56 research outputs found
Aggressive Angiomyxoma of the Scrotum Mimicking Huge Hydrocele: Case Report and Literature Review
Aggressive Angiomyxoma (AAM) is a rare mesenchymal benign myxoid tumor of the pelvis and perineum which occurs almost exclusively in adult females. We are presenting a case of 64 year old male patient with a slowly growing scrotal swelling which has been regarded as hydrocele for 2 years. The patient was referred to scrotal exploration. At surgery a huge mass adjacent to the bulbar urethra was found, not involving the testicles. The morphological picture and the special stains were compatible with aggressive angiomyxoma of the scrotum and peritoneum
Long-Term Urinary Bladder Function Following Unilateral Refluxing Low Loop Cutaneous Ureterostomy
Unanesthetized Rodents Demonstrate Insensitivity of QT Interval and Ventricular Refractory Period to Pacing Cycle Length
Aim: The cardiac electrophysiology of mice and rats has been analyzed extensively, often in the context of pathological manipulations. However, the effects of beating rate on the basic electrical properties of the rodent heart remain unclear. Due to technical challenges, reported electrophysiological studies in rodents are mainly from ex vivo preparations or under deep anesthesia, conditions that might be quite far from the normal physiological state. The aim of the current study was to characterize the ventricular rate-adaptation properties of unanesthetized rats and mice.Methods: An implanted device was chronically implanted in rodents for atrial or ventricular pacing studies. Following recovery from surgery, QT interval was evaluated in rodents exposed to atrial pacing at various frequencies. In addition, the frequency dependence of ventricular refractoriness was tested by conventional ventricular programmed stimulation protocols.Results: Our findings indicate total absence of conventional rate-adaptation properties for both QT interval and ventricular refractoriness. Using monophasic action potential recordings in isolated mice hearts we could confirm the previously reported shortening of the action potential duration at fast pacing rates. However, we found that this mild shortening did not result in similar decrease of ventricular refractory period.Conclusion: Our findings indicate that unanesthetized rodents exhibit flat QT interval and ventricular refractory period rate-dependence. This data argue against empirical use of QT interval correction methods in rodent studies. Our new methodology allowing atrial and ventricular pacing of unanesthetized freely moving rodents may facilitate more appropriate utility of these important animal models in the context of cardiac electrophysiology studies
The scientific payload of the Ultraviolet Transient Astronomy Satellite (ULTRASAT)
The Ultraviolet Transient Astronomy Satellite (ULTRASAT) is a space-borne
near UV telescope with an unprecedented large field of view (200 sq. deg.). The
mission, led by the Weizmann Institute of Science and the Israel Space Agency
in collaboration with DESY (Helmholtz association, Germany) and NASA (USA), is
fully funded and expected to be launched to a geostationary transfer orbit in
Q2/3 of 2025. With a grasp 300 times larger than GALEX, the most sensitive UV
satellite to date, ULTRASAT will revolutionize our understanding of the hot
transient universe, as well as of flaring galactic sources. We describe the
mission payload, the optical design and the choice of materials allowing us to
achieve a point spread function of ~10arcsec across the FoV, and the detector
assembly. We detail the mitigation techniques implemented to suppress
out-of-band flux and reduce stray light, detector properties including measured
quantum efficiency of scout (prototype) detectors, and expected performance
(limiting magnitude) for various objects.Comment: Presented in the SPIE Astronomical Telescopes + Instrumentation 202
Differential modulation of cerebellar climbing fiber and parallel fiber synaptic responses at high pressure
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