A new approach to the study on counterexamples of generic sentences: From the perspective of interactive reference point-target relationship and re-categorization model

Based on deficiencies of existing researches, this paper, aiming at taking the tolerance of counterexamples reflecting seeming syntax-semantic mismatch in generic sentences, and the online cognitive process of these sentences into the same analyzing framework, proposes the Interactive Reference Point-target Relationship and Re-categorization Model (IRPR-RC Model) to give a unified explanation to the main types of counterexample-tolerating generic sentences (GS), thus further fulfilling the generalization commitment of cognitive linguistics. According to this model: 1) there is an interaction relationship between reference points and targets connecting generic words and attribute words in counterexample-tolerating generic sentences (GS); 2) this interactive relationship provides the premise for re-categorization, which selects a particular sub-category and makes it salient. This process can also be viewed as a phenomenon of attribute words coercing the generic words; 3) the model can be divided into three types: Focusing Type, Imbedding Type and Repulsing Type, according to different operation mechanism of IRPR-RC Model in counterexample-tolerating generic sentences (GS)

NANO-FE AND MWCNTS BASED NON-ENZYMATIC SENSOR FOR DETERMINATION OF GLUCOSE IN SERUUM

The enzyme sensors based on glucose oxidase have been widely used for the detection of blood glucose. However, the activity of enzyme can be easily affected by temperature, pH, humidity and toxic chemical. Nanostructured metal-oxides have been extensively explored to develop nonenzymatic glucose sensors. An amperometric electrode based on multiwall carbon nanotubes (MWCNTs) and Fe nanoparticles has been successfully fabricated. The electrode exhibits the linear regression equation is: I = -0.1985 + 1.7499 CG (correlation coefficient is 0.9994). Linear response range: 0.2-20.0 mM, sensitivity: 1.75 a/am, the LOD was evaluated to be 0.03 mM according to IUPAC regulations (S/N = 3). Interference tests illustrated that 0.2 me of ascorbic acid and uric acid didn't have effect on the determination of glucose. In the presence of 0.02 M chloride ion, the current signal of 0.2 mM glucose almost keeps unchanged at the sensor, revealing that this new sensor has high tolerance level to chloride ion. The sensor has been successfully applied to determine glucose in the serum samples and obtained consist results with conventional spectrometry

Feature-Enhanced Network with Hybrid Debiasing Strategies for Unbiased Learning to Rank

Unbiased learning to rank (ULTR) aims to mitigate various biases existing in user clicks, such as position bias, trust bias, presentation bias, and learn an effective ranker. In this paper, we introduce our winning approach for the "Unbiased Learning to Rank" task in WSDM Cup 2023. We find that the provided data is severely biased so neural models trained directly with the top 10 results with click information are unsatisfactory. So we extract multiple heuristic-based features for multi-fields of the results, adjust the click labels, add true negatives, and re-weight the samples during model training. Since the propensities learned by existing ULTR methods are not decreasing w.r.t. positions, we also calibrate the propensities according to the click ratios and ensemble the models trained in two different ways. Our method won the 3rd prize with a DCG@10 score of 9.80, which is 1.1% worse than the 2nd and 25.3% higher than the 4th.Comment: 5 pages, 1 figure, WSDM Cup 202

Mesoporous crystalline Ti1-xSnxO2 (0 < x < 1) solid solution for a high-performance photocatalyst under visible light irradiation

We report a facile and effective inorganic polycondensation combined with aerosol-spray strategy towards high-performance photocatalyst by fabricating mesoporous Ti1-xSnxO2 (0 &lt; x &lt; 1) solid solution. Such Ti1-xSnxO2 nanocrystals with high Sn-doped contents are self-assembled into mesoporous spheres can effectively promote visible-light harvest and high quantum yield, leading a longer lifetime of the photoelectron-hole pairs and less recombination. Such the photocatalysts enhanced photocatalytic activity for the degradation of Rhodamine B (RhB). The representative Ti0.9Sn0.1O2 and Ti0.8Sn0.2O2 compounds reach an optimum degradation of ≈50% and 70%, respectively, after 120 min irradiation under visible irradiation. The mesoporous Ti1-xSnxO2 solid solution could inhibit the recombination of electron-hole pairs, which promote reaction thermodynamics and kinetics for RhB degradation

Effects of Aromatic Ammoniums on Methyl Ammonium Lead Iodide Hybrid Perovskite Materials

The introduction of bulky ammoniums into methyl ammonium lead iodide hybrid perovskites (MAPbI3) has emerged as a promising strategy to improve the properties of these materials. In the present work, we studied the effects of several aromatic ammoniums onto the structural, electronic, and optical properties of MAPbI3. Although powder XRD data suggest that the bulky cations are not involved in the bulk phase of the MAPbI3, a surprisingly large effect of the bulky cations onto the photoluminescence properties was observed

The role of antibodies in the pathogenesis of multiple sclerosis

The presence of persistent intrathecal oligoclonal immunoglobulin G (IgG) bands (OCBs) and lesional IgG deposition are seminal features of multiple sclerosis (MS) disease pathology. Despite extensive investigations, the role of antibodies, the products of mature CD19+ B cells, in disease development is still controversial and under significant debate. Recent success of B cell depletion therapies has revealed that CD20+ B cells contribute to MS pathogenesis via both antigen-presentation and T-cell-regulation. However, the limited efficacy of CD20+ B cell depletion therapies for the treatment of progressive MS indicates that additional mechanisms are involved. In this review, we present findings suggesting a potential pathological role for increased intrathecal IgGs, the relation of circulating antibodies to intrathecal IgGs, and the selective elevation of IgG1 and IgG3 subclasses in MS. We propose a working hypothesis that circulating B cells and antibodies contribute significantly to intrathecal IgGs, thereby exerting primary and pathogenic effects in MS development. Increased levels of IgG1 and IgG3 antibodies induce potent antibody-mediated cytotoxicity to central nervous system (CNS) cells and/or reduce the threshold required for antigen-driven antibody clustering leading to optimal activation of immune responses. Direct proof of the pathogenic roles of antibodies in MS may provide opportunities for novel blood biomarker identification as well as strategies for the development of effective therapeutic interventions

Epidemiologic study of myelodysplastic syndromes in a multiethnic, inner city cohort

Little is known about the epidemiology of MDS in minority populations. The IPSS and newly released IPSS-R are important clinical tools in prognostication of patients with MDS. Therefore, we conducted a retrospective epidemiological analysis of MDS in an ethnically diverse cohort of patients. Demographics, disease characteristics, and survival were determined in 161 patients seen at Montefiore Medical Center from 1997 to 2011. We observed that Hispanics presented at a younger age than blacks and whites (68 vs. 73.7 vs. 75.6 years); this difference was significant (p = 0.01). A trend towards greater prevalence of thrombocytopenia in Hispanics was observed, but this was not significant (p = 0.08). No other differences between the groups were observed. Overall median survival after diagnosis was the highest among Hispanics (8.6 years) followed by blacks (6.2 years) and Caucasians (3.7). Adjusted hazard ratios however did not show significant differences in risk of death between the groups. The IPSS-R showed slightly better discrimination when compared to the IPSS in this cohort (Somers Dxy 0.39 vs. 0.35, respectively) but observed survival more was more closely approximated by IPSS than by IPSS-R. Our study highlights the possibility of ethnic differences in the presentation of MDS and raises questions regarding which prognostic system is more predictive in this population

H2AX Deficiency is Associated with Erythroid Dysplasia and Compromised Haematopoietic Stem Cell Function

Myelodysplastic syndromes (MDS) are clonal disorders of haematopoiesis characterised by dysplastic changes of major myeloid cell lines. However, the mechanisms underlying these dysplastic changes are poorly understood. Here, we used a genetically modified mouse model and human patient data to examine the physiological roles of H2AX in haematopoiesis and how the loss of H2AX contributes to dyserythropoiesis in MDS. H2AX knockout mice showed cell-autonomous anaemia and erythroid dysplasia, mimicking dyserythropoiesis in MDS. Also, dyserythropoiesis was increased in MDS patients with the deletion of chromosome 11q23, where H2AX is located. Although loss of H2AX did not affect the early stage of terminal erythropoiesis, enucleation was decreased. H2AX deficiency also led to the loss of quiescence of hematopoietic stem and progenitor cells, which dramatically compromised their bone marrow engraftment. These results reveal important roles of H2AX in late-stage terminal erythropoiesis and hematopoietic stem cell function