4,621 research outputs found
MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction Network
Since organism development and many critical cell biology processes are organized in modular patterns, many algorithms have been proposed to detect modules. In this study, a new method, MOfinder, was developed to detect overlapping modules in a protein-protein interaction (PPI) network. We demonstrate that our method is more accurate than other 5 methods. Then, we applied MOfinder to yeast and human PPI network and explored the overlapping information. Using the overlapping modules of human PPI network, we constructed the module-module communication network. Functional annotation showed that the immune-related and cancer-related proteins were always together and present in the same modules, which offer some clues for immune therapy for cancer. Our study around overlapping modules suggests a new perspective on the analysis of PPI network and improves our understanding of disease
Numerical simulation of material flow during FSW to predict defect generation based on non-uniform toolâmaterial contact condition
DiaquaÂbis(N,Nâ˛-dibenzylÂethane-1,2-diamine-Îş2 N,Nâ˛)nickel(II) dichloride N,N-dimethylÂformamide solvate
The asymmetric unit of the title complex, [Ni(C16H20N2)2(H2O)2]Cl2¡C3H7NO, consists of two NiII atoms, each lying on an inversion center, two Cl anions, two N,Nâ˛-dibenzylÂethane-1,2-diamine ligands, two coordinated water molÂecules and one N,N-dimethylÂformamide solvent molÂecule. Each NiII atom is six-coordinated in a distorted octaÂhedral coordination geometry, with the equatorial plane formed by four N atoms and the axial positions occupied by two water molÂecules. The complex molÂecules are linked into a chain along [001] by NâHâŻCl, NâHâŻO and OâHâŻCl hydrogen bonds. The C atoms and H atoms of the solvent molÂecule are disordered over two sites in a ratio of 0.52â
(2):0.48â
(2)
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