Effects of C and Al on hydrogen embrittlement mechanism in medium Mn-Ni steels

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Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders

Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, and hypertension. Several molecular drug targets with potential to prevent or treat metabolic disorders have been revealed. Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs to the nuclear receptor superfamily, has many beneficial clinical effects. PPAR directly modulates gene expression by binding to a specific ligand. All PPAR subtypes (α, γ, and σ) are involved in glucose metabolism, lipid metabolism, and energy balance. PPAR agonists play an important role in therapeutic aspects of metabolic disorders. However, undesired effects of the existing PPAR agonists have been reported. A great deal of recent research has focused on the discovery of new PPAR modulators with more beneficial effects and more safety without producing undesired side effects. Herein, we briefly review the roles of PPAR in metabolic disorders, the effects of PPAR modulators in metabolic disorders, and the technologies with which to discover new PPAR modulators

Impacts of Reforestation on Stabilization of Riverine Water Levels in South Korea

We investigate how reforestation contributed to stabilization of riverine water levels in South Korea. For the purpose, we estimate an equation capturing dynamic relationships among rainfall, upstream-area tree stock, and downstream water levels in three river systems of Hongcheon, Mangyeong, and Hyeongsan, using daily observations of precipitation and water levels for the period from 1985 to 2005. Simulation based on estimation results shows that increase in the tree stock in a river basin leads to a significantly suppressed peaking in riverine water levels in response to an abrupt and concentrated rain in the upstream area. For instance, an hour-long concentration of 100mm rain results in 0.7m rise in water level if the volume of growing stock is 1 million m3 , whereas the rise in water level stays below 0.27m with 5 million m3 in the growing-stock volume