Dissociation of affective modulation of recollective and perceptual experience following amygdala damage

It has been suggested that similar neural mechanisms may underlie the affective modulation of both recollective and perceptual experience. A case is reported of a patient who has bilateral amygdala damage and marked impairment in the perception of emotion, particularly fear. The patient DR and 10 healthy control subjects (matched for school leaving age, intelligence quotient, and non-emotional memory performance) were shown a series of slides accompanied by an emotionally arousing narrative. One week later DR and the controls were given a surprise memory test for this material. In addition, they completed a verbal memory test using emotionally arousing stimuli. Both DR and the healthy control subjects showed a normative pattern of enhanced memory for emotional material. On the basis of these results and the previously demonstrated impairment of perception of emotion in this patient, it is concluded that different neural mechanisms may underlie affective modulation of recollective and perceptual experience

Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action

Objectives-To investigate the roles of visual and tactile information in a dyspraxic patient with corticobasal degeneration (CBD) who showed dramatic facilitation in miming the use of a tool or object when he was given a tool to manipulate; and to study the nature of the praxic and neuropsychological deficits in CBD. Methods-The subject had clinically diagnosed CBD, and exhibited alien limb behaviour and striking ideomotor dyspraxia. General neuropsychological evaluation focused on constructional and visuospatial abilities, calculation, verbal fluency, episodic and semantic memory, plus spelling and writing because impairments in this domain were presenting complaints. Four experiments assessed the roles of visual and tactile information in the facilitation of motor performance by tools. Experiment I evaluated the patient's performance of six limb transitive actions under six conditions: (1) after he described the relevant tool from memory, (2) after he was shown a Line drawing of the tool, (3) after he was shown a real exemplar of the tool, (4) after he watched the experimenter perform the action, (5) while he was holding the tool, and (6) immediately after he had performed the action with the tool but with the tool removed from his grasp. Experiment 2 evaluated the use of the same six tools when the patient had tactile but no visual information (while he was blindfolded). Experiments 3 and 4 assessed performance of actions appropriate to the same six tools when the patient had either neutral or inappropriate tactile feedback-that is, while he was holding a non-tool object or a different tool. Results-Miming of tool use was not facilitated by visual input; moreover, lack of visual information in the blindfolded condition did not reduce performance. The principal positive finding was a dramatic facilitation of the patient's ability to demonstrate object use when he was holding either the appropriate tool or a neutral object. Tools inappropriate to the requested action produced involuntary performance of the stimulus relevant action. Conclusions-Tactile stimulation was paramount in the facilitation of motor performance in tool use by this patient with CBD. This outcome suggests that tactile information should be included in models which hypothesise modality specific inputs to the action production system. Significant impairments in spelling and letter production that have not previously been reported in CBD have also been documented

Determination of the strange nucleon form factors

The strange contribution to the electric and magnetic form factors of the nucleon is determined at a range of discrete values of $Q^2$ up to $1.4$ GeV$^2$. This is done by combining recent lattice QCD results for the electromagnetic form factors of the octet baryons with experimental determinations of those quantities. The most precise result is a small negative value for the strange magnetic moment: $G_M^s(Q^2=0) = -0.07\pm0.03\,\mu_N$. At larger values of $Q^2$ both the electric and magnetic form factors are consistent with zero to within $2$-sigma

Microwave pulse compression using a helically corrugated waveguide

There has been a drive in recent years to produce ultrahigh power short microwave pulses for a range of applications. These high-power pulses can be produced by microwave pulse compression. Sweep-frequency based microwave pulse compression using smooth bore hollow waveguides is one technique of passive pulse compression, however, at very high powers, this method has some limitation due to its operation close to cutoff. A special helical corrugation of a circular waveguide ensures an eigenwave with strongly frequency dependent group velocity far from cutoff, which makes the helically corrugated waveguide attractive for use as a passive pulse compressor for very high-power amplifiers and oscillators. The results of proof-of-principle experiments and calculations of the wave dispersion using a particle in cell particle-in-cell (PIC) code are presented. In the experiments, a 70-ns 1-kW pulse from a conventional traveling-wave tube (TWT) was compressed in a 2-m-long helical waveguide. The compressed pulse had a peak power of 10.9 kW and duration of 3 ns. In order to find the optimum pulse compression ratio, the waveguide's dispersion characteristics must be well known. The dispersion of the helix was calculated using the PIC code Magic and verified using an experimental technique. Future work detailing plans to produce short ultrahigh power gigawatt (GW) pulses will be discussed

Trait evaluations of faces and voices: Comparing within- and between-person variability

Human faces and voices are rich sources of information that can vary in many different ways. Most of the literature on face/voice perception has focussed on understanding how people look and sound different to each other (between-person variability). However, recent studies highlight the ways in which the same person can look and sound different on different occasions (within-person variability). Across three experiments, we examined how within- and between-person variability relate to one another for social trait impressions by collecting trait ratings attributed to multiple face images and voice recordings of the same people. We find that within-person variability in social trait evaluations is at least as great as between-person variability. Using different stimulus sets across experiments, trait impressions of voices are consistently more variable within people than between people – a pattern that is only evident occasionally when judging faces. Our findings highlight the importance of understanding within-person variability, showing how judgements of the same person can vary widely on different encounters and quantify how this pattern differs for voice and face perception. The work consequently has implications for theoretical models proposing that voices can be considered ‘auditory faces’ and imposes limitations to the ‘kernel of truth’ hypothesis of trait evaluations

Charge Symmetry Violation in the Electromagnetic Form Factors of the Proton

Experimental tests of QCD through its predictions for the strange-quark content of the proton have been drastically restricted by our lack of knowledge of the violation of charge symmetry (CSV). We find unexpectedly tiny CSV in the proton's electromagnetic form factors by performing the first extraction of these quantities based on an analysis of lattice QCD data. The resulting values are an order of magnitude smaller than current bounds on proton strangeness from parity violating electron-proton scattering experiments. This result paves the way for a new generation of experimental measurements of the proton's strange form factors to challenge the predictions of QCD

Achieving consensus on minimum data items (including core outcome domains) for a longitudinal observational cohort study in rheumatoid arthritis

Objectives: To obtain consensus on minimum data items for an observational cohort study in rheumatoid arthritis (RA) in the UK and to make available the process for similar studies and other rheumatic conditions. Methods: Individuals with a diverse range of expertise and backgrounds were invited to participate in a process to propose a minimal core dataset (MCD) for research studies, commissioned by Arthritis Research UK as part of the larger INBANK project. The group included patients and representatives from clinical and academic rheumatology, outcomes science, stratified medicine, health economics, national professional and academic bodies/ committees. A process was devised based on Outcome Measures in Rheumatology Clinical Trials (OMERACT) principles to review aims/objectives, definition of scope, identification of important research questions, and selection of key domains. Results: Following the initial multi-stakeholder meeting, subsequent teleconferences and email communications, consensus was obtained on: 1. Most important and relevant research questions; 2. Agreement on how the OMERACT Core Areas (life impact, pathophysiological manifestations, resource use and death) could form the basis of a MCD; 3. Consensus on 22 items for inclusion into a MCD. Workshops were undertaken for two essential items which required further exploration: work/social participation and co-morbidity. Conclusions: Consensus for proposed minimal data items for long-term observational cohort studies of RA in the UK posed novel challenges and opportunities, and was largely successful. Further work is needed to select instruments for two important items and to achieve compatibility with other UK national initiatives, and more widely across Europe

Knowing no fear

People with brain injuries involving the amygdala are often poor at recognizing facial expressions of fear, but the extent to which this impairment compromises other signals of the emotion of fear has not been clearly established. We investigated N.M., a person with bilateral amygdala damage and a left thalamic lesion, who was impaired at recognizing fear from facial expressions. N.M. showed an equivalent deficit affecting fear recognition from body postures and emotional sounds. His deficit of fear recognition was not linked to evidence of any problem in recognizing anger (a common feature in other reports), but for his everyday experience of emotion N.M. reported reduced anger and fear compared with neurologically normal controls. These findings show a specific deficit compromising the recognition of the emotion of fear from a wide range of social signals, and suggest a possible relationship of this type of impairment with alterations of emotional experience

Occupational asthma: a review.

Occupational asthma is the most common form of occupational lung disease in the developed world at the present time. In this review, the epidemiology, pathogenesis/mechanisms, clinical presentations, management, and prevention of occupational asthma are discussed. The population attributable risk of asthma due to occupational exposures is considerable. Current understanding of the mechanisms by which many agents cause occupational asthma is limited, especially for low-molecular-weight sensitizers and irritants. The diagnosis of occupational asthma is generally established on the basis of a suggestive history of a temporal association between exposure and the onset of symptoms and objective evidence that these symptoms are related to airflow limitation. Early diagnosis, elimination of exposure to the responsible agent, and early use of inhaled steroids may play important roles in the prevention of long-term persistence of asthma. Persistent occupational asthma is often associated with substantial disability and consequent impacts on income and quality of life. Prevention of new cases is the best approach to reducing the burden of asthma attributable to occupational exposures. Future research needs are identified