30,716 research outputs found
Initial Observations of Sunspot Oscillations Excited by Solar Flare
Observations of a large solar flare of December 13, 2006, using Solar Optical
Telescope (SOT) on Hinode spacecraft revealed high-frequency oscillations
excited by the flare in the sunspot chromosphere. These oscillations are
observed in the region of strong magnetic field of the sunspot umbra, and may
provide a new diagnostic tool for probing the structure of sunspots and
understanding physical processes in solar flares.Comment: 10 pages, 6 figures, ApJL in pres
The role of binaries in the enrichment of the early Galactic halo. I. r-process-enhanced metal-poor stars
The detailed chemical composition of most metal-poor halo stars has been
found to be highly uniform, but a minority of stars exhibit dramatic
enhancements in their abundances of heavy neutron-capture elements and/or of
carbon. The key question for Galactic chemical evolution models is whether
these peculiarities reflect the composition of the natal clouds, or if they are
due to later mass transfer of processed material from a binary companion. If
the former case applies, the observed excess of certain elements was implanted
within selected clouds in the early ISM from a production site at interstellar
distances. Our aim is to determine the frequency and orbital properties of
binaries among these chemically peculiar stars. This information provides the
basis for deciding whether mass transfer from a binary companion is necessary
and sufficient to explain their unusual compositions. This paper discusses our
study of a sample of 17 moderately (r-I) and highly (r-II) r-process-element
enhanced VMP and EMP stars. High-resolution, low signal-to-noise spectra of the
stars were obtained at roughly monthly intervals over 8 years with the FIES
spectrograph at the Nordic Optical Telescope. From these spectra, radial
velocities with an accuracy of ~100 m/s were determined by cross-correlation
against an optimized template. 14 of the programme stars exhibit no significant
RV variation over this period, while 3 are binaries with orbits of typical
eccentricity for their periods, resulting in a normal binary frequency of
~18+-6% for the sample. Our results confirm our preliminary conclusion from
2011, based on partial data, that the chemical peculiarity of the r-I and r-II
stars is not caused by any putative binary companions. Instead, it was
imprinted on the natal molecular clouds of these stars by an external, distant
source. Models of the ISM in early galaxies should account for such mechanisms.Comment: 14 pages, 3 figures, accepted for publication in Astronomy and
Astrophysic
Inhibition of glucocorticoid-induced apoptosis by targeting splice variants of \u3ci\u3eBIM\u3c/i\u3e mRNA with small interfering RNA and short hairpin RNA.
Glucocorticoids (GCs) induce apoptosis in lymphocytes and are effective agents for the treatment of leukemia. The activated glucocorticoid receptor (GR) initiates a transcriptional program leading to caspase activation and cell death, but the critical signaling intermediates in GC-induced apoptosis remain largely undefined. We have observed that GC induction of the three major protein products of the Bcl-2 relative Bim (BimEL, BimS and BimL) correlates with GC sensitivity in a panel of human pre-B acute lymphoblastic leukemia (ALL) cell lines. To test the hypothesis that Bim facilitates GC-induced apoptosis, we reduced BIM mRNA levels and Bim protein levels by RNA interference (RNAi) in highly GC-sensitive pre-B ALL cells. Reducing Bim proteins by either electroporation of synthetic siRNA duplexes or lentiviral-mediated stable expression of shRNA inhibited activation of caspase-3 and increased cell viability following GC exposure. We also observed that the extent of GC resistance correlated with siRNA silencing potency. siRNA duplexes that reduced only BimEL or BimEL and BimL (but not BimS) exhibited less GC resistance than a potent siRNA that silenced all three major isoforms, implying that induction of all three Bim proteins contributes to cell death. Finally, the modulation of GC-induced apoptosis caused by Bim silencing was independent of Bcl-2 expression levels, negating the hypothesis that the ratio of Bim to Bcl-2 regulates apoptosis. These results offer evidence that induction of Bim by GC is a required event for the complete apoptotic response in pre-B ALL cells
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