24 research outputs found

    Medical Trends in South Korea

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    Nickel bioaccumulation and the antioxidant response in Pacific abalone Haliotis discus hannai, Ino 1953 exposed to waterborne nickel during thermal stress

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    Pacific abalone, Haliotis discus hannai (mean length 2.92 ± 0.5 cm, and mean weight 2.63 ± 0.4 g) were exposed to different concentrations of waterborne nickel (0, 100, 200, and 400 μg/L) at 18, 22, and 26 °C for 2 weeks. The exposure concentration of Ni induced a significant Ni accumulation in specific tissues of H. discus hannai depending on water temperature. The order of nickel accumulation in tissues was hepatopancreas > gill ≈ digestive gland > muscle. Regarding antioxidant response indicators, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) in the hepatopancreas and gill tissues of H. discus hannai was significantly increased by the waterborne nickel exposure depending on water temperature. These results suggest that waterborne nickel exposure can induce a considerable nickel accumulation in specific tissues and stimulation of enzymatic antioxidant systems in Pacific abalone, H. discus hannai Ino, 1953 depending on water temperature

    Neural Ganglia Transcriptome and Peptidome Associated with Sexual Maturation in Female Pacific Abalone (<i>Haliotis discus hannai</i>)

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    Genetic information of reproduction and growth is essential for sustainable molluscan fisheries and aquaculture management. However, there is limited knowledge regarding the reproductive activity of the commercially important Pacific abalone Haliotis discus hannai. We performed de novo transcriptome sequencing of the ganglia in sexually immature and mature female Pacific abalone to better understand the sexual maturation process and the underlying molecular mechanisms. Of the ~305 million high-quality clean reads, 76,684 transcripts were de novo-assembled with an average length of 741 bp, 28.54% of which were annotated and classified according to Gene Ontology terms. There were 256 differentially expressed genes between the immature and mature abalone. Tandem mass spectrometry analysis, as compared to the predicted-peptide database of abalone ganglia transcriptome unigenes, identified 42 neuropeptide precursors, including 29 validated by peptidomic analyses. Label-free quantification revealed differential occurrences of 18 neuropeptide families between immature and mature abalone, including achatin, FMRFamide, crustacean cardioactive peptide, and pedal peptide A and B that were significantly more frequent at the mature stage. These results represent the first significant contribution to both maturation-related transcriptomic and peptidomic resources of the Pacific abalone ganglia and provide insight into the roles of various neuropeptides in reproductive regulation in marine gastropods

    Reproductive Cycle and Sexual Group Maturity of <i>Buccinum osagawai</i> (Neogastropoda: Buccinidae)

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    This study was performed to obtain information on the basic reproductive ecology and biological resource management of Buccinum osagawai. Samples were collected from August 2018 to October 2019 with a drum-shaped net at a depth of 150–250 m along the continental shelf in Jumunjin, on the east coast of Korea. The species showed gonochorism and a lack of external sexual dimorphism. The overall sex ratio (F:M) was 1:1.2 (n = 549, F = 250, M = 299); as the size of the individuals increased, the proportion of males tended to decrease. The development pattern of the oocyte was synchronous, in which a dominant group of oocytes was identified within the same ovary. The size of the ripe oocyte was 82.3 (±22.6) × 125.5 (±22.0) μm. The spermatocyte development pattern was group-synchronous, in which multiple stages of germ cell populations were simultaneously identified within the same spermatogenic acinus. The gonad index (GI) for both males and females showed the highest value during June, after which it decreased sharply, and after August it was below 2.0. The main spawning season was from June to July, and the GI and stages of gonadal development did not show a pattern of seasonal changes. The main gonadal active season was from May to July, and both male and female gonadal development and maturation took place over a short period, whereas the recovery period after spawning was longer. At least 60.5% of the group, considering both males and females, showed maturity at 50.1 mm SH or more. Furthermore, the size of 50% group maturity was shown at approximately 50.0 mm SH

    Meta-analysis: selective serotonin reuptake inhibitors and colon cancer

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    Objective To perform meta-analyses using observational studies to assess the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of colorectal cancer.Methods A systematic search of relevant studies published through February 2012 was carried out using the Medline (PubMed), Embase, and Cochrane Library databases. We reviewed the observational studies that were associated with our subject and carried out a meta-analysis.Results Out of 324 screened articles, six observational studies were included in the final analyses. According to this meta-analysis, the use of SSRIs was not associated with an increased risk of colorectal cancer in pooled analyses (adjusted odds ratio 0.89, 95% confidence interval 0.79-1.01). This finding was consistently observed in subgroup analyses of study area, location of colorectal cancer, duration of SSRI use, study quality, adjustment for NSAID use, and the prevalence of overweight.Conclusion Our research shows that the use of SSRIs does not increase the risk of colorectal cancer. Further studies are needed to confirm the association between SSRIs and colorectal cancer. Eur J Gastroenterol Hepatol 24:1153-1157 (C) 2012 Wolters Kluwer Health | Lippincott Williams Wilkins.OAIID:oai:osos.snu.ac.kr:snu2012-01/102/0000052039/6SEQ:6PERF_CD:SNU2012-01EVAL_ITEM_CD:102USER_ID:0000052039ADJUST_YN:YEMP_ID:A077862DEPT_CD:801CITE_RATE:1.757FILENAME:53_Meta-analysis_ selective serotonin reuptake inhibitors and colon cancer.pdfDEPT_NM:의학과EMAIL:[email protected]_YN:YCONFIRM:
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