光導波機能を有する相分離シンチレータ材料の開発と高分解能X線イメージングへの応用に関する研究

要約のみTohoku University吉川彰課

The ASCA Medium Sensitivity Survey (the GIS Catalog Project): Source Counts and Evidence for Emerging Population of Hard Sources

We present first results from the ASCA Medium Sensitivity Survey (AMSS; or the GIS catalog project). From the serendipitous fields amounting to 106 degE-2, we determined the Log N - Log S relations in the 0.7-7 keV and 2-10 keV bands with the best statistical accuracy obtained so far, over the flux range from 1 x 10E-11 to 5 x 10E-14 and 7 x 10E-14 erg sE-1 cmE-2, respectively. When the sources detected in the 0.7-7 keV band are divided into two subsamples with higher and lower spectral hardness, the former exhibits a significantly steeper slope than the latter at fluxes below ~10E-12 erg sE-1 cmE-2 (0.7-7 keV). The average spectrum of sources becomes continuously harder toward fainter fluxes, from a photon index of 2.1 in the 0.7-10 keV range at the flux of ~10E-11 to 1.6 at ~10E-13 erg sE-1 cmE-2 (0.7-7 keV). This is consistent with the comparison of source counts between the 2-10 keV and the 0.7-2 keV band, and solves the puzzle of their discrepancy reported previously. Our results demonstrate rapid emergence of hard X-ray sources with a decreasing flux from \~10E-12 to ~10E-13 erg sE-1 cmE-2 (2-10 keV).Comment: 10 pages, 3 figures (including 2 color figures). Accepted for publication in ApJ

The hardest X-ray source in the ASCA Large Sky Survey: Discovery of a new type 2 Seyfert

We present results of ASCA deep exposure observations of the hardest X-ray source discovered in the ASCA Large Sky Survey (LSS) project, designated as AX J131501+3141. We extract its accurate X-ray spectrum, taking account of the contamination from a nearby soft source (AX J131502+3142), separated only by 1'. AX J131501+3141 exhibits a large absorption of NH = (6 +4 -2)x 10^22 H/cm^2 with a photon index \Gamma = 1.5 +0.7 -0.6. The 2--10 keV flux was about 5 x 10^-13 erg/s/cm^2 and was time variable by a factor of 30% in 0.5 year. From the highly absorbed X-ray spectrum and the time variability, as well as the results of the optical follow-up observations (Akiyama et al. 1998, astro-ph/9801173), we conclude that AX J131501+3141 is a type 2 Seyfert galaxy. Discovery of such a low flux and highly absorbed X-ray source could have a significant impact on the origin of the cosmic X-ray background.Comment: 16 pages, 6 figures, requires AAS Latex macro v4.0, to appear in The Astrophysical Journal, text and figures also available at http://www-cr.scphys.kyoto-u.ac.jp/member/sakano/work/paper/index-e.htm

Erratum: ASCA Observations of the Absorption-Line Features from the Super-Luminal Jet Source GRS 1915+105

We have discovered errors in the calculation of some of the Einstein coefficients in Table 5 and some plots in Figure 3. Due to the errors, the square-root section of the curves of growth of Fe xxvi Ka and Kb, and Ni xxviii Ka in Figure 3 were a few times underestimated. We correct Table 5 and re-plot Figure 3 together with the unaffected curves. The program to calculate the corrected curves of growth is available at http://www.hp.phys.titech.ac.jp/kotani/cog/index.htmlComment: Erratum with 1 table and 1 figure submitted to ApJ. Original paper include

An Open-labeled, Multicenter Phase II Study of Tamibarotene in Patients with Steroid-refractory Chronic Graft-versus-Host Disease

Chronic graft-versus-host disease (GVHD) is a major cause of late death and morbidity following allogeneic hematopoietic cell transplantation (HSCT). Retinoic acid (tamibarotene) exerts multiple effects on cell differentiation and is clinically used for the treatment of acute promyelocytic leukemia. Tamibarotene down-regulates both Th1 and Th17 differentiation in donor T cells after allogeneic HSCT, resulting in attenuation of experimental chronic GVHD. Based on preclinical data, we have launched a phase II study of tamibarotene in patients with steroid-refractory chronic GVHD. This study will clarify whether tamibarotene can exert beneficial effects in patients with steroid-refractory chronic GVHD

HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function

Clinical cancer genome sequencing detects oncogenic variants that are potential targets for cancer treatment, but it also detects variants of unknown significance. These variants may interact with each other to influence tumor pathophysiology, however, such interactions have not been fully elucidated. Additionally, the effect of target therapy for those variants also unclarified. In this study, we investigated the biological functions of a HER2 mutation (G776S mutation) of unknown pathological significance, which was detected together with APC mutation by cancer genome sequencing of samples from a colorectal cancer (CRC) patient. Transfection of the HER2 G776S mutation alone slightly increased the kinase activity and phosphorylation of HER2 protein, but did not activate HER2 downstream signaling or alter the cell phenotype. On the other hand, the HER2 G776S mutation was shown to have strong oncogenic potential when loss of APC function was accompanied. We revealed that loss of APC function increased Wnt pathway activity but also increased RAS-GTP, which increased ERK phosphorylation triggered by HER2 G776S transfection. In addition, afatinib, a pan-HER tyrosine kinase inhibitor, suppressed tumor growth in xenografts derived from HER2 G776S-transfected CRC cells. These findings suggest that this HER2 mutation in CRC may be a potential therapeutic target

Optical Identification of the ASCA Lynx Deep Survey: An Association of QSOs and a Supercluster at z=1.3?

Results of optical identification of the ASCA Lynx deep survey are presented. Six X-ray sources are detected in the 2-7 keV band using the SIS in a 20'x20' field of view with fluxes larger than ~4x10^{-14} erg s-1 cm-2 in the band. Follow-up optical spectroscopic observations were made, and five out of six sources are identified with AGNs/QSOs at redshifts of 0.5-1.3. We also identify two more additional X-ray sources detected in a soft X-ray band with AGNs/QSOs. It is found that three QSOs identified are located at z~1.3. Two rich clusters and several groups of galaxies are also placed at the same redshift in the surveyed field, and projected separations between the QSOs and the clusters are 3-8 Mpc at the redshift.Comment: 15 pages with 3 figures. Accepted to Ap

Log N - Log S Relations and Spectral Properties of Sources from the ASCA Large Sky Survey --- their Implications for the Origin of the Cosmic X-ray Background (CXB)

We carried out the first wide-area unbiased survey with the ASCA satellite in the 0.7-10 keV band around a north Galactic-pole region covering a continuous area of 7 square degrees (Large Sky Survey; LSS). To make the best use of ASCA capability, we developed a new source-detection method where the complicated detector responses are fully taken into account. Applying this method to the entire LSS data independently in the total (0.7-7 keV), hard (2-10 keV), and soft (0.7-2 keV) band, we detected 107 sources altogether with sensitivity limits of 6 x 10E-14 (0.7-7 keV), 1 x 10E-13 (2-10 keV), and 2 x 10E-14 erg sE-1 cmE-2 (0.7-2 keV), respectively. A complete list of the detected sources is presented. Based on detailed studies by Monte Carlo simulations, we evaluated effects of the source confusion and accurately derived Log N - Log S relation in each survey band. The Log N - Log S relation in the hard band is located on the extrapolation from the GINGA and HEAO1 results with the Euclidean slope of -3/2, while that in the soft band is consistent with the results by ROSAT. At these flux limits, 30 (+/- 3) percent of the CXB in the 0.7-7 keV band and 23 (+/- 3) percent in the 2-10 keV band have been resolved into discrete sources. The average spectrum of faint sources detected in the total band shows a photon index of 1.63 +/- 0.07 in the 0.7-10 keV range, consistent with the comparison of source counts between the hard and the soft energy band. Those detected in the hard band show a photon index of 1.49 +/- 0.10 in the 2-10 keV range. These spectral properties suggest that contribution of sources with hard energy spectra become significant at a flux of 10E-13 erg sE-1 cmE-2 (2-10 keV). The most plausible candidates are type-II AGNs, as indicated by on-going optical identifications.Comment: 28 pages, 11 figures, to appear in ApJ 518, 1999; figure 1 replaced, minor errors in text correcte

The Nature of Ultra-Luminous Compact X-Ray Sources in Nearby Spiral Galaxies

Studies were made of ASCA spectra of seven ultra-luminous compact X-ray sources (ULXs) in nearby spiral galaxies; M33 X-8 (Takano et al. 1994), M81 X-6 (Fabbiano 1988b; Kohmura et al. 1994; Uno 1997), IC 342 Source 1 (Okada et al. 1998), Dwingeloo 1 X-1 (Reynolds et al. 1997), NGC 1313 Source B (Fabbiano & Trinchieri 1987; Petre et al. 1994), and two sources in NGC 4565 (Mizuno et al. 1999). With the 0.5--10 keV luminosities in the range 10^{39-40} ergs/s, they are thought to represent a class of enigmatic X-ray sources often found in spiral galaxies. For some of them, the ASCA data are newly processed, or the published spectra are reanalyzed. For others, the published results are quoted. The ASCA spectra of all these seven sources have been described successfully with so called multi-color disk blackbody (MCD) emission arising from optically-thick standard accretion disks around black holes. Except the case of M33 X-8, the spectra do not exhibit hard tails. For the source luminosities not to exceed the Eddington limits, the black holes are inferred to have rather high masses, up to ~100 solar masses. However, the observed innermost disk temperatures of these objects, Tin = 1.1--1.8 keV, are too high to be compatible with the required high black-hole masses, as long as the standard accretion disks around Schwarzschild black holes are assumed. Similarly high disk temperatures are also observed from two Galactic transients with superluminal motions, GRO 1655-40 and GRS 1915+105. The issue of unusually high disk temperature may be explained by the black hole rotation, which makes the disk get closer to the black hole, and hence hotter.Comment: submitted to ApJ, December 199