Two-Particle Angular Correlations in pp and p -Pb Collisions at Energies Available at the CERN Large Hadron Collider From a Multiphase Transport Model

We apply a multi-phase transport (AMPT) model to study two-particle angular correlations in $pp$ collisions at $\sqrt{s}= 7$ TeV. Besides being able to describe the angular correlation functions of meson-meson pairs, a large improvement for the angular correlations of baryon-baryon and antibaryon-antibaryon is achieved. We further find that the AMPT model with new quark coalescence provides an even better description on the anti-correlation feature of baryon-baryon correlations observed in the experiments. We also extend the study to p-Pb collisions at $\sqrt{s}= 5.02$ TeV and obtained similar results. These results help us better understand the particle production mechanism in $pp$ and p-Pb collisions at LHC energies.Comment: 12 pages, 9 figures, submit for publicatio

Mulberry Extracts Alleviate A β

Mulberry, which contained high amounts of anthocyanins, has been used in traditional Chinese medicine. Mulberry fruit extracts (ME) have demonstrated the antioxidant activity and neuroprotection. The study was to investigate the neuroprotective efficacy of ME against β-amyloid 25–35- (Aβ25–35-) induced PC12 cells injury. Cells preincubated with or without ME (200 μg/mL) for 24 h were treated with Aβ25–35 (20 μmol/L) for another 24 h. Cell viability was assessed by MTT, gene expression profiles were examined by cDNA microarrays, and RT-PCR were used to confirm the results of microarray assays. ME pretreatment was found to neutralize the cytotoxicity and prevent Aβ25–35-induced cells injury. Analyses of gene expression profile revealed that genes involving cell adhesion, peptidase activity, cytokine activity, ion binding activity, and angiogenesis regulation were significantly modulated by ME pretreatment. Among those genes, Apaf1, Bace2, and Plcb4 were enriched in the “Alzheimer’s disease-reference pathway” and downregulated after ME intervention. RT-PCR results showed that ME preincubation could significantly inhibit Aβ25–35 increased mRNA levels of these three genes. Overall, ME pretreatment could substantially alleviate PC12 cells injury and downregulate expression of AD-related genes, such as Apaf1, Bace2, and Plcb4. This study has a great nutrigenomics interest and brings new and important light in the field of AD intervention

Photoredox-catalyzed reaction as a powerful tool for rapid natural product Gem -dimethylation modification: discovery of potent anti-cancer agents with improved druggability

Tylophorine has diverse biological activities; however, the stability, solubility, and central nervous system toxicity have severely limited use of tylophorine. The gem -dimethyl group is an organic chemistry functional group that consists of two methyl groups bonded to the same carbon atom. This feature has gained significant attention in medicinal chemistry due to its unique properties and potential applications in drug design. We applied a new photoredox methodology to tylophorine modification, resulting in a series of gem-dimethyl tylophorine analogues. Among the analogues, compound 4b demonstrated promising activity against a wide range of tumor cell lines and exhibited significantly improved drug-like properties, including enhanced solubility and stability. Compound 4b showed an exceptional inhibitory effect (7.8 nM) against a C481S mutation-induced ibrutinib-resistant non-Hodgkin’s lymphoma cell line, as well as primary tumor cell lines obtained from patients. Importantly, compound 4b exhibited significantly reduced anti-proliferative activity against the normal cell line tested, indicating the potential for an enhanced therapeutic window for compound 4b . Based on these early-stage data, we believe that our study provides a solid foundation for the development of new therapeutic agents for potential drug-resistant cancer treatment in the near future

Reliability modeling for competing failure systems with instant-shift hard failure threshold

There are many researches about the modeling for system under multiple dependent competing failure processes (MDCFP) in recent years. Typically speaking, those failure processes are composed by degradation process (soft failure) and random shock process (hard failure). The threshold of hard failure is a fixed value in previous papers which is not compliance with the engineering practices. Threshold means the ability to resist external random shocks which is also shifting with time due to the usage of system. Thus, this paper establishes a model for MDCFP with instant-shift hard threshold. The hard failure threshold changes with time instantaneously and it is also influenced by external shocks. Afterwards, system reliability model is built. The effectiveness of presented model is demonstrated by the reliability analysis of the micro-engine of Sandia National Laboratories. In addition, sensitive analysis is performed for specific parameters.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author