we adopt the Kramer's escape rate method to investigate the intensity of the first-order phase transition

Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro

Clinical attempts to reduce the cardiotoxicity of arsenic trioxide (ATO) without compromising its anticancer activities remain to be an unresolved issue. In this study, we determined whether Sal B can protect against ATO-induced cardiac toxicity in vivo and increase the toxicity of ATO toward cancer cells. Combination treatment of Sal B and ATO was investigated using BALB/c mice and human hepatoma (HepG2) cells and human cervical cancer (HeLa) cells. The results showed that the combination treatment significantly improved the ATO-induced loss of cardiac function, attenuated damage of cardiomyocytic structure, and suppressed the ATO-induced release of cardiac enzymes into serum in BALB/c mouse models. The expression levels of Bcl-2 and p-Akt in the mice treated with ATO alone were reduced, whereas those in the mice given the combination treatment were similar to those in the control mice. Moreover, the combination treatment significantly enhanced the ATO-induced cytotoxicity and apoptosis of HepG2 cells and HeLa cells. Increases in apoptotic marker cleaved poly (ADP-ribose) polymerase and decreases in procaspase-3 expressions were observed through western blot. Taken together, these observations indicate that the combination treatment of Sal B and ATO is potentially applicable for treating cancer with reduced cardiotoxic side effects