Synthesis of the chiral intermediate of batzelladines A and B

<p></p> <p>The title compound (<i>S, Z</i>)-methyl 2-[3-(tert-butyldimethylsilyloxy)pyrrolidin-2-ylidene]acetate(<b>6</b>) has been stereoselectively synthesized by the Reformatsky coupling reaction, and the absolute configuration of <b>6</b> was determined by¹H NMRand single-crystal X-ray diffraction.</p