1,407 research outputs found

    Gene Therapy Using RNAi

    Get PDF

    Holographic n-partite Information in Hyperscaling Violating Geometry

    Full text link
    The nn-partite information (nI) is formulated as a measure of multi-partite entanglement. Field theory computation revealed that the sign of nI is indefinite for n3n\geq 3, while holographic studies conjectured a sign property that holographic nI is non-negative/non-positive for even/odd nn, with tripartite information (TI, n=3n=3) proved. We investigate the aspects of nI with holographic duality. With a generically static bulk geometry, we give an alternate geometric proof that holographic TI for parallel disjoint boundary strips is non-positive, and illustrate that remarkably for larger nn, the sign is indefinite. In hyperscaling violating geometry, we confirm the conjectured sign property for strips of equal length with equal separation distance, and self-consistently disprove this conjecture for n>3n>3 with general configurations. Therefore, nI in field theories and holography exhibits compatibility except for n=3n=3. We also discuss other properties of holographic nI with analytic computation: the monotonicity, linearity, relation to hyperscaling violating parameters, temperature and UV cutoff effects, and the physical implications. It is doubtful that nI is an effective measure of entanglement considering the indefinite sign, non-monotonicity, and quasi-linearity of its holographic dual. In this respect, we propose constraints on the multi-partite entanglement measures.Comment: 30 pages, 19 figure

    Predictive Inference with Feature Conformal Prediction

    Full text link
    Conformal prediction is a distribution-free technique for establishing valid prediction intervals. Although conventionally people conduct conformal prediction in the output space, this is not the only possibility. In this paper, we propose feature conformal prediction, which extends the scope of conformal prediction to semantic feature spaces by leveraging the inductive bias of deep representation learning. From a theoretical perspective, we demonstrate that feature conformal prediction provably outperforms regular conformal prediction under mild assumptions. Our approach could be combined with not only vanilla conformal prediction, but also other adaptive conformal prediction methods. Apart from experiments on existing predictive inference benchmarks, we also demonstrate the state-of-the-art performance of the proposed methods on large-scale tasks such as ImageNet classification and Cityscapes image segmentation.The code is available at \url{https://github.com/AlvinWen428/FeatureCP}.Comment: Published as a conference paper at ICLR 202

    ZnO/Cu<sub>2</sub>O heterojunction integrated fiber-optic biosensor for remote detection of cysteine

    Get PDF
    Indium tin oxide, semiconductor nanomaterial ZnO, and Cu2O were first loaded on the surface of the optical fiber to form an optical fiber probe. Large-volume macroscopic spatial light is replaced by an optical fiber path, and remote light injection is implemented. Based on the optical fiber probe, a photoelectrochemical biosensor was constructed and remote detection of cysteine was realized. In this tiny device, the optical fiber probe not only acts as a working electrode to react with the analyte but also directs the light exactly where it is needed. Simultaneously, the electrochemical behavior of cysteine on the surface of the working electrode is dominated by diffusion-control, which provides strong support for quantitative detection. Then, under the bias potential of 0 V, the linear range of the fiber-optic-based cysteine biosensor was 0.01∼1 μM, the regression coefficient (R2) value was 0.9943. In spiked synthetic urine, the detection of cysteine was also realized by the integrated biosensor. Moreover, benefiting from the low optical fiber loss, the new structure also possesses a unique remote detection function. This work confirms that photoelectrochemical biosensors can be integrated via optical fibers and retain comparable sensing performance. Based on this property, different materials can also be loaded on the surface of the optical fiber for remote detection of other analytes. It is expected to facilitate the research on fiber-optic-based integrated biosensors and show application prospects in diverse fields such as biochemical analysis and disease diagnosis.</p

    Increasing Ceftriaxone Resistance in Salmonellae, Taiwan

    Get PDF
    In Taiwan, despite a substantial decline of Salmonella enterica serotype Choleraesuis infections, strains resistant to ciprofloxacin and ceftriaxone persist. A self-transferable blaCMY-2-harboring IncI1 plasmid was identified in S. enterica serotypes Choleraesuis, Typhimurium, Agona, and Enteritidis and contributed to the overall increase of ceftriaxone resistance in salmonellae
    corecore