MATHEMATICAL MODELS PREDICTING LEUKOPENIA AND NEUTROPENIA IN PATIENTS WITH CHRONIC HEPATITIS C IN THE BACKGROUND INTERFERONCONTAINING SCHEMES

Currently in the Russian Federation or chronic hepatitis C (CHC) are still relevant Interferon-based regimens. The purpose of this study is to investigate the influence of baseline characteristics and prognosis of the patient HCV genotype 1 for the development  of leukopenia (LP) and neutropenia  (NP). We investigated  factors such as sex, age, body mass index (BMI), viral load, genotype  of Interleukin-28 B (IL-28B),  the initial level of leukocytes and neutrophils,  alanine aminotransferase (ALT), fibrosis, duration  of infection, presence  of previous therapy.  Absolute values of leukocytes  and neutrophils  were analyzed on 4, 12, 24, 48 weeks of therapy,  and at 4, 12, 24 weeks after antiviral treatment with protease  inhibitors (PI) 1 and 2 generation. Prognostic criteria were identified, indicating the possible development  of the LP and NP expressed during treatment with interferon: female  gender,  low initial load, TT-genotype of IL-28B, the  initial level of white  blood cells and neutrophils  below 5,7×109/L and 3,4×109/L, respectively. Mathematical  models predicting the onset of LP and NP, formalized in the form of decision trees were also constructed. These models have shown the greatest potential for practical use in view of highest accuracy and reliability

MORBIDITY AND MORTALITY FROM MALIGNANT NEOPLASMS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS

In this review we continue the publication of data on the problem of malignant neoplasms (MN) associated with human papillomavirus (HPV), in Russia. In a previous publication (Research’n Practical Medicine Journal 2016; 3(1): 66–78. DOI: 10.17709/2409-2231-2016-3-1-9) we at the first time presented the data on the incidence of malignant tumors associated with HPV in the Russian Federation for the period from 2009 to 2014. This article presents updated data on the incidence of in 2015, as well as data on mortality from the MN associated with HPV in Russia with the analysis of trends in men and women in different age groups. The statistics used in the article is calculated according to the annual state reporting documentation of the statistical form of the Ministry of health No. 7 and No. 35, forms 5 and Rosstat data, the combined database of the state of the cancer register of the Russian Federation

On one-sided estimates for row-finite systems of ordinary differential equations

summary:We prove an existence and uniqueness theorem for row-finite initial value problems. The right-hand side of the differential equation is supposed to satisfy a one-sided matrix Lipschitz condition with a quasimonotone row-finite matrix which has an at most countable spectrum