チイキ ショウガイ ガクシュウ プラットフォーム トシテノ インターネット シミンジュク

eラーニングを活用した生涯学習システムとしてインターネット市民塾が開発された。単なるeラーニングではなく,学びの共同体として,市民誰でもが参加でき,同時に,市民自らが講師となって,経験知や地域資源をネット公開できるフリーマーケット方式で学習を進める。地域色豊かなスクーリング,人と地域を活性化する特性,30-40歳代といった働き盛りの参加が多いことなどから注目が集まり,富山を起点に全国へと広がりつつある。現在,再チャレンジ推進力を持った生涯学習プラットフォームとして拡張・リニューアル作業に取り組んでいる。生涯学習にとどまらず地域再生・活性化に効果するプラットフォームの役割を担いつつある。本稿ではこれらについて報告する。Internet Shiminjuku was developed as a life-long learning system for citizens. It is not just a so-called e-system of life-long learning, but a flea market system where learners can share the knowledge and materials that have been formed and accumulated in the community. The schooling of Internet Shiminjuku is held at the practical situation. Citizens, especially in the age of 30-40 year olds, were activated to join the life-long learning by using the e-system of Internet Shiminjuku. With these findings it was discussed that the Internet Shiminjuku would work as a platform of community revitalization. We are now engaged in renewing it to enhance the human activities to try to find another chance as well as to expand the functions of life-long learning

トクシマ インターネット シミンジュク ノ セツリツ ト ソノゴ ニ ツイテ

インターネット市民塾はICT活用型の生涯学習システムである。単なるeラーニングではなく,市民が自ら講師となって,自ら築きあげた技や巧,地域の知識や資源をネット公開する方式で学習を進める。地域色豊かなスクーリング,人と地域を活性化する特性に注目が集まり,富山を起点に全国へと広がりつつある。徳島では2005年2月,産官学民連携のもと全国6番目のインターネット市民塾を立ち上げ,2006年3月にNPO法人化した。現在,地域活性化,創生力を持った地域プラットフォームへの拡張・リニューアル作業に取り組んでおり,これらについて報告する。Tokushima Internet Shiminjuku has started on February in 2005 to provide the community service as a life-long learning system in Tokushima prefecture. It is not just a so-called e-system of life-long learning, but a flea market system where learners can share the knowledge and materials that have been formed and accumulated in the community. Citizens can join in the Internet Shiminjuku as a lecturer as well as a learner. With these characteristics, Internet Shiminjukuis is expected to become a platform of community revitalization. We are now engaged in renewing it to enhance the function to support human activities to try to find another chance as well as to expand the functions to support life-long learning

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target