Different Crystal Chemistries of the 117Cd→117In and 111mCd→111Cd Probes in LiNbO3 and LiTaO3 Studied by Time-Differential Perturbed-Angular-Correlation Technique

金沢大学理学部The temperature dependences of the nuclear-electric-quadrupole frequency vQ of 117In doped in LiTaO3 (TC5938 K) and Li12xInx/3TaO3 with x50.2 (TC5818 K) show that the order-disorder of the Li ions is not the driving mechanism for the ferroelectric instability in LiNbO3 and LiTaO3 systems, and imply that the oxygen order-disorder is the driving mechanism. The significantly different temperature dependences of vQ of 111Cd in these materials compared, to those of 117In, demonstrate that this order-disorder is of dynamic character

Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma

Patients with primary cutaneous melanoma underwent sentinel node (SN) mapping and biopsy at 25 facilities in Japan by the combination of radiocolloid with gamma probe and dye. Technetium-99m (99mTc)-tin colloid, 99mTc-phytate, 2% patent blue violet (PBV) and 0.4% indigo carmine were used as tracers. In some hospitals, 0.5% fluorescent indocyanine green, which allows visualization of the SN with an infrared camera, was concomitantly used and examined. A total of 673 patients were enrolled, and 562 cases were eligible. The detection rates of SN were 95.5% (147/154) with the combination of tin colloid and PBV, 98.9% (368/372) with the combination of phytate and PBV, and 97.2% (35/36) with the combination of tin colloid or phytate and indigo carmine. SN was not detected in 12 cases by the combination method, and the primary tumor was in the head and neck in six of those 12 cases. In eight of 526 cases (1.5%), SN was detected by PBV but not by radiocolloid. There were 13 cases (2.5%) in which SN was detected by radiocolloid but not by PBV. In 18 of 36 cases (50%), SN was detected by radiocolloid but not by indigo carmine. Concomitantly used fluorescent indocyanine green detected SN in all of 67 cases. Interference with transcutaneous oximetry by PVB was observed in some cases, although it caused no clinical trouble. Allergic reactions were not reported with any of the tracers. 99mTc-tin colloid, 99mTc-phytate, PBV and indocyanine green are useful tracers for SN mapping.ArticleJOURNAL OF DERMATOLOGY. 39(4):336-338 (2012)journal articl

Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations

Despite initial dramatic response, epidermal growth factor receptor (EGFR) mutant lung cancer patients always acquire resistance to EGFR-tyrosine kinase inhibitors (TKIs). Gatekeeper T790M mutation in EGFR is the most prevalent genetic alteration underlying acquired resistance to EGFR-TKI, and EGFR mutant lung cancer cells are reported to be addictive to EGFR/Akt signaling even after acquired T790M mutation. Here, we focused on Akt kinase-interacting protein1 (Aki1), a scaffold protein of PI3K (phosphoinositide 3-kinase)/PDK1 (3-phosphoinositide-dependent protein kinase)/Akt that determines receptor signal selectivity for non-mutated EGFR, and assessed its role in EGFR mutant lung cancer with or without gatekeeper T790M mutation. Cell line-based assays showed that Aki1 constitutively associates with mutant EGFR in lung cancer cells with (H1975) or without (PC-9 and HCC827) T790M gatekeeper mutation. Silencing of Aki1 induced apoptosis of EGFR mutant lung cancer cells. Treatment with Aki1 siRNA dramatically inhibited growth of H1975 cells in a xenograft model. Moreover, silencing of Aki1 further potentiated growth inhibitory effect of new generation EGFR-TKIs against H1975 cells in vitro. Aki1 was frequently expressed in tumor cells of EGFR mutant lung cancer patients (53/56 cases), including those with acquired resistance to EGFR-TKI treatment (7/7 cases). Our data suggest that Aki1 may be a critical mediator of survival signaling from mutant EGFR to Akt, and may therefore be an ideal target for EGFR mutant lung cancer patients, especially those with acquired EGFR-TKI resistance due to EGFR T790M gatekeeper mutation.Oncogene advance online publication, 8 October 2012; doi:10.1038/onc.2012.446.In Press → 発行後6か月より全文を公開

コンテンツ保護機能を備えたインターネット生放送システムの実現可能性の研究

コンピュータセキュリティシンポジウム 2012 (Computer Security Symposium 2012, CSS 2012) : 2012年10月30日(火)～11月1日(木) : くにびきメッセ (島根県立産業交流会館)With the popularity of live broadcasting websites such as USTREAM, the maturity of live broadcasting technology, and the improvement of network condition, more and more multimedia service providers are using Internet to do the pay-per-view live broadcasting business instead of traditional TV platform. It becomes an issue which is how to provide an integrated protection scheme to the multimedia contents in the pay-per-view business. For our research, we aim to develop an Internet live broadcasting system with contents protection to solve this issue. We use Home Page cryptosystem to encrypt the contents and use JFD (Joint Fingerprinting and Decryption) method to embed the fingerprint. And it proved feasible according to the evaluation to the system.USTREAMのようなインターネット生放送のWebサイトの人気や配信技術の向上や高速インターネット環境の成熟により, テレビ放送に取って代わるコンテンツ課金型のインターネット生放送の需要が高まってきている. コンテンツ課金型のインターネット生放送を展開する場合は課金したユーザのみがインターネット生放送を視聴できるような仕組みが必要となる. そこで我々は課金したユーザのみがその映像を視聴できるようにするために, 映像に対してJFD(Joint Fingerprinting and Decyption)と呼ばれる手法を用いた暗号化と電子指紋の埋込みを同時に行う仕組みを持ったインターネット生放送を開発した. そして, 開発したインターネット生放送の実現可能性を評価した