Acute effects of elevated NEFA on vascular function: a comparison of SFA and MUFA

There is emerging evidence to show that high levels of NEFA contribute to endothelial dysfunction and impaired insulin sensitivity. However, the impact of NEFA composition remains unclear. A total of ten healthy men consumed test drinks containing 50 g of palm stearin (rich in SFA) or high-oleic sunflower oil (rich in MUFA) on separate occasions; a third day included no fat as a control. The fats were emulsified into chocolate drinks and given as a bolus (approximately 10 g fat) at baseline followed by smaller amounts (approximately 3 g fat) every 30 min throughout the 6 h study day. An intravenous heparin infusion was initiated 2 h after the bolus, which resulted in a three- to fourfold increase in circulating NEFA level from baseline. Mean arterial stiffness as measured by digital volume pulse was higher during the consumption of SFA (P,0·001) but not MUFA (P¼0·089) compared with the control. Overall insulin and gastric inhibitory peptide response was greater during the consumption of both fats compared with the control (P,0·001); there was a second insulin peak in response to MUFA unlike SFA. Consumption of SFA resulted in higher levels of soluble intercellular adhesion molecule-1 (sI-CAM) at 330 min than that of MUFA or control (P#0·048). There was no effect of the test drinks on glucose, total nitrite, plasminogen activator inhibitor-1 or endothelin-1 concentrations. The present study indicates a potential negative impact of elevated NEFA derived from the consumption of SFA on arterial stiffness and sI-CAM levels. More studies are needed to fully investigate the impact of NEFA composition on risk factors for CVD

Spectral dimensions of hierarchical scale-free networks with shortcuts

The spectral dimension has been widely used to understand transport properties on regular and fractal lattices. Nevertheless, it has been little studied for complex networks such as scale-free and small world networks. Here we study the spectral dimension and the return-to-origin probability of random walks on hierarchical scale-free networks, which can be either fractals or non-fractals depending on the weight of shortcuts. Applying the renormalization group (RG) approach to the Gaussian model, we obtain the spectral dimension exactly. While the spectral dimension varies between $1$ and $2$ for the fractal case, it remains at $2$, independent of the variation of network structure for the non-fractal case. The crossover behavior between the two cases is studied through the RG flow analysis. The analytic results are confirmed by simulation results and their implications for the architecture of complex systems are discussed.Comment: 10 pages, 3 figure

Calculating the transfer function of noise removal by principal component analysis and application to AzTEC observations

Instruments using arrays of many bolometers have become increasingly common in the past decade. The maps produced by such instruments typically include the filtering effects of the instrument as well as those from subsequent steps performed in the reduction of the data. Therefore interpretation of the maps is dependent upon accurately calculating the transfer function of the chosen reduction technique on the signal of interest. Many of these instruments use non-linear and iterative techniques to reduce their data because such methods can offer improved signal-to-noise over those that are purely linear, particularly for signals at scales comparable to that subtended by the array. We discuss a general approach for measuring the transfer function of principal component analysis (PCA) on point sources that are small compared to the spatial extent seen by any single bolometer within the array. The results are applied to previously released AzTEC catalogues of the COSMOS, Lockman Hole, Subaru XMM-Newton Deep Field, GOODS-North and GOODS-South fields. Source flux density and noise estimates increase by roughly +10 per cent for fields observed while AzTEC was installed at the Atacama Submillimeter Telescope Experiment and +15-25 per cent while AzTEC was installed at the James Clerk Maxwell Telescope. Detection significance is, on average, unaffected by the revised technique. The revised photometry technique will be used in subsequent AzTEC releases.Comment: 14 pages, 4 figure

Discovery of ram-pressure stripped gas around an elliptical galaxy in Abell 2670

Studies of cluster galaxies are increasingly finding galaxies with spectacular one-sided tails of gas and young stars, suggestive of intense ram-pressure stripping. These so-called "jellyfish" galaxies typically have late-type morphology. In this paper, we present MUSE observations of an elliptical galaxy in Abell 2670 with long tails of material visible in the optical spectra, as well as blobs with tadpole-like morphology. The spectra in the central part of the galaxy reveals a stellar component as well as ionized gas. The stellar component does not have significant rotation, while the ionized gas defines a clear star-forming gas disk. We argue, based on deep optical images of the galaxy, that the gas was most likely acquired during a past wet merger. It is possible that the star-forming blobs are also remnants of the merger. In addition, the direction and kinematics of the one-sided ionized tails, combined with the tadpole morphology of the star-forming blobs, strongly suggests that the system is undergoing ram pressure from the intracluster medium. In summary, this paper presents the discovery of a post-merger elliptical galaxy undergoing ram pressure stripping.Comment: 6 pages, 5 figures, accepted for publication in ApJ