Cryptoasset networks: Flows and regular players in Bitcoin and XRP

Cryptoassets flow among players as recorded in the ledger of blockchain for all the transactions, comprising a network of players as nodes and flows as edges. The last decade, on the other hand, has witnessed repeating bubbles and crashes of the price of cryptoassets in exchange markets with fiat currencies and other cryptos. We study the relationship between these two important aspects of dynamics, one in the bubble/crash of price and the other in the daily network of crypto, by investigating Bitcoin and XRP. We focus on “regular players” who frequently appear on a weekly basis during a period of time including bubble/crash, and quantify each player’s role with respect to outgoing and incoming flows by defining flow-weighted frequency. During the most significant period of one-year starting from the winter of 2017, we discovered the structure of three groups of players in the diagram of flow-weighted frequency, which is common to Bitcoin and XRP in spite of the different nature of the two cryptos. By examining the identity and business activity of some regular players in the case of Bitcoin, we can observe different roles of them, namely the players balancing surplus and deficit of cryptoassets (Bal-branch), those accumulating the cryptoassets (In-branch), and those reducing it (Out-branch). Using this information, we found that the regime switching among Bal-, In-, Out-branches was presumably brought about by the regular players who are not necessarily dominant and stable in the case of Bitcoin, while such players are simply absent in the case of XRP. We further discuss how one can understand the temporal transitions among the three branches

Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis

Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels can be used as a biomarker for CRS. Methods: Association between the serum IgG4 levels and clinicopathological factors was analyzed in 336 CRS patients. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of serum IgG4 levels that can be used to predict the post-operative recurrence. Results: Serum IgG4 levels were significantly higher in patients with moderate to severe ECRS versus those with non to mild ECRS. The levels were also significantly higher in asthmatic patients and patients exhibiting recurrence after surgery compared to controls. ROC analysis determined that the best cut-off value for the serum IgG4 level to predict the post-operative recurrence was 95 mg/dL. The corresponding sensitivity and specificity were 39.7% and 80.5%, respectively. When we combined the two cut-off values for the serum IgG4 and periostin, patients with high serum levels of either IgG4 or periostin exhibited a high post-operative recurrence (OR: 3.95) as compared to patients having low serum levels of both IgG4 and periostin. Conclusions: The present results demonstrate that the serum IgG4 level is associated with disease severity and post-operative course in CRS. In particular, the combination of serum IgG4 and periostin could be a novel biomarker that predicts post-operative recurrence

Low Molecular Weight Heparin Prevents Cardiovascular Remodeling Induced by the Long-Term Inhibition of Nitric Oxide Synthase with N-Nitro-L-Arginine Methyl Ester in Rat Hearts

To evaluate the effect of low molecular weight heparin (LMWH) oncardiovascular remodeling induced by long term inhibition of nitric oxide synthase withN-nitro-L-arginine methyl ester (L-NAME), 40 male Sprague-Dawley rats were randomlydivided into four groups: the control group (n=10) that received 0.9% saltsolution; the L-NAME group (n=10) that received 30 mg/kg/day of L-NAME, theLMWH3000 group (n=10) that received 30 mg/kg/day of L-NAME and 4 mg/kg/dayof LMWH (molecular weight (M.W.) of 3000) and the LMWH6000 group (n= 10)that received 30 mg/kg/day of L-NAME and 4 mg/kg/day of LMWH (M.W. 6000).All agents, including saline, were administered intraperitoneally by implantation ofosmotic mini pumps. Systolic blood pressure was measured by the tail-cuff method ontreatment days 1,7, 14, and 28, and histological examination of harvested cardiac tissueand coronary arteries was performed on day 28. Systolic blood pressure was greater inthe L-NAME, LMWH3000 and LMWH6000 groups when compared with the controlgroup. There were no significant differences in activated coagulation time (ACT)when comparing the four groups. Medial smooth muscle cell proliferation and hypertrophyand increases in perivascular and myocardial fibrosis were observed in the L-NAMEgroup compared with the control group. Further, these changes were inhibited by thecoadministration of LMWH3000 or LWMH6000. This study demonstrates that LMWHprevents cardiovascular remodeling induced by L-NAME in rat hearts independent of itsanticoagulant activity. Low molecular weight heparin prevents cardiovascular remodelin

Steady sailing performance of a hybrid-sail assisted bulk carrier

The steady sailing performance of a sail-assisted bulk carrier is investigated utilising towing-tank derived hydrodynamic derivatives and wind tunnel measured aerodynamic properties of the sails and the ship. The aerodynamic characteristics investigated include the ship hull at the fully-loaded draught, the sail–sail interaction effects for two sets of four identical hybrid-sails, and the sail–hull interaction effects for the same two sets of identical sails in the presence of the selected bulk carrier hull-form. This is in addition to lift–drag measurements of single isolated sails of each shape. The form of the two sets of soft sails was rectangular and triangular. This paper is concerned with assessing the benefits of a sail-assisted ship operation, and hence a steady-state rather than complete time-domain integrations of the governing equations are reported. The results of the completed analysis suggest that the benefits of the derived sail generated driving force are greater than the overhead of equipping the ship with a selected system of hybrid-sails. Sail-assisted ships could represent an important contribution to an improving global environment by reducing the demands for a driving force through the propeller

Effect of Orento, a Traditional Japanese Medicine, on IL-6, IL-8 Secretion, Type 1 Collagen Production and Alkaline Phosphatase Secretion in the Human Osteosarcoma Cell Line Saos-2

Background: Orento, a traditional Japanese medicine, is known as Kampo medicine in Japan. We investigated the possible efficacy of Kampo medicine for periodontal disease. In this study, we examined the in vitro effects of orento on the proliferation of the inflammatory cytokines interleukin (IL)-6 and IL-8, the production of type 1 collagen, and the secretion of alkaline phosphatase (ALP) in the human osteosarcoma cell line Saos-2 (Saos-2 cells). Methods: The proliferation of Saos-2 cells was assessed by MTT assay. IL-6 and IL-8 levels, type 1 collagen production and ALP secretion were evaluated using enzyme-linked immunosorbent assay and ALP assays. Saos-2 cells were treated with or without 0.1, 1, 10, 100 and 1000 μg/mL of orento for 24 h. Results: Orento (10 μg/mL) significantly induced the proliferation of Saos-2 cells. At this concentration, orento suppressed IL-6 and IL-8 and enhanced type 1 collagen production and ALP secretion. Conclusions: These results indicate that orento controls the IL-6 and IL-8 secretion and cellular metabolism of osteoblasts, resulting in the secretion of early bone-related biomarkers