2,548 research outputs found
Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis
Progressive immune dysfunction associated with aging is known as immunosenescence. The age-related deterioration of immune function is accompanied by chronic inflammation and microenvironment changes. Immunosenescence can affect both innate and acquired immunity. Sepsis is a systemic inflammatory response that affects parenchymal organs, such as the respiratory system, cardiovascular system, liver, urinary system, and central nervous system, according to the sequential organ failure assessment (SOFA). The initial immune response is characterized by an excess release of inflammatory factors, followed by persistent immune paralysis. Moreover, immunosenescence was found to complement the severity of the immune disorder following sepsis. Furthermore, the immune characteristics associated with sepsis include lymphocytopenia, thymus degeneration, and immunosuppressive cell proliferation, which are very similar to the characteristics of immunosenescence. Therefore, an in-depth understanding of immunosenescence after sepsis and its subsequent effects on the organs may contribute to the development of promising therapeutic strategies. This paper focuses on the characteristics of immunosenescence after sepsis and rigorously analyzes the possible underlying mechanism of action. Based on several recent studies, we summarized the relationship between immunosenescence and sepsis-related organs. We believe that the association between immunosenescence and parenchymal organs might be able to explain the delayed consequences associated with sepsis
Impurity resonance states in electron-doped high T_c superconductors
Two scenarios, i.e., the anisotropic s-wave pairing (the s-wave scenario) and
the d-wave pairing coexisting with antiferromagnetism (the coexisting scenario)
have been introduced to understand some of seemingly s-wave like behaviors in
electron doped cuprates. We considered the electronic structure in the presence
of a nonmagnetic impurity in the coexistence scenario. We found that even if
the AF order opens a full gap in quasi-particle excitation spectra, the mid-gap
resonant peaks in local density of states (LDoS) around an impurity can still
be observed in the presence of a d-wave pairing gap. The features of the
impurity states in the coexisting phase are markedly different from the pure AF
or pure d-wave pairing phases, showing the unique role of the coexisting AF and
d-wave pairing orders. On the other hand, it is known that in the pure s-wave
case no mid-gap states can be induced by a nonmagnetic impurity. Therefore we
proposed that the response to a nonmagnetic impurity can be used to
differentiate the two scenarios.Comment: 5 pages, two-column revtex4, 5 figures, author list correcte
(S)-(+)-4-(Oxiran-2-ylmethÂoxy)-9H-carbazole
In the title compound, C15H13NO2, all atoms of the carbazole group are coplanar (r.m.s. deviation = 0.005 Å), and the dihedral angle between this plane and C—O—C plane of oxane group is 57.1 (4)°. The crystal packing is stabilized by an N—H⋯O hydrogen bond, resulting in infinite supraÂmolecular chains along [001]
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