Parking Space Management via Dynamic Performance-Based Pricing

In congested urban areas, it remains a pressing challenge to reduce unnecessary vehicle circling for parking while at the same time maximize parking space utilization. In observance of new information technologies that have become readily accessible to drivers and parking agencies, we develop a dynamic non-cooperative bi-level model (i.e. Stackelberg leader-follower game) to set parking prices in real-time for effective parking access and space utilization. The model is expected to fit into an integrated parking pricing and management system, where parking reservations and transactions are facilitated by sensing and informatics infrastructures, that ensures the availability of convenient spaces at equilibrium market prices. It is shown with numerical examples that the proposed dynamic parking pricing model has the potential to virtually eliminate vehicle circling for parking, which results in significant reduction in adverse socioeconomic externalities such as traffic congestion and emissions

Is epinephrine still the drug of choice during cardiac arrest in the emergency department of the hospital? A meta-analysis

Epinephrine is the first-line emergency drug for cardiac arrest and anaphylactic reactions but is reported to be associated with many challenges resulting in its under- or improper utilization. Therefore, in this meta-analysis, the efficacy and safety of epinephrine as a first-line cardiac emergency drug for both out-of-hospital and in-hospital patients was assessed. Pertinent articles were searched in central databases like PubMed, Scopus, and Web of Science, using appropriate keywords as per the PRISMA guidelines. Retrospective and prospective studies were included according to the predefined PICOS criteria. RevMan and MedCalc software were used and statistical parameters such as odds ratio and risk ratio were calculated. Twelve clinical trials with a total of 208,690 cardiac arrest patients from 2000 to 2022 were included, in accordance with the chosen inclusion criteria. In the present meta-analysis, a high odds ratio (OR) value of 3.67 (95 % CI 2.32–5.81) with a tau2 value of 0.64, a chi2 value of 12,446.86, df value of 11, I2 value of 100 %, Z-value 5.53, and a p-value < 0.00001 were reported. Similarly, the risk ratio of 1.89 (95 % CI 1.47–2.43) with a tau2 value of 0.19, chi2 value of 11,530.67, df value of 11, I2 value of 100 %, Z-value of 4.95, and p-value < 0.000001. The present meta-analysis strongly prefers epinephrine injection as the first cardiac emergency drug for both out-of-hospital and in-hospital patients during cardiac arrest

Optimal Pavement Design and Rehabilitation Planning Using a Mechanistic-Empirical Approach

This paper presents the development of a pavement design and rehabilitation optimization decision-making framework based on Mechanistic-Empirical (ME) roughness transfer models. The AASHTOWare Pavement ME Design (the software of Pavement ME Design) is used to estimate pavement deterioration based on the combined effects of permanent deformation, fatigue, and thermal cracking. The optimization problem is first formulated into a mixed-integer nonlinear programming model to address the predominant trade-off between agency and user costs. To deal with the complexity associated with the pavement roughness transfer functions in the software and to use the roughness values as input to the optimization framework, a dynamic programming subroutine is developed for determining the optimal rehabilitation timing and asphalt concrete design thickness. An application of the proposed model is demonstrated in a case study. Managerial insights from a series of sensitivity analyses on different unit user cost values and model comparisons are presented

Pre-set extrusion bioprinting for multiscale heterogeneous tissue structure fabrication

Recent advances in three-dimensional bioprinting technology have led to various attempts in fabricating human tissue-like structures. However, current bioprinting technologies have limitations for creating native tissue-like structures. To resolve these issues, we developed a new pre-set extrusion bioprinting technique that can create heterogeneous, multicellular, and multimaterial structures simultaneously. The key to this ability lies in the use of a precursor cartridge that can stably preserve a multimaterial with a pre-defined configuration that can be simply embedded in a syringe-based printer head. The multimaterial can be printed and miniaturized through a micro-nozzle without conspicuous deformation according to the pre-defined configuration of the precursor cartridge. Using this system, we fabricated heterogeneous tissue-like structures such as spinal cords, hepatic lobule, blood vessels, and capillaries. We further obtained a heterogeneous patterned model that embeds HepG2 cells with endothelial cells in a hepatic lobule-like structure. In comparison with homogeneous and heterogeneous cell printing, the heterogeneous patterned model showed a well-organized hepatic lobule structure and higher enzyme activity of CYP3A4. Therefore, this pre-set extrusion bioprinting method could be widely used in the fabrication of a variety of artificial and functional tissues or organs

IL-22–producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

IL-22 plays an important role in mucosal epithelial cell homeostasis. Using a dextran sodium sulfate-induced mouse model of acute colitis, we observed an IL-23–dependent up-regulation of IL-22 in the middle and distal colon at the onset of epithelial cell damage. This heightened IL-22 correlated with an influx of innate immune cells, suggesting an important role in colonic epithelial protection. Freshly isolated colon-infiltrating neutrophils produced IL-22 contingent upon IL-23 signaling, and IL-22 production was augmented by TNF-α. Importantly, the depletion of neutrophils resulted in diminished IL-22 levels in the colon, and the transfer of IL-22–competent neutrophils to Il22a-deficient mice protected the colonic epithelium from dextran sodium sulfate-induced damage. In addition, IL-22–producing neutrophils targeted colonic epithelial cells to up-regulate the antimicrobial peptides, RegIIIβ and S100A8. This study establishes a role for neutrophils in providing IL-22–dependent mucosal epithelial support that contributes to the resolution of colitis

Effect of anion co-existence on ionic organic pollutants removal over Ca based layered double hydroxide

The effects of co-existing anions (NO or SO ) on the removal of sodium dodecylsulfate (SDS), representing anionic organic pollutants, by Ca-based layered double hydroxide (CaAl-LDH-Cl) are investigated to provide fundamental insights on the ionic surfactant removal in the presence of co-existing anions, and facilitate the establishment of a practical and advanced water treatment for environmental remediation. The SO system shows higher adsorption capacity (4.43 mmol·g) and larger d-spacing of adsorption resultant (3.4 nm) than the control system with no co-existing anion (3.64 mmol·g, 3.25 nm) and the NO system (3.82 mmol·g, 3.27 nm). The macroscopic and microscopic analyses reveal that, NO had a little influence on the SDS removal due to strong electrolysis, while SO could significantly promote the SDS removal. Moreover, the reaction mechanism varies under different molar ratios of DS/SO