Development and verification of wall-flap-gate as tsunami inundation defence for nuclear plants

A wall-flap-gate is automatic watertight door, and it works by buoyancy without powered machineries and human operations. In the Tohoku Earthquake tsunamis, serious damages were caused by inundation from ventilators of outer walls in power plants. The wall-flap-gate is estimated to be effective in keeping sustainability of nuclear plants against extreme tsunamis. The present study examines the hydrodynamic characteristics of the wall-flap-gate by hydraulic model experiments and verifies its capability of flood prevention for nuclear plants through various prototype tests. The experimental results proved that the wall-flap-gate had sufficient strength, watertightness, and durability against tsunamis and that its motion was not disturbed by debris. The viability of the wall-flap-gate as an inundation defence structure for nuclear plants was confirmed through this study. As a result, practical wall-flap-gates are installing on Hamaoka nuclear power station in Shizuoka prefecture, Japan

Roentgenographic Study of the Chest of the Aged: special reference to "senile lung" and the paraspinal line

The characteristics of the changes of "senile lung" and normal values of the width of the paraspinal shadows on the chest roentgenographs were studied among 235 subjects aged from 70 to 97 without frank chest diseases. The ratio of upper transverse diameter (at the level of posterior 6th rib) to lower transverse diameter (at the top of right hemidiaphragm) on the frontal radiographs was significantly higher over the age of 85 than under 84, only in the female subjects. However, a lack of differences could be found in males. Therefore, "senile lung" was considered to be characteristic of the aging process, only for women. The width of the paraspinal shadow over the age of 70 was estimated to be normal in up to 19.9mm, and the index divided by the distance of descending aorta was up to 0.61, obtained from the value of 99% confidence limits

A Case of Acquired Leucoderma, Associated with Hashimoto's Thyroiditis

A 67-year-old female diagnosed as Hashimoto's thyroiditis in company with acquired leucoderma was reported. She first noticed the enlarged thyroid at the age of 36, and thereafter leucoderma made its appearance 30 years later. Though a significant association between these two diseases has been found in the literature thus far and they are considered to be of autoimmune origin, their coexistence is not so common clinically. In spite of PUVA treatment, a benefit effect was not obtained completely

Impact of renal insufficiency on long-term clinical outcome in patients with heart failure treated by cardiac resynchronization therapy

AbstractBackgroundRenal insufficiency is recognized as a predictor of mortality and adverse outcome in heart failure (HF) patients. However, the long-term clinical outcome of cardiac resynchronization therapy (CRT) in Japanese HF patients with renal insufficiency remains uncertain.MethodsWe evaluated 67 consecutive patients who underwent CRT at our hospital. The patients were divided into two groups according to a baseline estimated glomerular filtration rate (e-GFR) cut-off value of 50ml/min, which is defined as the time at which patients should be referred to a nephrologist, by the Japanese Society of Nephrology. Follow-up echocardiographic findings and renal function were examined at 3–6 months after CRT. Then, we compared long-term clinical outcomes between the two groups, and analyzed the effect of CRT on renal function, echocardiographic parameters and cardiac survival.ResultsDuring a mean follow-up period of 30.3 months, patients with advanced renal insufficiency (e-GFR<50ml/min) had significant higher all-cause mortality (log-rank p=0.033) and higher cardiac mortality combined with HF hospitalization (log-rank p=0.017) than patients with e-GFR≥50ml/min. Multivariate analysis revealed that advanced renal insufficiency was an independent predictor of cardiac mortality combined with HF hospitalization (odds ratio=3.01, p=0.008). Subgroup analysis in the baseline advanced renal insufficiency group revealed that patients with preserved renal function by CRT (<10% reduction in e-GFR) had a higher rate of decrease of left ventricular end-systolic diameter (−14.0% vs. −0.8%, p=0.023) and lower cardiac mortality combined with HF hospitalization (log-rank p=0.029) compared with patients with deterioration of renal function (≥10% reduction in e-GFR).ConclusionsThe present study suggests that advanced renal insufficiency is quite useful for the prediction of worsening clinical outcomes in HF patients treated by CRT. Preservation of renal function by CRT brings about better cardiac survival through prevention of adverse cardiac events, even in HF patients with advanced renal insufficiency

Suzaku observation of Jupiter's X-rays around solar maximum

We report on results of imaging and spectral studies of X-ray emission from Jupiter observed by Suzaku. In 2006 Suzaku had found diffuse X-ray emission in 1\unicode{x2013}5 keV associated with Jovian inner radiation belts. It has been suggested that the emission is caused by the inverse-Compton scattering by ultra-relativistic electrons ($\sim 50$ MeV) in Jupiter's magnetosphere. To confirm the existence of this emission and to understand its relation to the solar activity, we conducted an additional Suzaku observation in 2014 around the maximum of the 24th solar cycle. As a result, we successfully found again the diffuse emission around Jupiter in 1\unicode{x2013}5 keV and also point-like emission in 0.4\unicode{x2013}1 keV. The luminosity of the point-like emission which was probably composed of solar X-ray scattering, charge exchange, or auroral bremsstrahlung emission increased by a factor of $\sim 5$ with respect to 2006, most likely due to an increase of the solar activity. The diffuse emission spectrum in the 1\unicode{x2013}5 keV band was well-fitted with a flat power-law function ($\Gamma = 1.4 \pm 0.1$) as in the past observation, which supported the inverse-Compton scattering hypothesis. However, its spatial distribution changed from $\sim 12 \times 4$ Jovian radius (Rj) to $\sim 20 \times 7$ Rj. The luminosity of the diffuse emission increased by a smaller factor of $\sim 3$. This indicates that the diffuse emission is not simply responding to the solar activity, which is also known to cause little effect on the distribution of high-energy electrons around Jupiter. Further sensitive study of the spatial and spectral distributions of the diffuse hard X-ray emission is important to understand how high-energy particles are accelerated in Jupiter's magnetosphere.Comment: 17 pages, 4 figures, 1 tabl

Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

筋ジストロフィーのゲノム編集治療を目指したLNP-mRNA輸送システムの開発. 京都大学プレスリリース. 2021-12-08.Nanotechnology for genome editing in multiple muscles simultaneously. 京都大学プレスリリース. 2021-12-08.Genome editing therapy for Duchenne muscular dystrophy (DMD) holds great promise, however, one major obstacle is delivery of the CRISPR-Cas9/sgRNA system to skeletal muscle tissues. In general, AAV vectors are used for in vivo delivery, but AAV injections cannot be repeated because of neutralization antibodies. Here we report a chemically defined lipid nanoparticle (LNP) system which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle by repeated intramuscular injections. Although the expressions of Cas9 protein and sgRNA were transient, our LNP system could induce stable genomic exon skipping and restore dystrophin protein in a DMD mouse model that harbors a humanized exon sequence. Furthermore, administration of our LNP via limb perfusion method enables to target multiple muscle groups. The repeated administration and low immunogenicity of our LNP system are promising features for a delivery vehicle of CRISPR-Cas9 to treat skeletal muscle disorders

Effect of Focal X-ray Irradiation on Experimental Choroidal Neovascularization

PURPOSE. Radiation therapy has been used to treat choroidal neovascularization (CNV) in patients with age-related macular degeneration. The in vivo effect of applying focal x-ray irradiation to the eye of rabbits with experimental CNV was investigated. METHODS. CNV was induced in the rabbit eyes by subretinal implantation of gelatin hydrogel microspheres impregnated with basic fibroblast growth factor. Three weeks after implantation, 17 of 34 eyes with CNV lesions accompanied by fluorescein leakage were irradiated with a single dose of 20 Gy; the other 17 eyes were not irradiated and served as the controls. The eyes were examined before irradiation and 1, 2, and 4 weeks after irradiation, by indirect ophthalmoscopy and fluorescein angiography. The degree of a decreasing amount of fluorescein leakage from the CNV lesions after irradiation was graded using a computerized image analysis system and was compared in the irradiated and nonirradiated eyes. These eyes were also examined histologically and immunohistochemically. RESULTS. Fluorescein leakage from the CNV lesions had significantly decreased in the eyes irradiated with 20 Gy compared with the control eyes, throughout the study period (P &lt; 0.05). Histologic and immunohistochemical studies at 4 weeks after irradiation demonstrated that the degree of vascular formation and the number of vascular endothelial cells in the subretinal membrane of the irradiated eyes were less than those of the control eyes. CONCLUSIONS. Focal x-ray irradiation at the ocular region effectively reduced experimental CNV activity. These results support the possibility that radiation therapy may be beneficial in treating CNV. (Invest Ophthalmol Vis Set. 1999;40:l496-1502

A Normal Range of KL-6/MUC1 Independent of Elevated SP-D Indicates a Better Prognosis in the Patients with Honeycombing on High-Resolution Computed Tomography

Both SP-D and KL-6/MUC1 are established biomarkers of the interstitial pneumonias, including idiopathic pulmonary fibrosis (IPF), but the causes and clinical outcomes based on their independent effects are not known. Eleven asymptomatic patients, detected with honeycombing on high-resolution computed tomography (HRCT), were compared with 17 other IPF outpatients having slight respiratory symptoms and honeycombing as well. Although SP-D was increased in both groups, KL-6 was significantly higher in the symptomatic IPF group. When the patients (n = 11) having both biomarkers elevated were compared with the other patients (n = 6) with only SP-D elevated, the distribution of fibrotic lesions with honeycombing on HRCT was larger and the survival time was shorter in the patients having both biomarkers elevated. Immunohistochemical analysis also differentiated these biomarkers in the lung. These results suggest both a cause and the prognostic value of dissociation of these biomarkers