A prospective compound screening contest identified broader inhibitors for Sirtuin 1

Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds from a designated compound library containing 2.5 million compounds using in silico methods and scoring. Our aim was to identify target enzyme inhibitors and to benchmark computer-aided drug discovery methods under the same experimental conditions. Collecting compound lists derived from various methods is advantageous for aggregating compounds with structurally diversified properties compared with the use of a single method. The inhibitory action on Sirtuin 1 of approximately half of the proposed compounds was experimentally accessed. Ultimately, seven structurally diverse compounds were identified

Experimental Evaluation of Matching Method Based on Image Impedances for Near Field MIMO

Abstract -In this paper, a novel matching method for near field MIMO is proposed. A concept of image impedance matching is extended to 2×2 MIMO. A proposed matching network was fabricated and tested. The measurement results indicated the proposed matching network offers a high channel capacity since it significantly improves SNR in near field MIMO scheme