High-performance Self-lubricating Ceramic Composites with Laminated-graded Structure

High-performance ceramic composites are potential candidates for the application of wear-resistance components because of their excellent properties. Nevertheless, many problems, such as high friction coefficient of ceramic material and poor mechanical properties of ceramic-matrix self-lubricating composites, limit a wider range of applications of these composites in tribological areas. Therefore, improving high-toughness ceramic-matrix self-lubricating materials for practical applications is significant. This study proposes a new design for ceramic self-lubricating composites to overcome the conflict between their mechanical and tribological properties. Complying with the design principle of bionic and graded composites, two kinds of self-lubricating ceramic composites with laminated-graded structure were prepared, and their mechanical and tribological properties were studied. The results show that this newly developed ceramic composite has achieved satisfactory strength and tribological properties compared with the traditional ceramic self-lubricating composites. The bending strength reached the same level as the properties of general monolithic ceramics. In the temperature range of 25-800 °C, the friction coefficient of composites was less than 0.55, which was about half of that of monolithic ceramics

The linear and nonlinear inverse Compton scattering between microwaves and electrons in a resonant cavity

In a free space, the Sunyaev-Zel'dovich (SZ) effect is a small spectral distortion of the cosmic microwave background (CMB) spectrum caused by inverse Compton scattering of microwave background photons from energetic electrons in the plasma. However, the microwave does not propagate with a plane waveform in a resonant cavity, the inverse Compton scattering process is a little different from that in a free space. By taking the Fourier expansion of the microwave field in the cavity, the coefficients of the first-order and the higher-order terms describe the local-space effect on the linear and nonlinear inverse Compton scattering respectively. With our theoretical results, the linear or nonlinear inverse Compton scattering cross section between microwave photons and electrons has important applications on the energy calibration of the extremely energetic electron beam, the sources of the terahertz waves, the extreme ultra-violet (EUV) waves or the mid-infrared beams.Comment: 8 pages, 5 figure

Stable radiation field positron acceleration in a micro-tube

Nowadays, there is a desperate need for an ultra-acceleration-gradient method for antimatter particles, which holds great significance in exploring the origin of matter, CP violation, astrophysics, and medical physics. Compared to traditional accelerators with low gradients and a limited acceleration region for positrons in laser-driven charge separation fields, we propose an innovative high-gradient positron acceleration mechanism with implementation advantages. Injecting a relativistic electron beam into a dense plasma micro-tube generates a stable and periodic high-intensity mid-infrared radiation (mid-IR) field, reaching tens of GV/m. This field, propagating synchronously with the electron beam, achieves a 1 GeV energy gain for the positron bunch within 140 picoseconds with a minimal energy spread-approximately 1.56% during a stable phase. By utilizing continuous mid-IR, the efficiency of energy transfer from the electron beam to either a single positron bunch or three positron bunches simultaneously could reach up to 20% and 40%, respectively. This acceleration scheme can achieve cascaded acceleration for a single positron bunch and series acceleration for multiple positron bunches in a continuous, stable, and efficient manner.Comment: 22 pages, 5 figure

Aerostructural Optimization of a Transonic Compressor Rotor

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77121/1/AIAA-15397-760.pd

Aberrant Expression of N-Methylpurine-DNA Glycosylase Influences Patient Survival in Malignant Gliomas

Aim. To examine the expression of N-methylpurine-DNA glycosylase (MPG) gene and protein in glioma samples with different WHO grades and its association with patients' survival. Methods. Immunohistochemistry assay, quantitative real-time PCR and Western blot analysis were carried out to investigate the expression of MPG gene and protein in 128 glioma and 10 non-neoplastic brain tissues. Results. MPG gene expression level in glioma tissues was significantly higher than that in non-neoplastic brain tissues (P < 0.001). Immunohistochemistry also showed that MPG protein was over-expressed in glioma tissues, which was consistent with the resutls of Western blot analysis. Additionally, the expression levels of MPG gene and protein both increase from grade I to grade IV glioma according to the results of real-time PCR, immunohistochemistry and western blot analysis. Moreover, the survival rate of MPG-positive patients was significantly lower than that of MPG-negative patients (P < 0.001). We further confirmed that the over-expression of MPG was a significant and independent prognostic indicator in glioma by multivariate analysis (P < 0.001). Conclusions. Our data showed the over-expression of MPG gene and protein in human gliomas, and also suggested for the first time that MPG be an unfavorable independent prognostic indicator for glioma patients

MicroRNA-223 Delivered by Platelet-Derived Microvesicles Promotes Lung Cancer Cell Invasion via Targeting Tumor Suppressor EPB41L3

Background: Patients with hematogenous metastatic lung cancer displayed significantly increased platelet count and aggregation compared to lung cancer patients without hematogenous metastasis. The mechanism underlying the correlation between the lung cancer hematogenous metastasis and platelet activation remains unknown. Results: In the present study, we explored the role of microRNA-223 (miR-223) derived from platelets in modulating lung cancer cell invasion. Our results demonstrated that platelets from NSCLC patients contain higher level of miR-223 than that from healthy subjects. The concentration of miR-223 in the platelet-secreted microvesicles (P-MVs) from NSCLC patients was also increased compared to that from healthy subjects. Incubation of human lung cancer A549 cells with P-MVs resulted in rapid delivery of miR-223 into A549 cells, in which platelet miR-223 targeted EPB41L3 and thus promoted A549 cell invasion. The effect of P-MVs on reducing EPB41L3 in A549 cells but promoting tumor cell invasion could be largely abolished by depletion of miR-223 via transfection with miR-223 antagomir. The role of EPB41L3 in inhibiting A549 cell invasion was further validated by directly downregulating EPB41L3 via transfecting cells with EPB41L3 siRNA or miR-223 mimic. Conclusions: Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3

Case Report: Primary hepatic neuroendocrine tumor: two cases report with literature review

Background &amp; AimsPrimary hepatic neuroendocrine tumors (PHNETs) are rare malignant liver tumors that present diagnostic challenges owing to their rarity and absence of specific clinical features. This study aimed to investigate the characteristics of this rare liver tumor to enhance our understanding of the disease, improve diagnostic accuracy, and explore standardized diagnostic and treatment approaches.Case descriptionDuring physical examination, two elderly women, aged 64 and 74 years, were found to have liver masses. 18F-FDG Positron Emission Tomography-Computed Tomography (18F-FDG PET-CT) and Ga68-DOTATATE PET-CT scans of both individuals revealed multiple liver masses that were initially suspected to be hepatic neuroendocrine tumors. Subsequent puncture pathology confirmed the diagnosis of neuroendocrine tumors. Furthermore, in Case 1, the tumor was also detected by 18F-FDG PET-CT in the lung, suggesting a metastatic tumor, in conjunction with liver immunohistochemistry and imaging findings. Laboratory tests revealed no significant abnormalities in liver function or autoimmune liver disease indicators, and there was no evidence of viral hepatitis infection. However, partial hepatectomy was not indicated for cases with distant metastasis or multiple space-occupying lesions. Individualized treatment approaches have been developed for such situations. A large portion of the tumor underwent Transarterial Embolization (TAE), and targeted combination chemotherapy or endocrine therapy was administered based on the pathological results. During regular follow-ups a 13 and 12 months, the tumor remained stable. The patients’ quality of life was good, and their psychological well-being was healthy. They led active lifestyles, demonstrated a thorough understanding of their disease and its progression, and actively cooperated during the follow-up process.ConclusionOur findings suggest that a combination of serological, radiological, and immunohistochemical examinations can aid in the diagnosis of PHNET. In addition, we determined that TAE combined with drug therapy could be an effective method for controlling PHNET progression. Regular postoperative follow-ups are important for monitoring the prognosis and tumor progression status of patients with PHNET