Clue-based Spatio-textual Query

Along with the proliferation of online digital map and location-based service, very large POI (point of interest) databases have been constructed where a record corresponds to a POI with information including name, category, address, geographical location and other features. A basic spatial query in POI database is POI retrieval. In many scenarios, a user cannot provide enough information to pinpoint the POI except some clue. For example, a user wants to identify a caf é in a city visited many years ago. SHe cannot remember the name and address but she still recalls that "the caf é is about 200 meters away from a restaurant; and turning left at the restaurant there is a bakery 500 meters away, etc.". Intuitively, the clue, even partial and approximate, describes the spatio-textual context around the targeted POI. Motivated by this observation, this work investigates clue-based spatio-textual query which allows user providing clue, i.e., some nearby POIs and the spatial relationships between them, in POI retrieval. The objective is to retrieve k POIs from a POI database with the highest spatio-textual context similarities against the clue. This work has deliberately designed data-quality-tolerant spatio-textual context similarity metric to cope with various data quality problems in both the clue and the POI database. Through crossing valuation, the query accuracy is further enhanced by ensemble method. Also, this work has developed an index called roll-out-star R-tree (RSR-tree) to dramatically improve the query processing efficiency. The extensive tests on data sets from the real world have verified the superiority of our methods in all aspects. </jats:p

Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer

A wide range of the epigenetic effectors that regulate chromatin modification, gene expression, genomic stability, and DNA repair contain structurally conserved domains called plant homeodomain (PHD) fingers. Alternations of several PHD finger-containing proteins (PHFs) due to genomic amplification, mutations, deletions, and translocations have been linked directly to various types of cancer. However, little is known about the genomic landscape and the clinical significance of PHFs in breast cancer. Hence, we performed a large-scale genomic and transcriptomic analysis of 98 PHF genes in breast cancer using TCGA and METABRIC datasets and correlated the recurrent alterations with clinicopathological features and survival of patients. Different subtypes of breast cancer had different patterns of copy number and expression for each PHF. We identified a subset of PHF genes that was recurrently altered with high prevalence, including PYGO2 (pygopus family PHD finger 2), ZMYND8 (zinc finger, MYND-type containing 8), ASXL1 (additional sex combs like 1) and CHD3 (chromodomain helicase DNA binding protein 3). Copy number increase and overexpression of ZMYND8 were more prevalent in Luminal B subtypes and were significantly associated with shorter survival of breast cancer patients. ZMYND8 was also involved in a positive feedback circuit of the estrogen receptor (ER) pathway, and the expression of ZMYND8 was repressed by the bromodomain and extra terminal (BET) inhibitor in breast cancer. Our findings suggest a promising avenue for future research—to focus on a subset of PHFs to better understand the molecular mechanisms and to identify therapeutic targets in breast cancer

Applied Research of Cleaner Production Evaluation System in Wig Industry

An assessment indicator system of cleaner production in wig industry was built in this article, which intended to meet the shortage of corresponding standards of cleaner production evaluation in the national wig industry. An assessment route of cleaner production index system of the wig industry was established. Based on analysis of the production process and pollution node of the wig industry, the cleaner production index system of wig industry was established for the first time, which contained 6 first-level indicators and 22 second-level indicators. The evaluation indicator baselines were set out in accordance with the cleaner production standards and index systems in other areas when the actual data of each index of the wig enterprises was analyzed statistically. Then, the importance of every index was confirmed by analytic hierarchy process (AHP) and an AHP-Fuzzy comprehensive evaluation model was introduced by utilizing the fuzzy mathematics method. What is more, in order to test and verify the accuracy of the evaluation system, this evaluation system was applied to estimate the cleaner production level of a wig enterprise in Henan province. It was found that the advanced level of this wig company should be 0.1352, as against the membership of the general level was 0.0391, which could be compared to the basic level of 0.0298. The result is consistent with the actual situation of the enterprise, which proves that the system is feasible and can be used to tap the cleaner production potential of wig enterprises and promote the sustainable development of the wig enterprises

HAdV-2-suppressed growth of SV40 T antigen-transformed mouse mammary epithelial cell-induced tumours in SCID mice

AbstractHuman adenovirus (HAdV) vectors are promising tools for cancer therapy, but the shortage of efficient animal models for productive HAdV infections has restricted the evaluation of systemic effects to mainly immunodeficient mice. Previously, we reported a highly efficient replication of HAdV-2 in a non-tumorigenic mouse mammary epithelial cell line, NMuMG. Here we show that HAdV-2 gene expression and progeny formation in NMuMG cells transformed with the SV40 T antigen (NMuMG-T cells) were as efficient as in the parental NMuMG cells. Injection of HAdV-2 into tumours established by NMuMG-T in SCID mice caused reduced tumour growth and signs of intratumoural lesions. HAdV-2 replicated within the NMuMG-T-established tumours, but not in interspersed host-derived tissues within the tumours. The specific infection of NMuMG-T-derived tumours was verified by the lack of viral DNA in kidney, lung or spleen although low levels of viral DNA was occasionally found in liver

A Highly Selective Colorimetric Sensor for Cysteine in Water Solution and Bovine Serum Albumin

A simple colorimetric sensor, 2-bromonaphthalene-1,4-dione, has been developed for the Cysteine detection. The sensor showed its best performance in a mixture of ethanol and HEPES (5 : 5, v/v) solution at pH of 7.0. The results of UV-vis and fluorescence indicated that 2-bromonaphthalene-1,4-dione was selective and sensitive for Cysteine detection without the interference of other amino acids (Cysteine, Alanine, Arginine, Aspartinie, Glutamine, Glycine, Histidine, Isoleucine, Leucine, Lysine, Methionine, Proline, Serine, Threonine, Phenylalanine, Valine, Tryptophan, and Hydroxyproline). 2-Bromonaphthalene-1,4-dione also showed binding ability for Cysteine in bovine serum albumin and could be used as a potential colorimetric sensor among eighteen kinds of natural amino acids. Importantly, the recognition of CySH could be observed by naked eye

Trends in research on dietary behavior and cardiovascular disease from 2002 to 2022: a bibliometric analysis

BackgroundDietary behaviors and cardiovascular disease are two major health issues that have attracted a lot of attention from researchers worldwide. In this study, we aimed to provide a comprehensive analysis of the publication trends, authorship patterns, institutional affiliations, country/region contributions, journal outlets, highly cited documents, and keyword clusters in the field of dietary behaviors and cardiovascular disease research over the past two decades.MethodsWe conducted a systematic literature review of peer-reviewed articles published from 2002 to 2022 in the Web of Science Core Collection database. We extracted and analyzed data on the annual publication volume, authorship patterns, institutional affiliations, country/region contributions, journal outlets, highly cited documents, and keyword clusters using bibliometric methods and visualization tools.ResultsOur study analyzed 3,904 articles, including 702 reviews and 3,202 research articles. The results revealed a continuous increase in the number of publications in this field over the past two decades. The top 10 authors, institutions, and countries/regions with the highest publication output were identified, indicating the leading contributors to this field. Moreover, the most frequently cited documents and highly clustered keywords were identified, providing insights into the research themes and topics in this field.ConclusionOur study provides a comprehensive analysis of the publication trends, authorship patterns, institutional affiliations, country/region contributions, journal outlets, highly cited documents, and keyword clusters in the field of dietary behaviors and cardiovascular disease research over the past two decades. The findings provide valuable information for researchers, policymakers, and stakeholders to understand the research landscape, identify research gaps, and develop future research directions in this field

In Situ Investigation of the Silicon Carbide Particles Sintering

A real-time observation of the microstructure evolution of irregularly shaped silicon carbide powders during solid state sintering is realized by using synchrotron radiation computerized topography (SR-CT) technique. The process of sintering neck growth and material migration during sintering are clearly distinguished from 2D and 3D reconstructed images. The sintering neck size of the sample is presented for quantitative analysis of the sintering kinetics during solid state sintering. The neck size-time curve is obtained. Compared with traditional sintering theories, the neck growth exponent (7.87) obtained by SR-CT experiment is larger than that of the two-sphere model. Such condition is discussed and shown in terms of sintering neck growth, in which the sintering process slows down when the particle shape is irregular rather than spherical