Phonetic patterns of Koreans producing English vowels, /i, I, u, U/, in words and in sustained phonation

Ten native-Korean male speakers and ten native-American-English male speakers produced the target vowels /i,I,u,U/ in both words and sustained phonation. These recorded speech samples were judged by a panel of three expert judges for vowel identification. They also were analyzed by the experimenter to determine the formant fi-equencies (F1 and F2) and the vowel duration. All measurements had a high degree of reliability. Korean speakers produced the phonemic vowels, /i/ and /u/ with a high accuracy similar to that of native English speakers. Korean speakers produced the non-phonemic vowels, /I/ and /U/ with very low accuracy (high number of errors); these errors were not observed in the Americans. Korean errors for non-phonemic /I/ and /U/ were predictable errors, i.e., /i/ for /I/, and /u/ for /U/. In addition, Korean speakers had more errors for sustained vowel phonation than words. The first formant (F1) was a better predictor for both the Koreans\u27 phonemic and non-phonemic vowel identification. The second formant (F2) and vowel duration were inconsistent predictors of vowel identification. The Korean phonetic patterns provided information for ESL teaching strategies

Real-time 3-D Mapping with Estimating Acoustic Materials

This paper proposes a real-time system integrating an acoustic material estimation from visual appearance and an on-the-fly mapping in the 3-dimension. The proposed method estimates the acoustic materials of surroundings in indoor scenes and incorporates them to a 3-D occupancy map, as a robot moves around the environment. To estimate the acoustic material from the visual cue, we apply the state-of-the-art semantic segmentation CNN network based on the assumption that the visual appearance and the acoustic materials have a strong association. Furthermore, we introduce an update policy to handle the material estimations during the online mapping process. As a result, our environment map with acoustic material can be used for sound-related robotics applications, such as sound source localization taking into account various acoustic propagation (e.g., reflection)

The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen

SIGN-R1, a recently discovered C-type lectin expressed at high levels on macrophages within the marginal zone of the spleen, mediates the uptake of dextran polysaccharides by these phagocytes. We now find that encapsulated Streptococcus pneumoniae are rapidly cleared by these macrophages from the bloodstream, and that capture also takes place when different cell lines express SIGN-R1 after transfection. To assess the role of the capsular polysaccharide of S. pneumoniae(CPS) in the interaction of SIGN-R1 with pneumococci, we first studied binding and uptake of serotype 14 CPS in transfected cells. Binding was observed and was of a much higher avidity (3,000-fold) for CPS 14 than dextran. The CPSs from four different serotypes were also cleared by marginal zone macrophages in vivo. To establish a role for SIGN-R1 in this uptake, we selectively down-regulated expression of the lectin by pretreatment of the mice with SIGN-R1 antibodies, including a newly generated hamster monoclonal called 22D1. For several days after this transient knockout, the marginal zone macrophages were unable to take up either CPSs or dextrans. Therefore, marginal zone macrophages in mice have a receptor that interacts with capsular pneumococcal polysaccharides, setting the stage for further studies of the functional consequences of this interaction

Odor habituation can modulate very early olfactory event-related potential

Odor habituation is a phenomenon that after repeated exposure to an odor, is characterized by decreased responses to it. The central nervous system is involved in odor habituation. To study odor habituation in humans, measurement of event-related potentials (ERPs) has been widely used in the olfactory system and other sensory systems, because of their high temporal resolution. Most previous odor habituation studies have measured the olfactory ERPs of (200–800) ms. However, several studies have shown that the odor signal is processed in the central nervous system earlier than at 200 ms. For these reasons, we studied whether when odors were habituated, olfactory ERP within 200 ms of odors could change. To this end, we performed an odor habituation behavior test and electroencephalogram experiments. In the behavior test, under habituation conditions, odor intensity was significantly decreased. We found significant differences in the negative and positive potentials within 200 ms across the conditions, which correlated significantly with the results of the behavior test. We also observed that ERP latency depended on the conditions. Our study suggests that odor habituation can involve the olfactory ERP of odors within 200 ms in the brain. © 2020, The Author(s).1

Measuring patient acuity and nursing care needs in South Korea: application of a new patient classification system

Background An accurate and reliable patient classification system (PCS) can help inform decisions regarding adequate assignments for nurse staffing. This study aimed to evaluate the criterion validity of the Asan Patient Classification System (APCS), a new tertiary hospital-specific PCS, by comparing its rating and total scores with those of KPCS-1 and KPCS-GW for measuring patient activity and nursing needs. Methods We performed a retrospective analysis of the medical records of 50,314 inpatients admitted to the general wards of a tertiary teaching hospital in Seoul, South Korea in March, June, September, and December 2019. Spearman’s correlation and Kappa statistics according to quartiles were calculated to examine the criterion validity of the APCS compared with the KPCS-1 and KPCS-GW. Results The average patient classification score was 28.3 points for APCS, 25.7 points for KPCS-1, and 21.6 points for KPCS-GW. The kappa value between APCS and KPCS-1 was 0.91 (95% CI:0.9072, 0.9119) and that between APCS and KPCS-GW was 0.88 (95% CI:0.8757, 0.8810). Additionally, Spearman's correlation coefficients among APCS, KPCS-1, and KPCS-GW showed a very strong correlation. However, 10.8% of the participants’ results were inconsistent, and KPCS-1 tended to classify patients into groups with lower nursing needs compared to APCS. Conclusion This study showed that electronic health record-generated APCS can provide useful information on patients’ severity and nursing activities to measure workload estimation. Additional research is needed to develop and implement a real-world EHR-based PCS system to accommodate for direct and indirect nursing care while considering diverse population and dynamic healthcare system

Tuning Multipolar Mie Scattering of Particles on a Dielectric-Covered Mirror

Optically resonant particles are key building blocks of many nanophotonic devices such as optical antennas and metasurfaces. Because the functionalities of such devices are largely determined by the optical properties of individual resonators, extending the attainable responses from a given particle is highly desirable. Practically, this is usually achieved by introducing an asymmetric dielectric environment. However, commonly used simple substrates have limited influences on the optical properties of the particles atop. Here, we show that the multipolar scattering of silicon microspheres can be effectively modified by placing the particles on a dielectric-covered mirror, which tunes the coupling between the Mie resonances of microspheres and the standing waves and waveguide modes in the dielectric spacer. This tunability allows selective excitation, enhancement, and suppression of the multipolar resonances and enables scattering at extended wavelengths, providing new opportunities in controlling light-matter interactions for various applications. We further demonstrate with experiments the detection of molecular fingerprints by single-particle mid-infrared spectroscopy, and, with simulations strong optical repulsive forces that could elevate the particles from a substrate.Comment: 16 pages, 4 figure