13 research outputs found
CHLAMYDIA TRACHOMATIS AND INFERTILITY
Get PDFAlmost one-quarter of 100 asymptomatic men under investigation for fertility has significant titres of lg-А antibodies (> 1:8) specific for Chlamydia trachomatis (CT) in seminal plasma. No clear association was evident between the presence of these antibodies and sperm quality. The female partners of men with consistently high serum or seminal plasma levels of Chlamydia-specific Ig A also exhibited a positive Ig-A reaction in serum without any clinical indications of infection. The study indicated that chronic asymptomatic infections with CT could be responsible for a large number of cases of infertility. It also implied that any men and women under investigation for infertility should be routinely screened with Chlamydial serology regardless of previous history and clinical finding
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Get PDFAcross multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Fatty acid composition of subcutaneous and visceral fat depots in New Zealand White rabbits
No full textThe aim of this study was to identify the differences in the fatty acid composition of subcutaneous and visceral fat depots in healthy New Zealand White rabbits. Twelve clinically healthy rabbits with an average weight of 3.00±0.03 kg were used. The fatty acid composition of interscapular, inguinal, pericardial, perirenal and omental fat depots was determined by gas chromatography. The palmitic (C16:0) and linoleic (C18:2) acids, followed by oleic acid (C18:1) prevailed in all fat depots. The highest percentage of palmitic acid (C16:0) was detected in subcutaneous depots: inguinal (41.05±1.80%) and interscapular (38.30±0.73%), whereas the highest percentage of linoleic acid (C18:2) was found in the visceral depots: perirenal (44.26±0.96%) and pericardial (42.77±1.19%). Among the saturated fatty acids, myristic (C14:0) and stearic acid (C18:0) were established in higher content in subcutaneous depots than in visceral ones. Palmitoleic acid (C16:1) content in the pericardial fat depot was 10.63±2.60%, while in the interscapular, perirenal, omental and inguinal FD it was almost twice lower (Р<0.001). In the omental depot, α-linolenic acid (C18:3) content was significantly higher only vs the interscapular depot (P<0.05). The high content of saturated fatty acids in the subcutaneous depots determined their higher atherogenic and saturation index, unlike visceral ones, where a significantly higher content of unsaturated fatty acids was reported. Differences in fatty acid composition of subcutaneous and visceral fat depots proved the specific metabolism in each of them. On the other hand, this led to differences in the nutritional value of various parts of rabbit carcass
Adipogenic potential of stem cells derived from rabbit subcutaneous and visceral adipose tissue in vitro
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