A new dynamical mechanism of incomplete fusion in heavy-ion collision

The incomplete fusion has been proved as the formation and emission of the $\alpha$ particle by the increase in the rotational energy of the very mass-asymmetric dinuclear system. The results of the dinuclear system model have confirmed that the incomplete fusion in heavy-ion collisions occurs at a large orbital angular momentum ($L > 30 \hbar$) due to the strong increase of the intrinsic fusion barrier.Comment: 6 pages, 11 figure

Blood Pressure Variability: Marker or Predictor of Cardiovascular Risk?

Background: Regardless of the mean blood pressure value, short-term and long-term BP variability (BPV) are associated with the development and progression of target organ damage and predictors of cardiovascular complications and mortality. The purpose of the present study was to evaluate the prognostic significance of increased BPV in patients with arterial hypertension (AH). Methods and Results: The study consisted of two stages. In the first stage, a retrospective analysis of 365 ABPM results was carried out. As a result of the analysis, 271 patients aged 56.1±10.0 years with uncontrolled AH Grades 1-3 (ESC/ESH, 2018) were included in this study. Depending on the values of BPV, AH patients were divided into two groups: Group 1 consisted of patients with normal BPV (n=145), and Group 2 consisted of patients with increased BPV (n=126). The second stage included 91 patients with uncontrolled hypertension without permanent antihypertensive therapy who had increased BPV. We found statistically significant differences in BP between the AH patients with normal BPV and increased BPV. Thus, in the group with normal BPV, compared with increased BPV, the parameters of the average 24-h systolic BP (SBP), daytime SBP, and nighttime SBP were statistically lower (141±14.6 vs. 147.2±20.2 mmHg, P<0.004; 142.8±15.1 vs. 148.4±20.7 mmHg, P<0.01; and 136.2±15.5 vs. 143.8±21.4 mmHg, P<0.001; respectively). A statistically significant moderate direct correlation was found between the average 24-h SBP and the average 24-h and daytime SBP variability (SBPV) (rs=0.49 and rs=0.40 respectively, P<0.001 in all cases). A statistically significant moderate to weak direct correlation also was found between the average daytime SBP, and the average 24-h and daytime SBPV (rs=0.45 and rs=0.37, respectively, P<0.001 in all cases). A moderate direct correlation was found between nighttime SBP and 24-hour SBPV (rs=0.52, P<0.001) and between nighttime SBP and daytime SBPV (rs=0.42, P<0.001). Weak direct correlations were found between the average 24-h SBPV and central SBP (SBPc) (rs=0.34, P<0.001), as well as between the average 24-h and daytime SBPV and central pulse pressure (PPc) (rs=0.33 and rs=0.32, respectively, P<0.001 in all cases). A weak direct correlation was found between carotid intima-media thickness (CIMT) and the average 24-h and daytime SBPV (rs=0.37 [P<0.001] and rs=0.3 [P=0.04]). Conclusion: The increased BPV is associated with impaired diurnal blood pressure profile (DBPP) and structural and functional changes in blood vessels, in particular, an increase in SBPc and PP in the aorta, and CIMT thickening, which characterizes increased BPV as a predictor of vascular remodeling in patients with uncontrolled AH

Interaction of certain α-dicarbonyl compounds with ethanedithiol and steric structure of the products formed

1. 1-Phenylpropane-1,2-dione gives a bis-1,3-dithiolane derivative in the reaction with 1,2-ethanedithiol, analogously to glyoxal and phenylglyoxaL Diacetyl and benzil give the corresponding monomercaptals. 2. 1-Phenylpropane-1,2-dione is reduced in the reaction with 1,2-ethanedithiol, forming 2-ethyl-2-phenyl-1, 3-dithiolane, 3. Bis-1,3-dithiolane derivatives of 1-phenylpropane-1, 2-dione, glyoxal, and phenylglyoxal exist in the gauche-form; 2-keto-l,3-dithiolanes from diacetyl and benzil have shielded structures with predominance of the S-conformer. © 1974 Consultants Bureau

Conformation of 2-aryl groups in 1, 3-dioxanes

On the basis of the data of the method of dipole moments and the Kerr effect, 2-(p-X-phenyl)-1, 3-dioxanes and 5, 5-dichloro-2-(p-X-phenyl)-1,3-dioxanes, where X=Cl or NO2, have a chair conformation with an equatorial phenyl group, the plane of which coincides with the plane of symmetry of the dioxane ring. © 1975 Plenum Publishing Corporation

Sulfate group polarization and polarizability and the conformations of the dimethyl sulfates

1. Polarity and polarizability parameters have been determined for the sulfate group. 2. In solution, the dimethylsulfate molecule shows trans-trans conformation of the C-O-S-O-C chain. © 1977 Plenum Publishing CorporationPlenum Publishing Corporation

Conformations of acyclic sulfites

1. Dialkyl sulfites in liquids, vapors, and solutions are represented by structures with trans-trans- and trans-gauche-conformations of the chain R-O-S-O-R. 2. Diaryl sulfites exist in a trans-gauche conformation. © 1974 Consultants Bureau

Conformations of certain ethylene ketals with vicinal C-Hal bonds

The g⇌t equilibrium is displaced toward the less polar gauche form in the ethylene ketals of 2-chlorocyclohexanone and 2-bromocyclohexanone, and in the chloro- and bromoacetaldehydes. © 1978 Plenum Publishing Corporation

The Kinetics and Mechanism of the Sulfur Dioxide Oxidation by the Oxygen in the Presence of the Cobalt and Nickel Complexes, Fixed on Polymer Matrix

Catalytic sulphur dioxide oxidation by oxygen on the cobalt and nickel complexes fixed on polyetheleneamine was investigated. On the base of kinetics study it was established that SO2 and oxygen interact in inner sphere mechanism. UV-spectra and quantum-chemical calculations are presented, and on the base of them the ways of oxygen activation are discussed

Reaction of sulfur halides with unsaturated compounds - Communication 12. Stereochemistry of the oxidation of 2,9-dichloro-13-thiabicyclo[8.2.1]cis-5-tridecene

Oxidation of 2,9-dichloro-13-thiabicyclo[8.2.1]cis-5-tridecene with tert-amyl hydroperoxide leads to the respective exo-sulfoxide and also to a derivative of 13-thiabicyclo[7.3.1]cis-5-tridecene, which is a product from rearrangement with enlargement of the thiacyclopentane ring to a thiacyclohexane ring. © 1976 Plenum Publishing Corporation

Clinical Effectiveness of the Fixed‐Dose vs Free‐Dose Triple Combinations in Patients with Uncontrolled Arterial Hypertension

Background: The purpose of our study was a comparative assessment of the antihypertensive effectiveness of 2 triple combination antihypertensive therapy (AHT) regimens in a free-dose and fixed-dose combination of perindopril, indapamide, and amlodipine in hypertensive patients with high cardiovascular risk and a poor response to the 2-drug combinations in the clinic practice. Methods and Results: Our study included 143 patients (79 men and 88 women) with arterial hypertension (AH) Grades 1-3 (ESC/ESH, 2018) and high cardiovascular risk who did not achieve the target blood pressure (TBP) on dual combination AHT. The mean age of patients was 55.76±9.35 years; the average duration of AH was 10.69±6.61 years. All patients underwent the examinations according to the 2018 ESC/ESH Guidelines for the management of arterial hypertension. Patients included in the study were divided into 2 groups using the envelope method: Group 1 (n=84) received a fixed-dose, triple combination of perindopril, indapamide, and amlodipine; Group 2 (n=83) received a free-dose combination of these drugs. In both groups, treatment began after discontinuation of previous therapy, with a low dose of a triple combination of antihypertensive drugs (perindopril [5 mg/day], indapamide [1.25 mg/day], amlodipine [5 mg/day]) in the form of a fixed or free combination. The initial doses of perindopril/indapamide/amlodipine in both groups were not statistically different: 6.9±2.4/1.74±0.6/7.1±2.4mg/day in Group 1 and 6.9±2.7/1.95±0.6/7.1±2.5 mg/day in Group 2. After 4 weeks of therapy, if necessary, the doses of drugs were increased, starting with perindopril; the next adjustment of drug doses was carried out after 12 weeks of therapy. The final treatment results were determined after 24 weeks of AHT. Target blood pressure (TBP) of <140/90 mmHg was reached by 94.4% of patients in Group 1 and 83.3% in Group 2 (χ²=7.471, Р=0,006); TBP of <130/80 mmHg was reached by 70% of patients in Group 1 and 42% in Group 2 (χ²=11.61, Р=0,0001). A significant improvement in the diurnal BP profile was also revealed during treatment. According to ABPM data, both groups achieved TBP in terms of the average 24-h and average daytime systolic blood pressure (SBP) and diastolic blood pressure (DBP). Regarding average nighttime SBP and DBP and normalization of average nighttime diastolic blood pressure variability, target values were achieved only in Group 1(P=0.028). In both groups, 24-week triple-combination therapy led to a significant decrease in central SBP, central DBP, and pulse wave velocity (PWV). At the same time, the positive dynamics of central SBP were more pronounced in Group 1 than in Group 2 (Table 4), and PWV in Group 1 reached standard values. Conclusion: The results of our study showed that in the treatment of uncontrolled hypertension on previous therapy in AH patients with high cardiovascular risk, a single-pill triple combination of the ACEI perindopril, the CCB amlodipine, and the thiazide-like diuretic indapamide contributed to the effective daily blood pressure control, the improvement of diurnal blood pressure profile, and a positive effect on central blood pressure and PWV, thereby having a positive impact on the prognosis and quality of life of AH patients with high cardiovascular risk