The \ion{H}{I}-rich Ultra-diffuse Galaxies follow the Extended Schmidt Law

The \ion{H}{I}-rich ultra-diffuse galaxies (HUDGs) offer a unique case for studies of star formation laws (SFLs) as they host low star formation efficiency (SFE) and low-metallicity environments where gas is predominantly atomic. We collect a sample of six HUDGs in the field and investigate their location in the extended Schmidt law($\Sigma_{\text {SFR }} \propto \left(\Sigma_{\text{star}}^{0.5} \Sigma_{\text{gas}}\right)^{1.09}$). They are consistent with this relationship well (with deviations of only 1.1 sigma). Furthermore, we find that HUDGs follow the tight correlation between the hydrostatic pressure in the galaxy mid-plane and the quantity on the x-axis ($\rm log(\Sigma_{star}^{0.5}\Sigma_{gas})$) of the extended Schmidt law. This result indicates that these HUDGs can be self-regulated systems that reach the dynamical and thermal equilibrium. In this framework, the stellar gravity compresses the disk vertically and counteracts the gas pressure in the galaxy mid-plane to regulate the star formation as suggested by some theoretical models.Comment: 6 pages, 4 figures, accepted for publication in MNRA

The Volumetric Extended-Schmidt Law: A Unity Slope

We investigate the extended-Schmidt (ES) law in volume densities ($\rho_{\rm SFR}$ $\propto$ $(\rho_{\rm gas}\rho_{\rm star}^{0.5})^{\alpha^{\rm VES}}$) for spatially-resolved regions in spiral, dwarf, and ultra-diffuse galaxies (UDGs), and compare to the volumetric Kennicutt-Schmidt (KS) law ($\rho_{\rm SFR}$ $\propto$ $\rho_{\rm gas}^{\alpha^{\rm VKS}}$). We first characterize these star formation laws in individual galaxies using a sample of 11 spirals, finding median slopes $\alpha^{\rm VES}$=0.98 and $\alpha^{\rm VKS}$=1.42, with a galaxy-to-galaxy rms fluctuation that is substantially smaller for the volumetric ES law (0.18 vs 0.41). By combining all regions in spirals with those in additional 13 dwarfs and one UDG into one single dataset, it is found that the rms scatter of the volumetric ES law at given x-axis is 0.25 dex, also smaller than that of the volumetric KS law (0.34 dex). At the extremely low gas density regime as offered by the UDG, the volumetric KS law breaks down but the volumetric ES law still holds. On the other hand, as compared to the surface density ES law, the volumetric ES law instead has a slightly larger rms scatter, consistent with the scenario that the ES law has an intrinsic slope of $\alpha^{\rm VES} \equiv$1 but the additional observational error of the scale height increases the uncertainty of the volume density. The unity slope of the ES law implies that the star formation efficiency (=$\rho_{\rm SFR}$/$\rho_{\rm gas}$) is regulated by the quantity that is related to the $\rho_{\rm star}^{0.5}$.Comment: 15 pages, 8 figures, accepted by MNRA

High-resolution chalcogenide fiber bundles for infrared imaging

An ordered chalcogenide fiber bundle with a high resolution for infrared imaging was fabricated using a stack-and-draw approach. The fiber bundle consisted of about 810,000 single fibers with an As2S3 glass core of 9 μm in diameter and a polyetherimide (PEI) polymer cladding of 10 μm in diameter. The As2S3 fibers showed good transparency in the 1.5–6.5 μm spectral region. It presented a resolution of ~45 lp/mm and a crosstalk of ~2.5%. Fine thermal images of a hot soldering iron tip were delivered through the fiber bundle

CT−based radiomics signature for differentiating pyelocaliceal upper urinary tract urothelial carcinoma from infiltrative renal cell carcinoma

ObjectivesTo develop a CT-based radiomics model and a combined model for preoperatively discriminating infiltrative renal cell carcinoma (RCC) and pyelocaliceal upper urinary tract urothelial carcinoma (UTUC), which invades the renal parenchyma.Materials and methodsEighty patients (37 pathologically proven infiltrative RCCs and 43 pathologically proven pyelocaliceal UTUCs) were retrospectively enrolled and randomly divided into a training set (n = 56) and a testing set (n = 24) at a ratio of 7:3. Traditional CT imaging characteristics in the portal venous phase were collected by two radiologists (SPH and ZXL, who have 4 and 30 years of experience in abdominal radiology, respectively). Patient demographics and traditional CT imaging characteristics were used to construct the clinical model. The radiomics score was calculated based on the radiomics features extracted from the portal venous CT images and the random forest (RF) algorithm to construct the radiomics model. The combined model was constructed using the radiomics score and significant clinical factors according to the multivariate logistic regression. The diagnostic efficacy of the models was evaluated using receiver operating characteristic (ROC) curve analysis and the area under the curve (AUC).ResultsThe RF score based on the eight validated features extracted from the portal venous CT images was used to build the radiomics model. Painless hematuria as an independent risk factor was used to build the clinical model. The combined model was constructed using the RF score and the selected clinical factor. Both the radiomics model and combined model showed higher efficacy in differentiating infiltrative RCC and pyelocaliceal UTUC in the training and testing cohorts with AUC values of 0.95 and 0.90, respectively, for the radiomics model and 0.99 and 0.90, respectively, for the combined model. The decision curves of the combined model as well as the radiomics model indicated an overall net benefit over the clinical model. Both the radiomics model and the combined model achieved a notable reduction in false-positive and false-negativerates, resulting in significantly higher accuracy compared to the visual assessments in both the training and testing cohorts.ConclusionThe radiomics model and combined model had the potential to accurately differentiate infiltrative RCC and pyelocaliceal UTUC, which invades the renal parenchyma, and provide a new potentially non-invasive method to guide surgery strategies

Leakage current simulations of Low Gain Avalanche Diode with improved Radiation Damage Modeling

We report precise TCAD simulations of IHEP-IME-v1 Low Gain Avalanche Diode (LGAD) calibrated by secondary ion mass spectroscopy (SIMS). Our setup allows us to evaluate the leakage current, capacitance, and breakdown voltage of LGAD, which agree with measurements' results before irradiation. And we propose an improved LGAD Radiation Damage Model (LRDM) which combines local acceptor removal with global deep energy levels. The LRDM is applied to the IHEP-IME-v1 LGAD and able to predict the leakage current well at -30 $^{\circ}$C after an irradiation fluence of $\Phi_{eq}=2.5 \times 10^{15} ~n_{eq}/cm^{2}$. The charge collection efficiency (CCE) is under development

A Role for a Dioxygenase in Auxin Metabolism and Reproductive Development in Rice

SummaryIndole-3-acetic acid (IAA), the natural auxin in plants, regulates many aspects of plant growth and development. Extensive analyses have elucidated the components of auxin biosynthesis, transport, and signaling, but the physiological roles and molecular mechanisms of auxin degradation remain elusive. Here, we demonstrate that the dioxygenase for auxin oxidation (DAO) gene, encoding a putative 2-oxoglutarate-dependent-Fe (II) dioxygenase, is essential for anther dehiscence, pollen fertility, and seed initiation in rice. Rice mutant lines lacking a functional DAO display increased levels of free IAA in anthers and ovaries. Furthermore, exogenous application of IAA or overexpression of the auxin biosynthesis gene OsYUCCA1 phenocopies the dao mutants. We show that recombinant DAO converts the active IAA into biologically inactive 2-oxoindole-3-acetic acid (OxIAA) in vitro. Collectively, these data support a key role of DAO in auxin catabolism and maintenance of auxin homeostasis central to plant reproductive development

Photoredox-catalyzed reaction as a powerful tool for rapid natural product Gem -dimethylation modification: discovery of potent anti-cancer agents with improved druggability

Tylophorine has diverse biological activities; however, the stability, solubility, and central nervous system toxicity have severely limited use of tylophorine. The gem -dimethyl group is an organic chemistry functional group that consists of two methyl groups bonded to the same carbon atom. This feature has gained significant attention in medicinal chemistry due to its unique properties and potential applications in drug design. We applied a new photoredox methodology to tylophorine modification, resulting in a series of gem-dimethyl tylophorine analogues. Among the analogues, compound 4b demonstrated promising activity against a wide range of tumor cell lines and exhibited significantly improved drug-like properties, including enhanced solubility and stability. Compound 4b showed an exceptional inhibitory effect (7.8 nM) against a C481S mutation-induced ibrutinib-resistant non-Hodgkin’s lymphoma cell line, as well as primary tumor cell lines obtained from patients. Importantly, compound 4b exhibited significantly reduced anti-proliferative activity against the normal cell line tested, indicating the potential for an enhanced therapeutic window for compound 4b . Based on these early-stage data, we believe that our study provides a solid foundation for the development of new therapeutic agents for potential drug-resistant cancer treatment in the near future