Clinical Guidelines of the Russian Society of Surgeons, the Russian Gastroenterological Association, the Association of Surgeons-Hepatologists and the Endoscopic Society “REndO” on Diagnostics and Treatment of Chronic Pancreatitis

Aim: to present modern methods of diagnosis and treatment of chronic pancreatitis for gastroenterologists, general practitioners and physicians.Chronic pancreatitis (CP) is a long-term inflammatory disease of the pancreas, manifested by irreversible morphological changes in the parenchyma and pancreatic ducts, which cause pain and/or persistent impairment of function. Current concept on the etiology of CP is reflected by the TIGAR-O classification. The criteria for establishing the diagnosis of CP include typical attacks of abdominal pain and/or clinical and laboratory signs of exocrine, endocrine insufficiency with the mandatory detection of characteristic morphological changes (calcifications in the parenchyma and pancreatic ductal stones, dilatation of the main pancreatic duct and its branches). CT, MRCP, and pancreatobiliary endosonography are recommended as the methods of choice to verify the diagnosis of CP. Conservative treatment of patients with CP is provided for symptom relief and prevention of complications. Individual cases with severe non-interactable abdominal pain, as well as a complicated course of the disease (development of ductal hypertension due to main pancreatic duct stones or strictures, obstructive jaundice caused by compression of the common bile duct, symptomatic postnecrotic cysts, portal hypertension due to compression of the portal vein or thrombosis of the splenic vein, persistent duodenal obstruction, pseudoaneurysm of the celiac trunk basin and the superior mesenteric artery) serve as an indication for endoscopic or surgical treatment. The Guidelines set out modern approaches to the diagnosis, conservative, endoscopic and surgical treatment of CP, and the prevention of its complications.Conclusion. The implementation of clinical guidelines can contribute to the timely diagnosis and improve the quality of medical care for patients with chronic pancreatitis

First Russian Gastroenterology Olympiad

On October 21, 22, 23, 2022, within the framework of the 122nd International Session of the National School of Gastroenterology, Hepatology (NSGH) of the Russian Gastroenterological Association (RGA), the First Russian Gastroenterology Olympiad was held

Efficacy of Trimebutine Maleate (Trimedat®) in the Treatment of Patients with Functional Dyspepsia: Results of the “TREND” Observational Study

Aim. This research is aimed at investigating the experience of applying trimebutine maleate in the daily practice of physicians managing patients with functional dyspepsia syndrome (FDS).Materials and methods. The study included 100 patients diagnosed with FDS. The patients were asked to complete a 7 × 7 and SF36 questionnaires before and on the 7th, 14th, 28th days of treatment. The treatment was performed using trimebutine (Trimedat®) in a standard dosage of 200 mg × 3 times a day for 28 days.Results. In the group under study, 45 (45 %), 3 (3 %) and 52 (52 %) patients suffered from epigastric pain syndrome (EPS), postprandial distress syndrome (PPDS) and a combination of both syndromes, respectively. The combination of FDS with gastroesophageal reflux disease (GERD) was noted in 15 patients (15 %). Irritable bowel syndrome (IBS) was present in 21 cases (21 %). Trimebutine maleate (Trimedat®) has been proven effective in all FDS forms, such as EPS, PPDS and their combination. In the course of treatment, the average score of the patients’ physical and mental health increased from 48.02 ± 5.62 to 52.97 ± 4.17 points (p < 0.0001), and from 48.48 ± 10.83 up to 51.79 ± 8.51 points (p < 0.0001), respectively.Conclusion. The main clinical forms of functional dyspepsia syndrome (EPS and PPDS) are frequently manifested in combination either with each other (52 %), or with IBS (21 %) and GERD (15 %). The use of trimebutine in the treatment of patients with FDS is shown to result in a decrease in the severity of its main symptoms and a reliable increase in the quality of patients’ life

Efficacy of Trimebutine Maleate (Trimedat®) in the Treatment of Patients with Functional Dyspepsia: Results of the “TREND” Observational Study

Aim. This research is aimed at investigating the experience of applying trimebutine maleate in the daily practice of physicians managing patients with functional dyspepsia syndrome (FDS).Materials and methods. The study included 100 patients diagnosed with FDS. The patients were asked to complete a 7 × 7 and SF36 questionnaires before and on the 7th, 14th, 28th days of treatment. The treatment was performed using trimebutine (Trimedat®) in a standard dosage of 200 mg × 3 times a day for 28 days.Results. In the group under study, 45 (45 %), 3 (3 %) and 52 (52 %) patients suffered from epigastric pain syndrome (EPS), postprandial distress syndrome (PPDS) and a combination of both syndromes, respectively. The combination of FDS with gastroesophageal reflux disease (GERD) was noted in 15 patients (15 %). Irritable bowel syndrome (IBS) was present in 21 cases (21 %). Trimebutine maleate (Trimedat®) has been proven effective in all FDS forms, such as EPS, PPDS and their combination. In the course of treatment, the average score of the patients’ physical and mental health increased from 48.02 ± 5.62 to 52.97 ± 4.17 points (p < 0.0001), and from 48.48 ± 10.83 up to 51.79 ± 8.51 points (p < 0.0001), respectively.Conclusion. The main clinical forms of functional dyspepsia syndrome (EPS and PPDS) are frequently manifested in combination either with each other (52 %), or with IBS (21 %) and GERD (15 %). The use of trimebutine in the treatment of patients with FDS is shown to result in a decrease in the severity of its main symptoms and a reliable increase in the quality of patients’ life