35 research outputs found
Chlamydia trachomatis infection in early neonatal period
BACKGROUND: The clinical characteristics of Chlamydia trachomatis respiratory tract infections in Japanese neonates were investigated. METHODS: Clinical, laboratory and microbiological characteristics of five infants with pneumonia due to C. trachomatis in early neonatal period were analyzed. RESULTS: Only C. trachomatis was identified in 4 infants. Both C. trachomatis and cytomegalovirus was identified in one. Wheezing, tachypnea and cyanosis were common in infants. Mothers of five infants had negative chlamydial EIAs at 20 weeks of gestation. CONCLUSIONS: We identified five cases of C. trachomatis respiratory tract infections in early neonatal period with the possibility of intrauterine infection. Targeted screening, early diagnosis, and effective treatment of perinatal and neonatal chlamydial infections seems to be necessar
Wide and Deep Exploration of Radio Galaxies with Subaru HSC (WERGS). III. Discovery of a z = 4.72 Radio Galaxy with Lyman Break Technique
We report a discovery of radio galaxy, HSC J083913.17+011308.1, by
using the Lyman break technique with the Hyper Suprime-Cam Subaru Strategic
Survey (HSC-SSP) catalog for VLA FIRST radio sources. The number of known
high- radio galaxies (HzRGs) at is quite small to constrain the
evolution of HzRGs so far. The deep and wide-area optical survey by HSC-SSP
enables us to apply the Lyman break technique to a large search for HzRGs. For
an HzRG candidate among pre-selected -band dropouts with a radio detection,
a follow-up optical spectroscopy with GMOS/Gemini has been performed. The
obtained spectrum presents a clear Ly emission line redshifted to
. The SED fitting analysis with the rest-frame UV and optical
photometries suggests the massive nature of this HzRG with . The small equivalent width of Ly and the moderately red UV
colors indicate its dusty host galaxy, implying a chemically evolved and dusty
system. The radio spectral index does not meet a criterion for an ultra-steep
spectrum: of and of ,
demonstrating that the HSC-SSP survey compensates for a sub-population of HzRGs
which are missed in surveys focusing on an ultra-steep spectral index.Comment: 10 pages, 5 figures, accepted for publication in A
Subaru high-z exploration of low-luminosity quasars (SHELLQs). I. Discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9
We report the discovery of 15 quasars and bright galaxies at 5.7 < z < 6.9.
This is the initial result from the Subaru High-z Exploration of Low-Luminosity
Quasars (SHELLQs) project, which exploits the exquisite multiband imaging data
produced by the Subaru Hyper Suprime-Cam (HSC) Strategic Program survey. The
candidate selection is performed by combining several photometric approaches
including a Bayesian probabilistic algorithm to reject stars and dwarfs. The
spectroscopic identification was carried out with the Gran Telescopio Canarias
and the Subaru Telescope for the first 80 deg2 of the survey footprint. The
success rate of our photometric selection is quite high, approaching 100 % at
the brighter magnitudes (zAB < 23.5 mag). Our selection also recovered all the
known high-z quasars on the HSC images. Among the 15 discovered objects, six
are likely quasars, while the other six with interstellar absorption lines and
in some cases narrow emission lines are likely bright Lyman-break galaxies. The
remaining three objects have weak continua and very strong and narrow Ly alpha
lines, which may be excited by ultraviolet light from both young stars and
quasars. These results indicate that we are starting to see the steep rise of
the luminosity function of z > 6 galaxies, compared with that of quasars, at
magnitudes fainter than M1450 ~ -22 mag or zAB ~24 mag. Follow-up studies of
the discovered objects as well as further survey observations are ongoing.Comment: Published in ApJ (828:26, 2016
Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
クローン性造血の臨床予後への影響を解明 --遺伝子変異とコピー数異常の統合的な知見--. 京都大学プレスリリース. 2021-07-09.Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here, using a combination of targeted sequencing of 23 CH-related genes and array-based CNA detection of blood-derived DNA, we have delineated the landscape of CH-related SNVs/indels and CNAs in 11, 234 individuals without HM from the BioBank Japan cohort, including 672 individuals with subsequent HM development, and studied the effects of these somatic alterations on mortality from HM and cardiovascular disease, as well as on hematological and cardiovascular phenotypes. The total number of both types of CH-related lesions and their clone size positively correlated with blood count abnormalities and mortality from HM. CH-related SNVs/indels and CNAs exhibited statistically significant co-occurrence in the same individuals. In particular, co-occurrence of SNVs/indels and CNAs affecting DNMT3A, TET2, JAK2 and TP53 resulted in biallelic alterations of these genes and was associated with higher HM mortality. Co-occurrence of SNVs/indels and CNAs also modulated risks for cardiovascular mortality. These findings highlight the importance of detecting both SNVs/indels and CNAs in the evaluation of CH
Discovery of the First Low-Luminosity Quasar at z > 7
We report the discovery of a quasar at z = 7.07, which was selected from the
deep multi-band imaging data collected by the Hyper Suprime-Cam (HSC) Subaru
Strategic Program survey. This quasar, HSC J124353.93+010038.5, has an order of
magnitude lower luminosity than do the other known quasars at z > 7. The
rest-frame ultraviolet absolute magnitude is M1450 = -24.13 +/- 0.08 mag and
the bolometric luminosity is Lbol = (1.4 +/- 0.1) x 10^{46} erg/s. Its spectrum
in the optical to near-infrared shows strong emission lines, and shows evidence
for a fast gas outflow, as the C IV line is blueshifted and there is indication
of broad absorption lines. The Mg II-based black hole mass is Mbh = (3.3 +/-
2.0) x 10^8 Msun, thus indicating a moderate mass accretion rate with an
Eddington ratio 0.34 +/- 0.20. It is the first z > 7 quasar with sub-Eddington
accretion, besides being the third most distant quasar, known to date. The
luminosity and black hole mass are comparable to, or even lower than, those
measured for the majority of low-z quasars discovered by the Sloan Digital Sky
Survey, and thus this quasar likely represents a z > 7 counterpart to quasars
commonly observed in the low-z universe.Comment: Accepted for publication in ApJ Letter
First Data Release of the Hyper Suprime-Cam Subaru Strategic Program
The Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) is a three-layered
imaging survey aimed at addressing some of the most outstanding questions in
astronomy today, including the nature of dark matter and dark energy. The
survey has been awarded 300 nights of observing time at the Subaru Telescope
and it started in March 2014. This paper presents the first public data release
of HSC-SSP. This release includes data taken in the first 1.7 years of
observations (61.5 nights) and each of the Wide, Deep, and UltraDeep layers
covers about 108, 26, and 4 square degrees down to depths of i~26.4, ~26.5, and
~27.0 mag, respectively (5sigma for point sources). All the layers are observed
in five broad bands (grizy), and the Deep and UltraDeep layers are observed in
narrow bands as well. We achieve an impressive image quality of 0.6 arcsec in
the i-band in the Wide layer. We show that we achieve 1-2 per cent PSF
photometry (rms) both internally and externally (against Pan-STARRS1), and ~10
mas and 40 mas internal and external astrometric accuracy, respectively. Both
the calibrated images and catalogs are made available to the community through
dedicated user interfaces and database servers. In addition to the pipeline
products, we also provide value-added products such as photometric redshifts
and a collection of public spectroscopic redshifts. Detailed descriptions of
all the data can be found online. The data release website is
https://hsc-release.mtk.nao.ac.jp/.Comment: 34 pages, 20 figures, 7 tables, moderate revision, accepted for
publication in PAS