Reducing variability among treatment machines using knowledge‐based planning for head and neck, pancreatic, and rectal cancer

PURPOSE: This study aimed to assess dosimetric indices of RapidPlan model-based plans for different energies (6, 8, 10, and 15 MV; 6- and 10-MV flattening filter-free), multileaf collimator (MLC) types (Millennium 120, High Definition 120, dual-layer MLC), and disease sites (head and neck, pancreatic, and rectal cancer) and compare these parameters with those of clinical plans. METHODS: RapidPlan models in the Eclipse version 15.6 were used with the data of 28, 42, and 20 patients with head and neck, pancreatic, and rectal cancer, respectively. RapidPlan models of head and neck, pancreatic, and rectal cancer were created for TrueBeam STx (High Definition 120) with 6 MV, TrueBeam STx with 10-MV flattening filter-free, and Clinac iX (Millennium 120) with 15 MV, respectively. The models were used to create volumetric-modulated arc therapy plans for a 10-patient test dataset using all energy and MLC types at all disease sites. The Holm test was used to compare multiple dosimetric indices in different treatment machines and energy types. RESULTS: The dosimetric indices for planning target volume and organs at risk in RapidPlan model-based plans were comparable to those in the clinical plan. Furthermore, no dose difference was observed among the RapidPlan models. The variability among RapidPlan models was consistent regardless of the treatment machines, MLC types, and energy. CONCLUSIONS: Dosimetric indices of RapidPlan model-based plans appear to be comparable to the ones based on clinical plans regardless of energies, MLC types, and disease sites. The results suggest that the RapidPlan model can generate treatment plans independent of the type of treatment machine

MBE growth of axion insulator candidate EuIn2As2

The synthesis of thin films of magnetic topological materials is necessary to achieve novel quantized Hall effects and electrodynamic responses. EuIn2As2 is a recently predicted topological axion insulator that has an antiferromagnetic ground state and an inverted band structure but that has only been synthesized and studied as a single crystal. We report on the synthesis of c-axis oriented EuIn2As2 films by molecular beam epitaxy on sapphire substrates. By careful tuning of the substrate temperature during growth, we stabilize the Zintl phase of EuIn2As2 expected to be topologically non-trivial. The magnetic properties of these films reproduce those seen in single crystals but their resistivity is enhanced when grown at lower temperatures. We additionally find that the magnetoresistance of EuIn2As2 is negative even up to fields as high as 31T but while it is highly anisotropic at low fields, it becomes nearly isotropic at high magnetic fields above 5T. Overall, the transport characteristics of EuIn2As2 appear similar to those of chalcogenide topological insulators, motivating the development of devices to gate tune the Fermi energy to reveal topological features in quantum transport

増強されたECHアンテナシステムを用いたLHDにおけるECCD適用性の向上

The power injection system for electron cyclotron heating (ECH) and electron cyclotron current drive (ECCD) was modified and upgraded. An outside horizontal port 2-O on the Large Helical Device (LHD) was furnished with two antenna systems for the EC-waves of the frequencies of 77 and 154 GHz, respectively. In addition to them, two new antenna systems for 77 and 154 GHz waves were installed in the 2-O port. Each antenna in the 2-O port has wide range of EC-wave beam direction control so that these are suitable for ECCD which requires toroidally oblique EC-wave beam injection. In the LHD 18th experimental campaign in 2014-2015, an ECCD experiment with second harmonic resonance condition, on-axis magnetic field of 1.375 T for 77 GHz waves, was performed in which some combination patterns of two 77 GHz ECCDs were applied. The discharges of dual co- and dual counter-ECCDs showed remarkable plasma currents of ∼±26 kA in both of the co- and counter-directions, by 6 s pulse duration and injection powers of 366 and 365 kW. The new antenna has nearly the same capability for ECCD with that of the existing antenna. The improvement in the flexibility of the ways of applying plural ECCDs will offer a highly useful tool for investigations on the phenomena concerning with the plasma current such as magnetohydro-dynamics

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Bootstrap method in harmonic oscillator

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Application of Bootstrap to θ\theta-term

Recently, novel numerical computation on quantum mechanics by using a bootstrap method was proposed by Han, Hartnoll, and Kruthoff. We consider whether this method works in systems with a $\theta$-term, where the standard Monte-Carlo computation may fail due to the sign problem. As a starting point, we study quantum mechanics of a charged particle on a circle in which a constant gauge potential is a counterpart of a $\theta$-term. We find that it is hard to determine physical quantities as functions of $\theta$ such as $E(\theta)$, except at $\theta=0$ and $\pi$. On the other hand, the correlations among observables for energy eigenstates are correctly reproduced for any $\theta$. Our results suggest that the bootstrap method may work not perfectly but sufficiently well, even if a $\theta$-term exists in the system.Comment: 16 pages, 5 figures.v3: matches published version in PRD, appendix on the details of the numerical bootstrap was adde

Development of the pulse peak from peak-truncated Gaussian optical pulses in a serial array of high-Q ring resonators

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