Influence on uncertainty of earthquake response analysis results by initial particle arrangements and cohesion parameters in extended distinct element method

Following the occurrence of extremely large earthquakes, such as the Great East Japan Earthquake, the level of design for earthquake ground motion in nuclear power plants has been enhanced. Additionally, the quantitative evaluation of the seismic performance of critical facilities, such as nuclear power plants, and earthquake-induced failure of surrounding slopes are becoming increasingly important as deterministic approaches in regulation. However, evaluation of other aspects besides the design for earthquake ground motion in probabilistic risk assessment (PRA) needs to be conducted voluntarily by the corporation. For the earthquake response analysis, including the seamless transition of the slope from continuum to dis-continuum, the extended distinct element method (EDEM) is an effective approach; however, EDEM is characterised by initial particle arrangement uncertainty. Therefore, we investigated the uncertainty in the EDEM results with respect to failure timing and region. Although essential in the evaluation of impact force in the PRA framework, there are few researches regarding the uncertainty of impact force on the wall of the reactor building after slope failure caused by numerous initial particle arrangements. Furthermore, reducing the computational time is crucial in PRA. Hence, the parameters that do not have an influence on the EDEM results can be omitted, resulting in their dispersion and a reduction in the computational time. This research aims to investigate the impact force uncertainty caused by initial particle arrangements and the influence of cohesion uncertainty. For the former, we conducted 50 numerical simulations for the uncertainty of EDEM results caused by the initial particle arrangements. For the latter, we conducted 50 numerical simulations with two uncertainty factors, namely, cohesion and initial particle arrangement. The simulation results revealed that the largest and second largest loads on the wall occurred in two cases, namely, when there were single particles impacting the wall and when there were group particles impacting the wall. Additionally, the uncertainty caused by cohesion was less than that arrangement when the coefficient of variation was 0.1. Thus, the cohesion uncertainty can be ignored if it is somewhat small

Growth, Yield and Fruit Quality of Tomato as Affected by Root Zone Restriction in Combination with Solar-mediated Fertigation Regime

　Plant growth and fruit development of tomato (Lycopersicon esculentum Mill. cv. House Momotaro) grown in different sized plastic pots (root zone volume, RZV, of 250, 500, 1,000 mL/plant) in combination with high or low rate of drip fertigation (HF and LF) were investigated. In the February-sown experiment, the plants were fertigated with standard to half strength of Ohtsuka-A solution in proportion to solar radiation keeping the ratio of drainage to supplied solution as 10 to 20ｵ, in 500mL- and 250mL-RZV for HF and LF, respectively. Stem and leaf growth decreased with decrease in RZV and the fertigation rate. The decreases were not significant in the distal plant part lower than the 4th inflorescence. The average fruit weight was greater in HF than LF and increased with increase in RZV only for HF. The incidence of blossom-end rot (BER) was more frequent in HF compared to LF and increased with increase in RZV only for LF. Consequently, fruit yield increased with increase in RZV for HF, but it decreased with increase in RZV for LF. Total soluble solid content (TSS) was significantly higher in LF than in HF and increased with decrease in RZV. Qualified fruits, called ‘fruit tomato’ having 8ｵ of TSS or higher, were obtained with 250 to 500mL of RZV in the successive October-sown experiment where the standard solution was supplied throughout. For ‘fruit tomato’ production with a substrate culture system, root zone restriction, in combination with solar-mediated fertigation control, can be a useful and stable stress factor, reducing shoot and fruit growth, but inducing fruit sugar accumulation and reducing BER incidence simultaneously

Time-series photometry of Earth flyby asteroid 2012 DA14

Context. The object 2012 DA14 is a near-Earth asteroid with a size of several tens of meters. It had approached closely the Earth on 15 February, 2013 UT, providing an opportunity for precise measurements of this tiny asteroid. Aims. The solar phase angle of 2012 DA14 had varied widely around its closest approach but was almost constant during the following night. We performed time-series photometric observations on those two nights to determine the rotational properties and phase effect. Methods. The observations were carried out using the 0.55-m telescope at Saitama University, Japan. The R-band images were obtained continuously over a 2 hr period at the closest approach and for about 5 hr on the next night. Results. The lightcurve data from the second night indicates a rotational period of 11.0 +1.8/-0.6 hr and a peak-to-peak amplitude of 1.59 +/- 0.02 mag. The brightness variation before and after the closest approach was separated into two components that are derived from the rotation and phase effect. We found that the phase curve slope of this asteroid is significantly shallower than those of other L-type asteroids. Conclusions. We suggest that 2012 DA14 is coated with a coarse surface that lacks fine regolith particles and/or a high albedo surface.Comment: 4 pages, 4 figures, accepted for publication in Astronomy and Astrophysic

Effects of ezetimibe add-on therapy for high-risk patients with dyslipidemia

<p>Abstract</p> <p>Background</p> <p>Ezetimibe (Zetia^®) is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia. Statin, an inhibitor of cholesterol synthesis, is the first-choice drug to reduce low-density lipoprotein-cholesterol (LDL-C) for patients with hypercholesterolemia, due to its strong effect to lower the circulating LDL-C levels. Because a high dose of statins cause concern about rhabdomyolysis, it is sometimes difficult to achieve the guideline-recommended levels of LDL-C in high-risk patients with hypercholesterolemia treated with statin monotherapy. Ezetimibe has been reported to reduce LDL-C safely with both monotherapy and combination therapy with statins.</p> <p>Results</p> <p>To investigate the effect of ezetimibe as "add-on" therapy to statin on hypercholesterolemia, we examined biomarkers and vascular endothelial function in 14 patients with hypercholesterolemia before and after the 22-week ezetimibe add-on therapy. Ezetimibe add-on therapy reduced LDL-C by 24% compared with baseline (p < 0.005), with 13 patients (93%) reaching their LDL cholesterol goals. Of the Ezetimibe add-on therapy significantly improved not only LDL-C, high-density lipoprotein-cholesterol (HDL-C), and apolipoprotein (apo)B levels, but also reduced levels of triglyceride (TG), the ratio of LDL/HDL-C, the ratio of apoB/apoA-I, and a biomarker for oxidative stress (d-ROMs). Furthermore, ezetimibe add-on therapy improved vascular endothelial function in high-risk patients with hypercholesterolemia.</p> <p>Conclusion</p> <p>In conclusion, ezetimibe as add-on therapy to statin might be a therapeutic good option for high-risk patients with atherosclerosis.</p

Phase angle and extracellular water-to-total body water ratio estimated by bioelectrical impedance analysis are associated with levels of hemoglobin and hematocrit in patients with diabetes

Background: Anemia is one of the common complications of diabetes and is associated with mortality. Phase angle (PhA), ratio of extracellular water to total body water (ECW/TBW) and skeletal muscle mass index (SMI) estimated by bioelectrical impedance analysis (BIA) have been used as prognostic indicators for various chronic diseases and frailty. We aimed to clarify the clinical significance of PhA, ECW/TBW and SMI for anemia in patients with diabetes. Materials and methods: The values of PhA, ECW/TBW and SMI were estimated by a portable BIA device and blood samples were collected in 371 Japanese patients with diabetes. The relationships of PhA, ECW/TBW and SMI with hemoglobin (Hgb) and hematocrit (Hct) were statistically evaluated. Results: In simple linear regression analysis, PhA and SMI were positively correlated with Hgb and Hct levels in total subjects, male subjects and female subjects. In contrast, ECW/TBW was negatively correlated with Hgb and Hct levels regardless of sex. Multivariate regression analysis showed that both PhA and ECW/TBW but not SMI independently contributed to Hgb and Hct levels after adjustment of clinical confounding factors in both males and females. Conclusions: PhA and ECW/TBW but not SMI were associated with levels of Hgb and Hct in patients with diabetes. Therefore, aberrant values of PhA and ECW/TBW suggest a risk of anemia in diabetic patients

Recent Results from LHD Experiment with Emphasis on Relation to Theory from Experimentalist’s View

he Large Helical Device (LHD) has been extending an operational regime of net-current free plasmas towardsthe fusion relevant condition with taking advantage of a net current-free heliotron concept and employing a superconducting coil system. Heating capability has exceeded 10 MW and the central ion and electron temperatureshave reached 7 and 10 keV, respectively. The maximum value of β and pulse length have been extended to 3.2% and 150 s, respectively. Many encouraging physical findings have been obtained. Topics from recent experiments, which should be emphasized from the aspect of theoretical approaches, are reviewed. Those are (1) Prominent features in the inward shifted configuration, i.e., mitigation of an ideal interchange mode in the configuration with magnetic hill, and confinement improvement due to suppression of both anomalous and neoclassical transport, (2) Demonstration ofbifurcation of radial electric field and associated formation of an internal transport barrier, and (3) Dynamics of magnetic islands and clarification of the role of separatrix

COVID-19 vaccine effectiveness against severe COVID-19 requiring oxygen therapy, invasive mechanical ventilation, and death in Japan: A multicenter case-control study (MOTIVATE study).

INTRODUCTION: Since the SARS-CoV-2 Omicron variant became dominant, assessing COVID-19 vaccine effectiveness (VE) against severe disease using hospitalization as an outcome became more challenging due to incidental infections via admission screening and variable admission criteria, resulting in a wide range of estimates. To address this, the World Health Organization (WHO) guidance recommends the use of outcomes that are more specific to severe pneumonia such as oxygen use and mechanical ventilation. METHODS: A case-control study was conducted in 24 hospitals in Japan for the Delta-dominant period (August-November 2021; "Delta") and early Omicron (BA.1/BA.2)-dominant period (January-June 2022; "Omicron"). Detailed chart review/interviews were conducted in January-May 2023. VE was measured using various outcomes including disease requiring oxygen therapy, disease requiring invasive mechanical ventilation (IMV), death, outcome restricting to "true" severe COVID-19 (where oxygen requirement is due to COVID-19 rather than another condition(s)), and progression from oxygen use to IMV or death among COVID-19 patients. RESULTS: The analysis included 2125 individuals with respiratory failure (1608 cases [75.7%]; 99.2% of vaccinees received mRNA vaccines). During Delta, 2 doses provided high protection for up to 6 months (oxygen requirement: 95.2% [95% CI:88.7-98.0%] [restricted to "true" severe COVID-19: 95.5% {89.3-98.1%}]; IMV: 99.6% [97.3-99.9%]; fatal: 98.6% [92.3-99.7%]). During Omicron, 3 doses provided high protection for up to 6 months (oxygen requirement: 85.5% [68.8-93.3%] ["true" severe COVID-19: 88.1% {73.6-94.7%}]; IMV: 97.9% [85.9-99.7%]; fatal: 99.6% [95.2-99.97]). There was a trend towards higher VE for more severe and specific outcomes. CONCLUSION: Multiple outcomes pointed towards high protection of 2 doses during Delta and 3 doses during Omicron. These results demonstrate the importance of using severe and specific outcomes to accurately measure VE against severe COVID-19, as recommended in WHO guidance in settings of intense transmission as seen during Omicron