2,114 research outputs found
Molecular Motors Interacting with Their Own Tracks
Dynamics of molecular motors that move along linear lattices and interact
with them via reversible destruction of specific lattice bonds is investigated
theoretically by analyzing exactly solvable discrete-state ``burnt-bridge''
models. Molecular motors are viewed as diffusing particles that can
asymmetrically break or rebuild periodically distributed weak links when
passing over them. Our explicit calculations of dynamic properties show that
coupling the transport of the unbiased molecular motor with the bridge-burning
mechanism leads to a directed motion that lowers fluctuations and produces a
dynamic transition in the limit of low concentration of weak links. Interaction
between the backward biased molecular motor and the bridge-burning mechanism
yields a complex dynamic behavior. For the reversible dissociation the backward
motion of the molecular motor is slowed down. There is a change in the
direction of the molecular motor's motion for some range of parameters. The
molecular motor also experiences non-monotonic fluctuations due to the action
of two opposing mechanisms: the reduced activity after the burned sites and
locking of large fluctuations. Large spatial fluctuations are observed when two
mechanisms are comparable. The properties of the molecular motor are different
for the irreversible burning of bridges where the velocity and fluctuations are
suppressed for some concentration range, and the dynamic transition is also
observed. Dynamics of the system is discussed in terms of the effective driving
forces and transitions between different diffusional regimes
New and Old Results in Resultant Theory
Resultants are getting increasingly important in modern theoretical physics:
they appear whenever one deals with non-linear (polynomial) equations, with
non-quadratic forms or with non-Gaussian integrals. Being a subject of more
than three-hundred-year research, resultants are of course rather well studied:
a lot of explicit formulas, beautiful properties and intriguing relationships
are known in this field. We present a brief overview of these results,
including both recent and already classical. Emphasis is made on explicit
formulas for resultants, which could be practically useful in a future physics
research.Comment: 50 pages, 15 figure
Transport of Molecular Motor Dimers in Burnt-Bridge Models
Dynamics of molecular motor dimers, consisting of rigidly bound particles
that move along two parallel lattices and interact with underlying molecular
tracks, is investigated theoretically by analyzing discrete-state stochastic
continuous-time burnt-bridge models. In these models the motion of molecular
motors is viewed as a random walk along the lattices with periodically
distributed weak links (bridges). When the particle crosses the weak link it
can be destroyed with a probability , driving the molecular motor motion in
one direction. Dynamic properties and effective generated forces of dimer
molecular motors are calculated exactly as a function of a concentration of
bridges and burning probability and compared with properties of the
monomer motors. It is found that the ratio of the velocities of the dimer and
the monomer can never exceed 2, while the dispersions of the dimer and the
monomer are not very different. The relative effective generated force of the
dimer (as compared to the monomer) also cannot be larger than 2 for most sets
of parameters. However, a very large force can be produced by the dimer in the
special case of for non-zero shift between the lattices. Our
calculations do not show the significant increase in the force generated by
collagenase motor proteins in real biological systems as predicted by previous
computational studies. The observed behavior of dimer molecular motors is
discussed by considering in detail the particle dynamics near burnt bridges.Comment: 21 pages and 11 figure
Dynamic Properties of Molecular Motors in Burnt-Bridge Models
Dynamic properties of molecular motors that fuel their motion by actively
interacting with underlying molecular tracks are studied theoretically via
discrete-state stochastic ``burnt-bridge'' models. The transport of the
particles is viewed as an effective diffusion along one-dimensional lattices
with periodically distributed weak links. When an unbiased random walker passes
the weak link it can be destroyed (``burned'') with probability p, providing a
bias in the motion of the molecular motor. A new theoretical approach that
allows one to calculate exactly all dynamic properties of motor proteins, such
as velocity and dispersion, at general conditions is presented. It is found
that dispersion is a decreasing function of the concentration of bridges, while
the dependence of dispersion on the burning probability is more complex. Our
calculations also show a gap in dispersion for very low concentrations of weak
links which indicates a dynamic phase transition between unbiased and biased
diffusion regimes. Theoretical findings are supported by Monte Carlo computer
simulations.Comment: 14 pages. Submitted to J. Stat. Mec
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