Unbiased and Robust: External Attention-enhanced Graph Contrastive Learning for Cross-domain Sequential Recommendation

Cross-domain sequential recommenders (CSRs) are gaining considerable research attention as they can capture user sequential preference by leveraging side information from multiple domains. However, these works typically follow an ideal setup, i.e., different domains obey similar data distribution, which ignores the bias brought by asymmetric interaction densities (a.k.a. the inter-domain density bias). Besides, the frequently adopted mechanism (e.g., the self-attention network) in sequence encoder only focuses on the interactions within a local view, which overlooks the global correlations between different training batches. To this end, we propose an External Attention-enhanced Graph Contrastive Learning framework, namely EA-GCL. Specifically, to remove the impact of the inter-domain density bias, an auxiliary Self-Supervised Learning (SSL) task is attached to the traditional graph encoder under a multi-task learning manner. To robustly capture users' behavioral patterns, we develop an external attention-based sequence encoder that contains an MLP-based memory-sharing structure. Unlike the self-attention mechanism, such a structure can effectively alleviate the bias interference from the batch-based training scheme. Extensive experiments on two real-world datasets demonstrate that EA-GCL outperforms several state-of-the-art baselines on CSR tasks. The source codes and relevant datasets are available at https://github.com/HoupingY/EA-GCL.Comment: 9 pages, 4 figures, accepted by ICDM 2023 (workshop-GML4Rec

Visitor Capacity Considering Social Distancing in Urban Parks with Agent-Based Modeling

The COVID-19 pandemic has greatly influenced society in the past few years. Park accessibility and social distancing are considered important under the threat of a long-term epidemic. However, measures that can maintain park accessibility and diminish virus spreading synchronously have been seldom studied before, which may threaten public health in all major urban parks globally. This paper proposed a methodology based on an agent-based model to analyze capacities for parks by simulating park visitor behaviors when they all are social distancing. The model was derived from historical visitor data and realistic visitor behaviors in three park settings. Then, park capacities of varied contact conditions, different park policies, and layout adjustments were analyzed. First, congestions caused by social distancing without proper visitor control are found inside all parks. Second, 85 to 3972 square meters per person is predicted as a safe space in different parks. Third, the current results can be easily adjusted according to various concerns regarding infection distance and rate. Finally, it can be inferred that information provisions are more effective than space design adjustments and mandatory measures. The results can guide park managers and those who plan and design park settings. They are also helpful in improving knowledge of the mechanisms behind visitor behaviors. Moreover, these findings can be tested and verified in a variety of public spaces with many other contact-based illnesses

Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism

The selective RNA-binding protein QKI is essential for myelination in the central nervous system (CNS). QKI belongs to the family of signal transduction activators of RNA (STARs), characteristic of binding RNA and signaling molecules, therefore is postulated to regulate RNA homeostasis in response to developmental signals. Here we report that QKI acts downstream of the Src family protein tyrosine kinases (Src-PTKs) during CNS myelination. QKI selectively interacted with the mRNA encoding the myelin basic protein (MBP). Such interaction stabilized MBP mRNA and was required for the rapid accumulation of MBP mRNA during active myelinogenesis. We found that the interaction between QKI and MBP mRNA was negatively regulated by Src-PTK-dependent phosphorylation of QKI. During early myelin development, tyrosine phosphorylation of QKI in the developing myelin drastically declined, presumably leading to enhanced interactions between QKI and MBP mRNA, which was associated with the rapid accumulation of MBP mRNA and accelerated myelin production. Therefore, developmental regulation of Src-PTK-dependent tyrosine phosphorylation of QKI suggests a novel mechanism for accelerating CNS myelinogenesis via regulating mRNA metabolism

Dynamic Association of the Fragile X Mental Retardation Protein as a Messenger Ribonucleoprotein between Microtubules and Polyribosomes

The fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that regulates translation and plays essential roles in synaptic function. FMRP is bound to specific mRNA ligands, actively transported into neuronal processes in a microtubule-dependent manner, and associated with polyribosomes engaged in translation elongation. However, the biochemical relationship between FMRP–microtubule association and FMRP–polyribosome association remains elusive. Here, we report that although the majority of FMRP is incorporated into elongating polyribosomes in the soluble cytoplasm, microtubule-associated FMRP is predominantly retained in translationally dormant, polyribosome-free messenger ribonucleoprotein (mRNP) complexes. Interestingly, FMRP–microtubule association is increased when mRNPs are dynamically released from polyribosomes as a result of inhibiting translation initiation. Furthermore, the I304N mutant FMRP that fails to be incorporated into polyribosomes is associated with microtubules in mRNP particles and transported into neuronal dendrites in a microtubule-dependent, 3,5-dihydroxyphenylglycine-stimulated manner with similar kinetics to that of wild-type FMRP. Hence, polyribosome-free FMRP–mRNP complexes travel on microtubules and wait for activity-dependent translational derepression at the site of function. The dual participation of FMRP in dormant mRNPs and polyribosomes suggests distinct roles of FMRP in dendritic transport and translational regulation, two distinct phases that control local protein production to accommodate synaptic plasticity