SYSTEMATIC REVIEW: THE ENHANCEMENT OF ANTI-INFLAMMATION ACTIVITY OF NON STEROIDAL ANTI-INFLAMMATORY DRUG (NSAID) BY SOLID DISPERSION MODIFICATIONS

Objective: NSAIDs are very hydrophobic drugs and have low solubility. This causes the bioavailability of NSAIDs to be low in the body thus affect its anti-inflammatory activity. There has been some primary research proven that solid dispersion can increase the solubility and anti-inflammatory activity of NSAIDs. Moreover, there are not researches explaining the effect of a solid dispersion system on the anti-inflammatory activity of NSAIDs. Therefore, it is necessary to conduct a review to assess the effect of the solid dispersion system on the solubility and anti-inflammatory activity of NSAIDs systematically. Methods: This was systematic review research, where the data were originated from PubMed and Science Direct with the keywords ‘NSAID’, ‘solid dispersion’, and ‘drug effect’. The inclusion criteria formulated were English-language papers, published in 2010–2020, and primary research that conducted in vivo anti-inflammatory testing. The appropriate papers by the inclusion criteria were assessed its quality by the SYRCLE’s tool. Data was analyzed narratively. Results: The results were eight papers under the inclusion criteria. As a whole is known modification of solid dispersion can increase the dissolution profile of NSAIDs. This is because the polymer used can increase the wetting of drug particles, thereby being able to increase the solubility of NSAIDs. Conclusion: The anti-inflammatory activity of NSAIDs by solid dispersion systems are increases compared to NSAIDs without solid dispersions

OPTIMATION OF ETHANOL CONCENTRATION IN EXTRACTION OF EUGENOL FROM GALANGAL RHIZOME

   Objective: The main objective of this study was to determine the optimal ethanol concentration as solvent for extracting eugenol from galangal.Methods: Galangal rhizome extraction was conducted with kinetic maceration at 50°C with various ethanol concentration as solvent (0%, 30%, 50%, 70%, and 96%). A 1:10 ratio of rhizome and ethanol was applied. The extract was obtained, then its eugenol concentration was analyzed qualitatively and quantitatively by thin-layer chromatography-densitometer with n-hexane:ethyl acetate (4:1) by using mobile phase and silica gel 60 F254 as stationary phase and applying a wavelength of 283 nm.Results: The result of qualitative analysis showed that extract of 70% and 96% ethanol had a spot with Rf value 0.63, which was equal to the Rf value of standard eugenol. Standard curve equation for the 70% ethanol extract was y=89318x+656.07 (r=0.9993) and for the 96% ethanol extract was y=8658x+1743 (r=0.9999). The result of the quantitative analysis showed that the 70% and 96% ethanol extract contained 4.85% and 4.79% eugenol, respectively.Conclusion: Extraction of galangal rhizome in 70% and 96% ethanol was positively containing eugenol. Highest eugenol concentration (4.85%) was obtained from galangal rhizome extraction in 70% ethanol

Pemberdayaan Masyarakat melalui Wirausaha Kerupuk Bonggol Pisang di Kabupaten Sukoharjo

One effort that can be done by housewives is entrepreneurship to make crackers. Food products from banana trees were chosen because they have good prospects, besides the fruit there are other parts that can be used, namely banana humps. Because of the benefits and high nutritional content, it is necessary to diversify from banana humps to be sold. The purpose of this activity is to inspire partners about the idea and spirit of entrepreneurship using sources of raw materials that are easy to obtain, so they can increase income. The program is carried out through two stages, namely processing banana humps into healthy crackers and transferring packaging technology. This activity was carried out in the training and development of technology for processing banana humps into cracker products, which could be an alternative economic new business in the community. The positive impact of this activity is the increasing skills and knowledge of partners about making food from banana trees, as well as improving the skills of packaging techniques. There is an increase in the ability of entrepreneurial partners in producing and selling products

The effect of propylene glycol and polyethylene glycol 400 on physicochemical properties of peel off mask of nanosilver using bioreductor Sweet Orange Peels (Citrus sinensis L. Osbeck)

Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids and citric acid, which can be a bioreductor and capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed in a gel for acne treatment through a peel-off mask preparation. Humectants provide moisture, prevent skin irritation and regulate the viscosity of the preparation. Propylene Glycol (PG) and Polyethylene Glycol 400 (PEG 400) are humectants combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of AgNPs and the effect of humectant combinations on the physicochemical properties of peel-off mask preparations. AgNPs characterization was performed using UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The PG-PEG 400 combinations are F1 (0: 100%); F2 (25%: 75%); F3 (50%: 50%); F4 (75%: 25%) and F5 (100%: 0). The physical-chemical test for 28 days included organoleptic, viscosity, dry time, and pH. The biosynthesis results produced AgNPs with maximum absorption of nanoparticles at 435 nm, rod morphological shapes measuring 106 ± 10.6 nm, and PI 0.26 ± 0.06. Statistical analysis showed that the PG-PEG 400 combination significantly affected the viscosity, dispersibility, and dry time of the preparation but affected nothing to pH. The combination of PG-PEG 400 decreased the viscosity and increased the dispersibility of peel-off mask preparation. The higher concentration of propylene glycol caused the dry time of preparation to become longer. Formulas with PG-PEG 400 combination of 25%: 75% and 75%: 25% meet the requirements of viscosity, dispersibility, dry time, and pH and not significant changes during 28 days of storage at room temperature

Innovations Healthy Drinks in Source of Soybean in Community Empowerment through Entrepreneurship in Sukoharjo District

Community service activities with IbM scheme have been done in home industry of soybean milk processing in Sraten and Kartasura Village, Sukoharjo District. The aim of activities are all partners able process soybean juice into health drink product in ready to drink packaging, adn next can be as new economic commodity to the community. In addition, partners are expected to have a clear administrative and governance system in finance, production and, marketing as an effort to empower communities in Sukoharjo District. Considering the benefits of this soy essence is so great then product diversification is needed so that the product is more acceptable to the market. This program is done through several stages namely 1) Making soybeans into ready-to-drink; 2) Transfer of packing technology; 3) Product marketing and management aspects of soybean processing into beverages in ready-to-drink packaging as well as; and 4) Feasibility analysis of beverage production business made from soybean. Through IbM, training and development of soya bean processing technology is made into an economic commodity product in the form of beverages in ready-to-drink packaging, which can provide new economic alternatives in the community. After this program, the community service activity was conducted with the training and mentoring approach to the two partners, it was able to increase the quantity and quality of soybean beverage production where the yield of production increased almost twice from the original

PENGGUNAAN TEPUNG AGAR SEBAGAI PENGIKAT DALAM TABLET ANTIDIABETES EKSTRAK ETANOL BAWANG MERAH

Bawang merah telah terbukti secara empirik dan ilmiah memiliki khasiat sebagai antidiabetes. Diabetes mellitus merupakan penyakit serius dan menjadi salah satu penyebab kematian di berbagai negara berkembang. Dalam perkembangannya telah banyak penelitian mengenai bawang merah sebagai antidiabetes. Tujuan penelitian ini adalah memformulasi sediaan tablet dari ekstrak bawang merah sebagai antidiabetes dengan menggunakan bahan pengikat tepung agar. Tablet ekstrak etanol bawang merah ini dibuat dengan menggunakan metode granulasi basah yang memvariasikan jumlah tepung agar. Hasil penelitian menunjukkan bahwa tablet ekstrak etanol bawang merah dengan bahan pengikat tepung agar yang telah dibuat memenuhi persyaratan fisik sesuai standar farmakope Indonesia dan beberapa literatur standar. Tablet yang dihasilkan berwarna coklat, memenuhi persyaratan ketika dilakukan pemeriksaan fisik meliputi, sifat alir granul, keseragaman ukuran tablet, keseragaman bobot tablet, kekerasan tablet, friabilitas tablet, dan waktu hancur tablet. Berdasarkan hasil analisis statistik ANAVA satu arah dengan derajat kepercayaan 95% menunjukkan bahwa variasi penambahan jumlah tepung agar (0,5%, 1,0%, 1,5%, dan 2,0%) kurang memberikan perbedaan yang bermakna antar formula tablet

The effect of propylene glycol and polyethylene glycol 400 on physicochemical properties of peel off mask of nanosilver using bioreductor Sweet Orange Peels (Citrus sinensis L. Osbeck)

Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids and citric acid, which can be a bioreductor and capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed in a gel for acne treatment through a peel-off mask preparation. Humectants provide moisture, prevent skin irritation and regulate the viscosity of the preparation. Propylene Glycol (PG) and Polyethylene Glycol 400 (PEG 400) are humectants combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of AgNPs and the effect of humectant combinations on the physicochemical properties of peel-off mask preparations. AgNPs characterization was performed using UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The PG-PEG 400 combinations are F1 (0: 100%); F2 (25%: 75%); F3 (50%: 50%); F4 (75%: 25%) and F5 (100%: 0). The physical chemical test for 28 days included organoleptic, viscosity, dry time, and pH. The biosynthesis results produced AgNPs with maximum absorption of nanoparticles at 435 nm, rod morphological shapes measuring 106 ± 10.6 nm, and PI 0.26 ± 0.06. Statistical analysis showed that the PG-PEG 400 combination significantly affected the viscosity, dispersibility, and dry time of the preparation but affected nothing to pH. The combination of PG-PEG 400 decreased the viscosity and increased the dispersibility of peel-off mask preparation. The higher concentration of propylene glycol caused the dry time of preparation to become longer. Formulas with PG-PEG 400 combination of 25%: 75% and 75%: 25% meet the requirements of viscosity, dispersibility, dry time, and pH and not significant changes during 28 days of storage at room temperature

STABILITY AND ANTIBACTERIAL ACTIVITY TEST OF NANOSILVER BIOSYNTHETIC HYDROGEL

Objective: This study aims to formulate nanosliver (AgNPs) biosynthetic hydrogel for topical antibacterial treatment and its stability and antibacterial activity. Methods: The mixture (Silver nitrate solution and Turmeric juice) was stirred at room temperature for 24 h; afterward, it was analyzed using UV-VIS spectrophotometry, particle size analysis, and TEM. The carbopol 940 was selected as a gelling agent with an AgNPs concentration of 5%, 10%, 20%, and 30%. Furthermore, the gel preparation was tested for stability using the cycling test method and antibacterial activity. The antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Results: The nanosilver biosynthetic has a yellow-brown color with the maximum wavelength peak at 433 nm, and a particle size of 157.4-166.7 nm. TEM analysis showed that AgNPs have a round shape, while the antibacterial activity of hydrogel preparations was moderately inhibited. Furthermore, the hydrogel was evaluated for pH, viscosity, dispersibility, and antibacterial activity before-after the cycling test. Formula with 30% AgNPs is chosen formula with pH value of 5.87±0.65; viscosity of 4833.3±2.82 c. Ps; and dispersibility of 5.50±0.15 after cycling test. Conclusion: The high concentration of AgNPs will increase the viscosity, pH, and dispersibility. Formula with 30% AgNPs have the highest antibacterial activity. Furthermore, all hydrogel preparations meet the requirements of Indonesian Standard Product (SNI) No. 06-2588-1992 for good gel stability before and after the cycling test