Fair use and file sharing in research and education

This work was inspired by the well-ventilated current problems around the use of digital file sharing technologies and their promotion of infringement of copyright leading to the alleged destruction of entertainment industries. Different legal systems have applied different analyses to such problems, and there is no clear and coherent answer to the question of whether file sharing, especially in the form of peer-to-peer (P2P), is legal. The particular focus of this thesis flows from the realisation that litigation around file sharing has uniformly explored it from the perspective of users downloading entertainment materials such as music and videos. Comparatively little attention has been paid to whether research and educational users have, or should have, rights to use the same digital file sharing technologies to access copyright materials important to their work. If digital file sharing is declared illegal by the courts at the behest of the entertainment industries, then what will happen to research and educational users of these networks?To explore this key problem, this thesis focuses on how fair use doctrine, the most important exception and limitation to copyright, has transferred from the traditional copyright environment into the context of digital file sharing. By undertaking a study of relevant legislation and cases, such as the well known Napster, Grokster and MP3.com, the “who” issue, namely, who is the party entitled to benefit from a fair use defence will be highlighted.Having established that fair use as a defence operates ineffectively in the digital file sharing environment, the thesis then looks at existing alternative or “fared” use models, and particularly the disadvantages of “fared” use system in serving research and educational file sharing. Finally the thesis turns to what is termed the “voluntary model”: a model in which copyright owners make their works available to academic users for free, via an institutional repository, the authors gaining non-pecuniary benefits while the commercial publisher being cut out as a “middleman”. Although future work to develop the details of this approach would be required, the thesis asserts this is a promising way towards ensuring access to copyright works in research and education thus benefiting society, whilst at the same time establishing fair compensation to authors for their efforts

Synchronous dynamic game on system observability considering one or two steps optimality

This paper studies a system security problem in the context of observability based on a two-party non-cooperative asynchronous dynamic game. A system is assumed to be secure if it is not observable. Both the defender and the attacker have means to modify dimension of the unobservable subspace, which is set as the value function. Utilizing tools from geometric control, we construct the best response set under one-step or two-step optimality to minimize or maximize the value function. We find that the best response sets under one-step optimality are not single-valued maps, resulting in a variety of game outcomes. In the dynamic game considering two-step optimality, definition and existence conditions of lock and oscillation game modes are given. Finally, the best response under two-step optimality and the Stackelberg game equilibrium are compared

Characterising the Response to Blueberry Dietary Interventions Aimed at Improving Cognition and Vascular Function

Inter-individual variations exist in response to dietary factors and to the pathophysiologic development of endpoints related to vascular diseases and cognitive impairment. Therefore, the evaluation and characterisation of responses to a dietary intervention targeting vascular and cognitive health is of importance. A series of investigations were set out. Firstly, previous evidence of randomised controlled trials (RCTs) supplementing fruit and targeting vascular and/or cognitive improvement was sought and evaluated by systematic reviews incorporating meta-analyses. Collectively, the reviews have shown that the consumption of berries with dosage ranging from 22 to 45 g powder, 150 to 300 g frozen berry and 100 to 500 ml juice resulted in a 3.68 mmHg reduction on systolic blood pressure and 1.68 mmHg reduction on DBP. A human dietary intervention with 37 participants was performed comparing two forms of blueberry; either whole fresh blueberry (160 g), freeze-dried blueberry powder (20 g) or placebo control (microcrystalline cellulose) in a 1-week single-blinded cross-over RCT in a relatively young outwardly healthy population. There was no significant effect of either blueberry intervention to improve either vascular function or cognition. No significant putative discriminating urinary metabolites between interventions were found using supervised multivariate analysis. The response to the intervention was calculated for each endpoint using percentage change (+ / -%) compared to the baseline. Extensive inter-individual variation was found in vascular health parameters (- 141 % - + 525 %) and cognitive domains (- 114 % - + 96 %) post-interventions, but there was no consistent response following the two interventions between and within participants. Although several discriminatory metabolites were found between responder (RS) and non-responder (NRS) groups it was not possible to identify predictors of response using receiver-operator-curve analysis. To conclude, we did not find a predictive urinary metabolite as a potential biomarker for differentiating between RS and NRS and no consistent individual responses following both blueberry and blueberry powder interventions were found. This is the first blueberry intervention applying quartile division to characterise response in vascular and cognitive endpoints following a specific dietary intervention. The overall approach for defining a metabolic signature of response could be used in the future for tailoring personalised nutritional advice

Effects of chronic consumption of specific fruit (berries, citrus and cherries) on CVD risk factors: a systematic review and meta-analysis of randomised controlled trials.

Purpose: This review aims to compare the magnitude of the effects of chronic consumption of fruits; specifically berries, citrus and cherries on cardiovascular disease (CVD) risk factors. Methods: PubMed, Web of Science, Scopus, and psycARTICLES were searched from inception until January 2020. Forty-five chronic (≥ 1 week) randomised controlled trials assessing CVD risk factors including endothelial (dys)function, blood pressure (BP), blood lipids and inflammatory biomarkers were included. Results: Investigated interventions reported improvements in endothelial function (n = 8), inflammatory biomarkers and lipid status (n = 14), and BP (n = 10). Berries including juice of barberry, cranberry, grape, pomegranate, powder of blueberry, grape, raspberry and freeze-dried strawberry significantly reduced SBP by 3.68 mmHg (95% CI − 6.79 to − 0.58; P = 0.02) and DBP by 1.52 mmHg (95% CI − 2.87 to − 0.18, P = 0.04). In subgroup analysis, these associations were limited to cranberry juice (SBP by 1.52 mmHg [95% CI − 2.97 to − 0.07; P = 0.05], DBP by 1.78 mmHg [95% CI − 3.43 to − 0.12, P = 0.04] and cherry juice (SBP by 3.11 mmHg [95% CI − 4.06 to − 2.15; P = 0.02]). Berries also significantly elevated sVCAM-1 levels by 14.57 ng/mL (85% CI 4.22 to 24.93; P = 0.02). Conclusion: These findings suggest that supplementing cranberry or cherry juice might contribute to an improvement in blood pressure. No other significant improvements were observed for other specified fruits. More research is warranted comparing different classes of fruit and exploring the importance of fruit processing on their cardiovascular-protective effects

Turning Social Capital into Economic Capital: the Sales Effect of Friendship Group Participation in Social Commerce Websites

Friendship groups have been widely adopted in social commerce platforms because of the powerful and pervasive influence of groups on decision making. Despite their widespread use, the sales effects of seller participation in friendship groups (FGP) have received limited research attention. Using a quasi-experimental design with 373,964 products from 8,250 sellers on a leading social commerce platform, we find that FGP increase sellers\u27 product sales performance through the formation of relational and cognitive capital. In addition, we find that seller guarantee, product guarantee and product rating strengthen the sales effect of FGP, while the number of seller followers weakens the sales effect of FGP. Our study contributes to the literature by examining how, why, and when FGP affect sales performance in social commerce. We also provides guidance for sellers and platforms to use friendship groups and group marketing to improve sales performance in social commerce

Transcriptional Modulation of Intestinal Innate Defense/Inflammation Genes by Preterm Infant Microbiota in a Humanized Gnotobiotic Mouse Model

Background and Aims: It is known that postnatal functional maturation of the small intestine is facilitated by microbial colonization of the gut. Preterm infants exhibit defects in gut maturation, weak innate immunity against intestinal infection and increased susceptibility to inflammatory disorders, all of which may be related to the inappropriate microbial colonization of their immature intestines. The earliest microbes to colonize the preterm infant gut encounter a naïve, immature intestine. Thus this earliest microbiota potentially has the greatest opportunity to fundamentally influence intestinal development and immune function. The aim of this study was to characterize the effect of early microbial colonization on global gene expression in the distal small intestine during postnatal gut development.Methods: Gnotobiotic mouse models with experimental colonization by early (prior to two weeks of life) intestinal microbiota from preterm human infants were utilized. Microarray analysis was used to assess global gene expression in the intestinal epithelium.Results and Conclusion: Multiple intestinal genes involved in metabolism, cell cycle regulation, cell-cell or cell-extracellular matrix communication, and immune function are developmental- and intestinal microbiota- regulated. Using a humanized gnotobiotic mouse model, we demonstrate that certain early preterm infant microbiota from prior to 2 weeks of life specifically induce increased NF-κB activation and a phenotype of increased inflammation whereas other preterm microbiota specifically induce decreased NF-κB activation. These fundamental differences correlate with altered clinical outcomes and suggest the existence of optimal early microbial communities to improve health outcomes.</p

Change in neighborhood socioeconomic status and childhood weight status and body composition from birth to adolescence

Background: We aim to assess the associations between the change in neighborhood socioeconomic score (SES) between birth and 6 years and childhood weight status and body composition from 6 to 13 years.Methods: Data for 3909 children from the Generation R Study, a prospective population-based cohort in the Netherlands were analyzed. The change in neighborhood SES between birth and 6 years was defined as static-high, static-middle, static-low, upward, and downward mobility. Child body mass index (BMI), overweight and obesity (OWOB), fat mass index (FMI) and lean mass index (LMI) were measured at age 6, 10, and 13 years. The associations were explored using generalized estimating equations. The effect modification by child sex was examined. Results: In total, 19.5% and 18.1% of children were allocated to the upward mobility and downward mobility neighborhood SES group. The associations between the change in neighborhood SES and child weight status and body composition were moderated by child sex (p &lt; 0.05). Compared to girls in the static-high group, girls in the static-low group had relatively higher BMI-SDS (β, 95% confidence interval (CI): 0.24, 0.09–0.40) and higher risk of OWOB (RR, 95% CI: 1.98, 1.35–2.91), together with higher FMI-SDS (β, 95% CI: 0.27, 0.14–0.41) and LMI-SDS (β, 95% CI: 0.18, 0.03–0.33). The associations in boys were not significant. Conclusions: An increased BMI and fat mass, and higher risk of OWOB from 6 to 13 years were evident in girls living in a low-SES neighborhood or moving downward from a high- to a low-SES neighborhood. Support for children and families from low-SES neighborhoods is warranted.</p